The Role of Stress Regulation on Neural Plasticity in Pain Chronification
Pain, especially chronic pain, is one of the most common clinical symptoms and has been considered as a worldwide healthcare problem. The transition from acute to chronic pain is accompanied by a chain of alterations in physiology, pathology, and psychology. Increasing clinical studies and complemen...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2016-01-01
|
| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2016/6402942 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849695729260429312 |
|---|---|
| author | Xiaoyun Li Li Hu |
| author_facet | Xiaoyun Li Li Hu |
| author_sort | Xiaoyun Li |
| collection | DOAJ |
| description | Pain, especially chronic pain, is one of the most common clinical symptoms and has been considered as a worldwide healthcare problem. The transition from acute to chronic pain is accompanied by a chain of alterations in physiology, pathology, and psychology. Increasing clinical studies and complementary animal models have elucidated effects of stress regulation on the pain chronification via investigating activations of the hypothalamic-pituitary-adrenal (HPA) axis and changes in some crucial brain regions, including the amygdala, prefrontal cortex, and hippocampus. Although individuals suffer from acute pain benefit from such physiological alterations, chronic pain is commonly associated with maladaptive responses, like the HPA dysfunction and abnormal brain plasticity. However, the causal relationship among pain chronification, stress regulation, and brain alterations is rarely discussed. To call for more attention on this issue, we review recent findings obtained from clinical populations and animal models, propose an integrated stress model of pain chronification based on the existing models in perspectives of environmental influences and genetic predispositions, and discuss the significance of investigating the role of stress regulation on brain alteration in pain chronification for various clinical applications. |
| format | Article |
| id | doaj-art-ce313cbcaa3d450292fa80f04428253c |
| institution | DOAJ |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-ce313cbcaa3d450292fa80f04428253c2025-08-20T03:19:41ZengWileyNeural Plasticity2090-59041687-54432016-01-01201610.1155/2016/64029426402942The Role of Stress Regulation on Neural Plasticity in Pain ChronificationXiaoyun Li0Li Hu1Key Laboratory of Cognition and Personality, Ministry of Education and Faculty of Psychology, Southwest University, Chongqing, ChinaKey Laboratory of Cognition and Personality, Ministry of Education and Faculty of Psychology, Southwest University, Chongqing, ChinaPain, especially chronic pain, is one of the most common clinical symptoms and has been considered as a worldwide healthcare problem. The transition from acute to chronic pain is accompanied by a chain of alterations in physiology, pathology, and psychology. Increasing clinical studies and complementary animal models have elucidated effects of stress regulation on the pain chronification via investigating activations of the hypothalamic-pituitary-adrenal (HPA) axis and changes in some crucial brain regions, including the amygdala, prefrontal cortex, and hippocampus. Although individuals suffer from acute pain benefit from such physiological alterations, chronic pain is commonly associated with maladaptive responses, like the HPA dysfunction and abnormal brain plasticity. However, the causal relationship among pain chronification, stress regulation, and brain alterations is rarely discussed. To call for more attention on this issue, we review recent findings obtained from clinical populations and animal models, propose an integrated stress model of pain chronification based on the existing models in perspectives of environmental influences and genetic predispositions, and discuss the significance of investigating the role of stress regulation on brain alteration in pain chronification for various clinical applications.http://dx.doi.org/10.1155/2016/6402942 |
| spellingShingle | Xiaoyun Li Li Hu The Role of Stress Regulation on Neural Plasticity in Pain Chronification Neural Plasticity |
| title | The Role of Stress Regulation on Neural Plasticity in Pain Chronification |
| title_full | The Role of Stress Regulation on Neural Plasticity in Pain Chronification |
| title_fullStr | The Role of Stress Regulation on Neural Plasticity in Pain Chronification |
| title_full_unstemmed | The Role of Stress Regulation on Neural Plasticity in Pain Chronification |
| title_short | The Role of Stress Regulation on Neural Plasticity in Pain Chronification |
| title_sort | role of stress regulation on neural plasticity in pain chronification |
| url | http://dx.doi.org/10.1155/2016/6402942 |
| work_keys_str_mv | AT xiaoyunli theroleofstressregulationonneuralplasticityinpainchronification AT lihu theroleofstressregulationonneuralplasticityinpainchronification AT xiaoyunli roleofstressregulationonneuralplasticityinpainchronification AT lihu roleofstressregulationonneuralplasticityinpainchronification |