Epidemiology of neonatal disorders attributable to low birthweight-global burden of disease research, 1990–2021
BackgroundTo evaluate global, regional, and national trends in the burden of neonatal diseases attributable to LBW, as well as associated health inequalities, from 1990 to 2021.MethodsUsing data from the Global Burden of Disease Study (GBD2021), we analyzed deaths and DALYs due to LBW-attributable n...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-01-01
|
| Series: | Frontiers in Pediatrics |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fped.2024.1461134/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832576369004904448 |
|---|---|
| author | Qi Zhang Lan Luo Lai-lai Yan Lai-lai Yan Jing Guo Hui-jun Wu Zi-wei Zhang Yu-hua Zhu Rui Qiao Rui Qiao |
| author_facet | Qi Zhang Lan Luo Lai-lai Yan Lai-lai Yan Jing Guo Hui-jun Wu Zi-wei Zhang Yu-hua Zhu Rui Qiao Rui Qiao |
| author_sort | Qi Zhang |
| collection | DOAJ |
| description | BackgroundTo evaluate global, regional, and national trends in the burden of neonatal diseases attributable to LBW, as well as associated health inequalities, from 1990 to 2021.MethodsUsing data from the Global Burden of Disease Study (GBD2021), we analyzed deaths and DALYs due to LBW-attributable neonatal diseases. Data were stratified by gender, geographic region, epidemiological characteristics, and SDI levels. Trends and influencing factors were investigated through Joinpoint regression, health inequality analysis, and frontier modeling.ResultsIn 2021, the global age-standardized mortality rate (ASMR) and age-standardized disability-adjusted life year (DALY) rate (ASDR) for neonatal diseases associated with low birth weight (LBW) were 22.76 [95% uncertainty interval (UI): 19.63–26.40] and 2,227.54 (95% UI: 1,939.96–2,563.52) per 100,000, respectively. Over the past 32 years, these rates have consistently declined, with average annual percentage changes (AAPCs) of −1.40 [95% confidence interval (CI): −1.48 to −1.33] for ASMR and −1.27 (95% CI: −1.34 to −1.21) for ASDR. Notably, absolute health inequality related to the Socio-demographic Index (SDI) has decreased, as indicated by a reduction in DALY disparities between the most and least developed countries from −4,216.49 (95% CI: −4,558.27 to −3,874.71) in 1990 to −2,635.35 (95% CI: −2,868.40 to −2,402.30) in 2021. However, relative health inequality has worsened, with the relative disease burden in low-SDI countries increasing from −33.46% (95% CI: −36.29% to −30.63%) to −40.20% (95% CI: −44.02% to −36.39%). The burden of neonatal diseases remains disproportionately concentrated in low-SDI regions. Frontier analyses highlight opportunities for improvement across development levels. Some low-SDI countries have achieved minimal theoretical disease burdens, whereas certain high-SDI countries lag in reducing their neonatal disease burdens.ConclusionOver the past 32 years, the global burden of neonatal diseases attributable to LBW has significantly decreased, but inequality in disease burden has intensified. Addressing this disparity requires sustained international and governmental efforts to improve the accessibility, equality, and quality of healthcare for pregnant women and newborns. |
| format | Article |
| id | doaj-art-ce03b47fc9c14c75b4e360aae2f3724a |
| institution | Kabale University |
| issn | 2296-2360 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pediatrics |
| spelling | doaj-art-ce03b47fc9c14c75b4e360aae2f3724a2025-01-31T06:40:04ZengFrontiers Media S.A.Frontiers in Pediatrics2296-23602025-01-011210.3389/fped.2024.14611341461134Epidemiology of neonatal disorders attributable to low birthweight-global burden of disease research, 1990–2021Qi Zhang0Lan Luo1Lai-lai Yan2Lai-lai Yan3Jing Guo4Hui-jun Wu5Zi-wei Zhang6Yu-hua Zhu7Rui Qiao8Rui Qiao9Department of Public Health, Baotou Medical College, Baotou, ChinaDepartment of Public Health, Baotou Medical College, Baotou, ChinaDepartment of Laboratorial Science and Technology, School of Public Health, Peking University, Beijing, ChinaKey Laboratory of Epidemiology of Major Diseases, Peking University, Ministry of Education, Beijing, ChinaDepartment of Gynecology, Kundulun District Hospital, Baotou, ChinaDepartment of Gynecology and Obstetrics, Sinopharm Northern Hospital, Baotou, ChinaDepartment of Gynecology and Obstetrics, Sinopharm Northern Hospital, Baotou, ChinaDepartment of Public Health, Baotou Medical College, Baotou, ChinaDepartment of Public Health, Baotou Medical College, Baotou, ChinaDepartment of Public Health, International College, Krirk University, Bangkok, ThailandBackgroundTo evaluate global, regional, and national trends in the burden of neonatal diseases attributable