The Association between Serum Bilirubin Level and Electrochemical Skin Conductance in Chinese Patients with Type 2 Diabetes
Bilirubin is an antioxidant and plays a protective role against cardiovascular and microvascular disease. The aim of this study is to explore the possible protective effect of bilirubin on small nerve function. A total of 265 Chinese patients with type 2 diabetes mellitus (T2DM) were enrolled in the...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2018/6253170 |
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| author | Fei Mao Xiaoming Zhu Bin Lu Yiming Li |
| author_facet | Fei Mao Xiaoming Zhu Bin Lu Yiming Li |
| author_sort | Fei Mao |
| collection | DOAJ |
| description | Bilirubin is an antioxidant and plays a protective role against cardiovascular and microvascular disease. The aim of this study is to explore the possible protective effect of bilirubin on small nerve function. A total of 265 Chinese patients with type 2 diabetes mellitus (T2DM) were enrolled in the study. Both SUDOSCAN and other traditional diabetic neuropathy examinations including neuropathy symptom score (NSS), the neuropathy disability score (NDS) and Michigan Neuropathy Screening Instrument (MNSI) scores were performed in all patients with T2DM. Blood bilirubin levels were tested in the study. Spearman correlation analysis and multivariate regression analysis were performed to determine the relation between bilirubin level and hands and feet ESC values. Spearman correlation analysis demonstrated a correlation between total bilirubin and ESC levels including hands (r=0.165, P<0.05) and feet (r=0.122, P<0.05) as well as between UCBil and ESC levels including both hands (r=0.172, P<0.05) and feet (r=0.175, P<0.05). Multivariate regression linear analyses showed both total bilirubin and UCBil level were independently associated with hands and feet ESC levels. All these results suggested a positive association between bilirubin level and ESC level, indicating a possible protective role of bilirubin in peripheral small nerve dysfunction of type 2 diabetes mellitus. |
| format | Article |
| id | doaj-art-ce168f94a3ac4ef0af260557f9d24918 |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-ce168f94a3ac4ef0af260557f9d249182025-02-03T01:07:24ZengWileyInternational Journal of Endocrinology1687-83371687-83452018-01-01201810.1155/2018/62531706253170The Association between Serum Bilirubin Level and Electrochemical Skin Conductance in Chinese Patients with Type 2 DiabetesFei Mao0Xiaoming Zhu1Bin Lu2Yiming Li3Department of Endocrinology and Metabolism, Huashan Hospital, Fudan University, Shanghai, ChinaDepartment of Endocrinology and Metabolism, Huashan Hospital, Fudan University, Shanghai, ChinaDepartment of Endocrinology and Metabolism, Huashan Hospital, Fudan University, Shanghai, ChinaDepartment of Endocrinology and Metabolism, Huashan Hospital, Fudan University, Shanghai, ChinaBilirubin is an antioxidant and plays a protective role against cardiovascular and microvascular disease. The aim of this study is to explore the possible protective effect of bilirubin on small nerve function. A total of 265 Chinese patients with type 2 diabetes mellitus (T2DM) were enrolled in the study. Both SUDOSCAN and other traditional diabetic neuropathy examinations including neuropathy symptom score (NSS), the neuropathy disability score (NDS) and Michigan Neuropathy Screening Instrument (MNSI) scores were performed in all patients with T2DM. Blood bilirubin levels were tested in the study. Spearman correlation analysis and multivariate regression analysis were performed to determine the relation between bilirubin level and hands and feet ESC values. Spearman correlation analysis demonstrated a correlation between total bilirubin and ESC levels including hands (r=0.165, P<0.05) and feet (r=0.122, P<0.05) as well as between UCBil and ESC levels including both hands (r=0.172, P<0.05) and feet (r=0.175, P<0.05). Multivariate regression linear analyses showed both total bilirubin and UCBil level were independently associated with hands and feet ESC levels. All these results suggested a positive association between bilirubin level and ESC level, indicating a possible protective role of bilirubin in peripheral small nerve dysfunction of type 2 diabetes mellitus.http://dx.doi.org/10.1155/2018/6253170 |
| spellingShingle | Fei Mao Xiaoming Zhu Bin Lu Yiming Li The Association between Serum Bilirubin Level and Electrochemical Skin Conductance in Chinese Patients with Type 2 Diabetes International Journal of Endocrinology |
| title | The Association between Serum Bilirubin Level and Electrochemical Skin Conductance in Chinese Patients with Type 2 Diabetes |
| title_full | The Association between Serum Bilirubin Level and Electrochemical Skin Conductance in Chinese Patients with Type 2 Diabetes |
| title_fullStr | The Association between Serum Bilirubin Level and Electrochemical Skin Conductance in Chinese Patients with Type 2 Diabetes |
| title_full_unstemmed | The Association between Serum Bilirubin Level and Electrochemical Skin Conductance in Chinese Patients with Type 2 Diabetes |
| title_short | The Association between Serum Bilirubin Level and Electrochemical Skin Conductance in Chinese Patients with Type 2 Diabetes |
| title_sort | association between serum bilirubin level and electrochemical skin conductance in chinese patients with type 2 diabetes |
| url | http://dx.doi.org/10.1155/2018/6253170 |
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