Exosomal transfer of pro-pyroptotic miR-216a-5p exacerbates anthracycline cardiotoxicity through breast cancer-heart pathological crosstalk

Exosomal transfer of pro-pyroptotic miR-216a-5p exacerbates anthracycline cardiotoxicity through breast cancer-heart pathological crosstalk

Abstract Doxorubicin (DOX) is the most effective chemotherapeutic for breast cancer, but it is usually associated with severe cardiotoxicity. Further investigation to alleviate its side effects is essential. The present study investigated the mechanism of the cross-organ communication between tumors...

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Main Authors: Yan Ma, Yongjun Wang, Renzheng Chen, Yabin Wang, Yan Fang, Cheng Qin, Tianhu Wang, Xiaoying Shen, Tingwen Zhou, Lei Tian, Ting Sun, Li Fan, Xiaoning Wang, Dong Han, Feng Cao
Format: Article
Language:English
Published: Nature Publishing Group 2025-05-01
Series:Signal Transduction and Targeted Therapy
Online Access:https://doi.org/10.1038/s41392-025-02245-4
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