to LBW, as well as associated health inequalities, from 1990 to 2021.MethodsUsing data from the Global Burden of Disease Study (GBD2021), we analyzed deaths and DALYs due to LBW-attributable neonatal diseases. Data were stratified by gender, geographic region, epidemiological characteristics, and SDI levels. Trends and influencing factors were investigated through Joinpoint regression, health inequality analysis, and frontier modeling.ResultsIn 2021, the global age-standardized mortality rate (ASMR) and age-standardized disability-adjusted life year (DALY) rate (ASDR) for neonatal diseases associated with low birth weight (LBW) were 22.76 [95% uncertainty interval (UI): 19.63–26.40] and 2,227.54 (95% UI: 1,939.96–2,563.52) per 100,000, respectively. Over the past 32 years, these rates have consistently declined, with average annual percentage changes (AAPCs) of −1.40 [95% confidence interval (CI): −1.48 to −1.33] for ASMR and −1.27 (95% CI: −1.34 to −1.21) for ASDR. Notably, absolute health inequality related to the Socio-demographic Index (SDI) has decreased, as indicated by a reduction in DALY disparities between the most and least developed countries from −4,216.49 (95% CI: −4,558.27 to −3,874.71) in 1990 to −2,635.35 (95% CI: −2,868.40 to −2,402.30) in 2021. However, relative health inequality has worsened, with the relative disease burden in low-SDI countries increasing from −33.46% (95% CI: −36.29% to −30.63%) to −40.20% (95% CI: −44.02% to −36.39%). The burden of neonatal diseases remains disproportionately concentrated in low-SDI regions. Frontier analyses highlight opportunities for improvement across development levels. Some low-SDI countries have achieved minimal theoretical disease burdens, whereas certain high-SDI countries lag in reducing their neonatal disease burdens.ConclusionOver the past 32 years, the global burden of neonatal diseases attributable to LBW has significantly decreased, but inequality in disease burden has intensified. Addressing this disparity requires sustained international and governmental efforts to improve the accessibility, equality, and quality of healthcare for pregnant women and newborns.https://www.frontiersin.org/articles/10.3389/fped.2024.1461134/fullglobal healthepidemiologylow birthweightneonatal disease burdenhealth inequality |
| spellingShingle | Qi Zhang Lan Luo Lai-lai Yan Lai-lai Yan Jing Guo Hui-jun Wu Zi-wei Zhang Yu-hua Zhu Rui Qiao Rui Qiao Epidemiology of neonatal disorders attributable to low birthweight-global burden of disease research, 1990–2021 Frontiers in Pediatrics global health epidemiology low birthweight neonatal disease burden health inequality |
| title | Epidemiology of neonatal disorders attributable to low birthweight-global burden of disease research, 1990–2021 |
| title_full | Epidemiology of neonatal disorders attributable to low birthweight-global burden of disease research, 1990–2021 |
| title_fullStr | Epidemiology of neonatal disorders attributable to low birthweight-global burden of disease research, 1990–2021 |
| title_full_unstemmed | Epidemiology of neonatal disorders attributable to low birthweight-global burden of disease research, 1990–2021 |
| title_short | Epidemiology of neonatal disorders attributable to low birthweight-global burden of disease research, 1990–2021 |
| title_sort | epidemiology of neonatal disorders attributable to low birthweight global burden of disease research 1990 2021 |
| topic | global health epidemiology low birthweight neonatal disease burden health inequality |
| url | https://www.frontiersin.org/articles/10.3389/fped.2024.1461134/full |
| work_keys_str_mv | AT qizhang epidemiologyofneonataldisordersattributabletolowbirthweightglobalburdenofdiseaseresearch19902021 AT lanluo epidemiologyofneonataldisordersattributabletolowbirthweightglobalburdenofdiseaseresearch19902021 AT lailaiyan epidemiologyofneonataldisordersattributabletolowbirthweightglobalburdenofdiseaseresearch19902021 AT lailaiyan epidemiologyofneonataldisordersattributabletolowbirthweightglobalburdenofdiseaseresearch19902021 AT jingguo epidemiologyofneonataldisordersattributabletolowbirthweightglobalburdenofdiseaseresearch19902021 AT huijunwu epidemiologyofneonataldisordersattributabletolowbirthweightglobalburdenofdiseaseresearch19902021 AT ziweizhang epidemiologyofneonataldisordersattributabletolowbirthweightglobalburdenofdiseaseresearch19902021 AT yuhuazhu epidemiologyofneonataldisordersattributabletolowbirthweightglobalburdenofdiseaseresearch19902021 AT ruiqiao epidemiologyofneonataldisordersattributabletolowbirthweightglobalburdenofdiseaseresearch19902021 AT ruiqiao epidemiologyofneonataldisordersattributabletolowbirthweightglobalburdenofdiseaseresearch19902021 |