Insulin-like growth factors in cat placenta
Placental development involves maternal-fetal signalling events, and it is an under-researched topic in feline reproduction. Few studies of endotheliochorial placentas deal with insulin-like growth factors (IGFs), which are among the principal developmental regulators. While placental expression of...
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| Format: | Article |
| Language: | English |
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Universidad Nacional de La Plata
2025-02-01
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| Series: | Analecta Veterinaria |
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| Online Access: | https://revistas.unlp.edu.ar/analecta/article/view/17100 |
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| author | Rocío Hernández Gimena Gomez Castro Fernanda Mariel Rodriguez Luciano Casas Enrique Portiansky |
| author_facet | Rocío Hernández Gimena Gomez Castro Fernanda Mariel Rodriguez Luciano Casas Enrique Portiansky |
| author_sort | Rocío Hernández |
| collection | DOAJ |
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Placental development involves maternal-fetal signalling events, and it is an under-researched topic in feline reproduction. Few studies of endotheliochorial placentas deal with insulin-like growth factors (IGFs), which are among the principal developmental regulators. While placental expression of IGFs and type 1 IGF receptor (IGF1R) has already been reported in bitches, data regarding the IGF system in queens are limited to uterine tissues. This study aimed to detect IGF1, IGF2, and IGF1R in fetal and maternal placental structures. Samples from twenty-three placentas were classified into one of two groups depending on gestational age (G1: ≤43 d.p.c; G2: ≥44 d.p.c) and processed by indirect immunohistochemistry. Labelling with all the antibodies was stronger in the endometrial glands of earlier placentas than in later ones. Maternal endothelium was moderate to strongly labelled, with a decreasing intensity in the endometrium, while the opposite occurred in the labyrinth. Cytotrophoblast cells were more strongly labelled than the syncytiotrophoblast. IGF1 and IGF1R-positive cells were more abundant in decidual cells of later placentas. These results support that the IGF system plays a central role during gestation and development in cats. As far as we know, this is the first report recording immunohistochemical IGFs/IGF1R detection in fetal regions of the feline placenta.
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| format | Article |
| id | doaj-art-ce1dc8adce5d400a955cf8bcefefe1b3 |
| institution | DOAJ |
| issn | 0365-5148 1514-2590 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Universidad Nacional de La Plata |
| record_format | Article |
| series | Analecta Veterinaria |
| spelling | doaj-art-ce1dc8adce5d400a955cf8bcefefe1b32025-08-20T02:48:42ZengUniversidad Nacional de La PlataAnalecta Veterinaria0365-51481514-25902025-02-014410.24215/15142590e090Insulin-like growth factors in cat placentaRocío Hernández0Gimena Gomez Castro1Fernanda Mariel Rodriguez2Luciano Casas3Enrique Portiansky4Universidad Nacional de La Plata, ArgentinaUniversidad de Buenos Aires, Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), ArgentinaUniversidad Nacional del Litoral, ArgentinaUniversidad de Buenos Aires, ArgentinaUniversidad Nacional de La Plata, Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Argentina Placental development involves maternal-fetal signalling events, and it is an under-researched topic in feline reproduction. Few studies of endotheliochorial placentas deal with insulin-like growth factors (IGFs), which are among the principal developmental regulators. While placental expression of IGFs and type 1 IGF receptor (IGF1R) has already been reported in bitches, data regarding the IGF system in queens are limited to uterine tissues. This study aimed to detect IGF1, IGF2, and IGF1R in fetal and maternal placental structures. Samples from twenty-three placentas were classified into one of two groups depending on gestational age (G1: ≤43 d.p.c; G2: ≥44 d.p.c) and processed by indirect immunohistochemistry. Labelling with all the antibodies was stronger in the endometrial glands of earlier placentas than in later ones. Maternal endothelium was moderate to strongly labelled, with a decreasing intensity in the endometrium, while the opposite occurred in the labyrinth. Cytotrophoblast cells were more strongly labelled than the syncytiotrophoblast. IGF1 and IGF1R-positive cells were more abundant in decidual cells of later placentas. These results support that the IGF system plays a central role during gestation and development in cats. As far as we know, this is the first report recording immunohistochemical IGFs/IGF1R detection in fetal regions of the feline placenta. https://revistas.unlp.edu.ar/analecta/article/view/17100catplacentainsulin-like growth factorstrophoblastic cellsimmunihistochemestry |
| spellingShingle | Rocío Hernández Gimena Gomez Castro Fernanda Mariel Rodriguez Luciano Casas Enrique Portiansky Insulin-like growth factors in cat placenta Analecta Veterinaria cat placenta insulin-like growth factors trophoblastic cells immunihistochemestry |
| title | Insulin-like growth factors in cat placenta |
| title_full | Insulin-like growth factors in cat placenta |
| title_fullStr | Insulin-like growth factors in cat placenta |
| title_full_unstemmed | Insulin-like growth factors in cat placenta |
| title_short | Insulin-like growth factors in cat placenta |
| title_sort | insulin like growth factors in cat placenta |
| topic | cat placenta insulin-like growth factors trophoblastic cells immunihistochemestry |
| url | https://revistas.unlp.edu.ar/analecta/article/view/17100 |
| work_keys_str_mv | AT rociohernandez insulinlikegrowthfactorsincatplacenta AT gimenagomezcastro insulinlikegrowthfactorsincatplacenta AT fernandamarielrodriguez insulinlikegrowthfactorsincatplacenta AT lucianocasas insulinlikegrowthfactorsincatplacenta AT enriqueportiansky insulinlikegrowthfactorsincatplacenta |