Effect of physical activity on structural asymmetry of mouse hippocampus
The relevance of studies of adult neurogenesis is evident in connection with the potential use of these new neurons to replace neurons lost in the process of life. Despite considerable efforts, little is known about the fnal fate of these cells, the functional signifcance of their connections and the...
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| Format: | Article |
| Language: | English |
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Siberian Branch of the Russian Academy of Sciences, Federal Research Center Institute of Cytology and Genetics, The Vavilov Society of Geneticists and Breeders
2019-01-01
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| Series: | Вавиловский журнал генетики и селекции |
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| Online Access: | https://vavilov.elpub.ru/jour/article/view/1813 |
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| author | T. A. Zapara A. V. Romashchenko A. L. Proskura A. S. Ratushnyak |
| author_facet | T. A. Zapara A. V. Romashchenko A. L. Proskura A. S. Ratushnyak |
| author_sort | T. A. Zapara |
| collection | DOAJ |
| description | The relevance of studies of adult neurogenesis is evident in connection with the potential use of these new neurons to replace neurons lost in the process of life. Despite considerable efforts, little is known about the fnal fate of these cells, the functional signifcance of their connections and the regulation of their development. It is known that physical activity signifcantly increases the number of fssile progenitors, the precursors of new neurons in the dentate gyrus of the hippocampus. The existing immunohistochemical methods for labeling new neurons do not allow tracing the temporal dynamics of changes in the volume of brain structures in the same animal, induced by external impacts, such as voluntary exercise. This makes it an urgent task to develop and improve methods for longterm control of changes that occur in the adult hippocampus due to the induction of neurogenesis. The main purpose of this work was to noninvasively track, by using magnetic resonance imaging (MRI), the temporal dynamics of changes in the volume of the hippocampus in the same animals that had voluntary physical activity. It was found that voluntary exercise did not change the total volume of the mouse hippocampus. However, the difference in the volume ratio between the right and left parts of the hippocampus was signifcantly lower compared with the control group. The reconstruction and analysis of proteinprotein interactions that ensure the survival of a large number of new neurons and their integration into existing neural networks in the hippocampus have been carried out. The proposed approach allows the noninvasive registration of changes in the ratio of the volumes of these paired brain structures. |
| format | Article |
| id | doaj-art-cdfcb3d76aa54cb7ab49d38fcbbadcc4 |
| institution | Kabale University |
| issn | 2500-3259 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Siberian Branch of the Russian Academy of Sciences, Federal Research Center Institute of Cytology and Genetics, The Vavilov Society of Geneticists and Breeders |
| record_format | Article |
| series | Вавиловский журнал генетики и селекции |
| spelling | doaj-art-cdfcb3d76aa54cb7ab49d38fcbbadcc42025-02-01T09:58:07ZengSiberian Branch of the Russian Academy of Sciences, Federal Research Center Institute of Cytology and Genetics, The Vavilov Society of Geneticists and BreedersВавиловский журнал генетики и селекции2500-32592019-01-012281084108910.18699/VJ18.454861Effect of physical activity on structural asymmetry of mouse hippocampusT. A. Zapara0A. V. Romashchenko1A. L. Proskura2A. S. Ratushnyak3The Institute of Computational Technologies, SB RASThe Institute of Computational Technologies, SB RAS; Institute of Cytology and Genetics, SB RASThe Institute of Computational Technologies, SB RASThe Institute of Computational Technologies, SB RASThe relevance of studies of adult neurogenesis is evident in connection with the potential use of these new neurons to replace neurons lost in the process of life. Despite considerable efforts, little is known about the fnal fate of these cells, the functional signifcance of their connections and the regulation of their development. It is known that physical activity signifcantly increases the number of fssile progenitors, the precursors of new neurons in the dentate gyrus of the hippocampus. The existing immunohistochemical methods for labeling new neurons do not allow tracing the temporal dynamics of changes in the volume of brain structures in the same animal, induced by external impacts, such as voluntary exercise. This makes it an urgent task to develop and improve methods for longterm control of changes that occur in the adult hippocampus due to the induction of neurogenesis. The main purpose of this work was to noninvasively track, by using magnetic resonance imaging (MRI), the temporal dynamics of changes in the volume of the hippocampus in the same animals that had voluntary physical activity. It was found that voluntary exercise did not change the total volume of the mouse hippocampus. However, the difference in the volume ratio between the right and left parts of the hippocampus was signifcantly lower compared with the control group. The reconstruction and analysis of proteinprotein interactions that ensure the survival of a large number of new neurons and their integration into existing neural networks in the hippocampus have been carried out. The proposed approach allows the noninvasive registration of changes in the ratio of the volumes of these paired brain structures.https://vavilov.elpub.ru/jour/article/view/1813magnetic resonance imagingadult neurogenesisstructural asymmetry of the brain |
| spellingShingle | T. A. Zapara A. V. Romashchenko A. L. Proskura A. S. Ratushnyak Effect of physical activity on structural asymmetry of mouse hippocampus Вавиловский журнал генетики и селекции magnetic resonance imaging adult neurogenesis structural asymmetry of the brain |
| title | Effect of physical activity on structural asymmetry of mouse hippocampus |
| title_full | Effect of physical activity on structural asymmetry of mouse hippocampus |
| title_fullStr | Effect of physical activity on structural asymmetry of mouse hippocampus |
| title_full_unstemmed | Effect of physical activity on structural asymmetry of mouse hippocampus |
| title_short | Effect of physical activity on structural asymmetry of mouse hippocampus |
| title_sort | effect of physical activity on structural asymmetry of mouse hippocampus |
| topic | magnetic resonance imaging adult neurogenesis structural asymmetry of the brain |
| url | https://vavilov.elpub.ru/jour/article/view/1813 |
| work_keys_str_mv | AT tazapara effectofphysicalactivityonstructuralasymmetryofmousehippocampus AT avromashchenko effectofphysicalactivityonstructuralasymmetryofmousehippocampus AT alproskura effectofphysicalactivityonstructuralasymmetryofmousehippocampus AT asratushnyak effectofphysicalactivityonstructuralasymmetryofmousehippocampus |