Effect of older age and/or ACL injury on the dose–response relationship between ambulatory load magnitude and immediate load-induced change in serum cartilage oligomeric matrix protein
Purpose: This study aimed to assess the influence of older vs. younger age and previous anterior cruciate ligament (ACL) injury on resting serum cartilage oligomeric matrix protein (sCOMP(tpre)) concentration, on immediate load-induced sCOMP kinetics after a 30-min treadmill walking stress (∆_sCOMP(...
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Elsevier
2025-12-01
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| Series: | Journal of Sport and Health Science |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2095254624001509 |
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| author | Simon Herger Corina Nüesch Anna-Maria Liphardt Christian Egloff Annegret Mündermann |
| author_facet | Simon Herger Corina Nüesch Anna-Maria Liphardt Christian Egloff Annegret Mündermann |
| author_sort | Simon Herger |
| collection | DOAJ |
| description | Purpose: This study aimed to assess the influence of older vs. younger age and previous anterior cruciate ligament (ACL) injury on resting serum cartilage oligomeric matrix protein (sCOMP(tpre)) concentration, on immediate load-induced sCOMP kinetics after a 30-min treadmill walking stress (∆_sCOMP(tpost)), and on the dose–response relationship between ambulatory load magnitude and ∆_sCOMP(tpost). Methods: A total of 85 participants were recruited in 4 groups (20–30 years: 24 healthy, 23 ACL-injured; 40–60 years: 23 healthy, 15 ACL-injured). Blood samples were collected immediately before and after a walking stress at 80%, 100%, or 120% bodyweight (BW) on 3 test days and analyzed for sCOMP concentration. Linear models were used to estimate the effect of age, knee status (unilateral ACL injury, 2–10 years prior), and sex on sCOMP(tpre), ∆_sCOMP(tpost), and the dose–response between ambulatory load magnitude and ∆_sCOMP(tpost). Results: We found that sCOMP(tpre) was 21% higher in older than younger participants (p < 0.001) but did not differ between ACL-injured and healthy participants (p = 0.632). Also, ∆_sCOMP(tpost) was 19% lower in older than younger participants (p = 0.030) and increased with body mass index (p < 0.001), sCOMP(tpre) (p = 0.008), and with 120%BW (p < 0.001), independent of age, ACL injury, or sex. Conclusion: Age but not prior ACL injury influences resting sCOMP and load-induced sCOMP. The dose–response relationship between ambulatory load magnitude and load-induced sCOMP changes is not affected by age, ACL injury, or sex. A better understanding of systemic sCOMP and the role of its mechanoresponse for the understanding of osteoarthritis pathophysiology and monitoring intervention efficacy may require knowledge of individual cartilage composition and tissue-level loading parameters. |
| format | Article |
| id | doaj-art-cdf6db22a4134598b398ceaba060c1e9 |
| institution | Kabale University |
| issn | 2095-2546 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Sport and Health Science |
| spelling | doaj-art-cdf6db22a4134598b398ceaba060c1e92025-01-19T06:24:55ZengElsevierJournal of Sport and Health Science2095-25462025-12-0114100993Effect of older age and/or ACL injury on the dose–response relationship between ambulatory load magnitude and immediate load-induced change in serum cartilage oligomeric matrix proteinSimon Herger0Corina Nüesch1Anna-Maria Liphardt2Christian Egloff3Annegret Mündermann4Department of Orthopedics and Traumatology, University Hospital Basel, Basel 4031, Switzerland; Department of Spine Surgery, University Hospital Basel, Basel 4031, Switzerland; Department of Biomedical Engineering, University of Basel, Basel 4031, Switzerland; Department of Clinical Research, University of Basel, Basel 4031, Switzerland; Corresponding author.Department of Orthopedics and Traumatology, University Hospital Basel, Basel 4031, Switzerland; Department of Spine Surgery, University Hospital Basel, Basel 4031, Switzerland; Department of Biomedical Engineering, University of Basel, Basel 4031, Switzerland; Department of Clinical Research, University of Basel, Basel 4031, SwitzerlandDepartment of Internal Medicine 3 – Rheumatology and Immunology, Friedrich-Alexander-Universität Erlangen-Nürnberg, Universitätsklinikum Erlangen, Erlangen 91054, Germany; Deutsches Zentrum Immuntherapie, Friedrich-Alexander-Universität Erlangen-Nürnberg, Universitätsklinikum Erlangen, Erlangen 91054, GermanyDepartment of Orthopedics and Traumatology, University Hospital Basel, Basel 4031, SwitzerlandDepartment of Orthopedics and Traumatology, University Hospital Basel, Basel 4031, Switzerland; Department of Spine Surgery, University Hospital Basel, Basel 4031, Switzerland; Department of Biomedical Engineering, University of Basel, Basel 4031, Switzerland; Department of Clinical Research, University of Basel, Basel 4031, SwitzerlandPurpose: This study aimed to assess the influence of older vs. younger age and previous anterior cruciate ligament (ACL) injury on resting serum cartilage oligomeric matrix protein (sCOMP(tpre)) concentration, on immediate load-induced sCOMP kinetics after a 30-min treadmill walking stress (∆_sCOMP(tpost)), and on the dose–response relationship between ambulatory load magnitude and ∆_sCOMP(tpost). Methods: A total of 85 participants were recruited in 4 groups (20–30 years: 24 healthy, 23 ACL-injured; 40–60 years: 23 healthy, 15 ACL-injured). Blood samples were collected immediately before and after a walking stress at 80%, 100%, or 120% bodyweight (BW) on 3 test days and analyzed for sCOMP concentration. Linear models were used to estimate the effect of age, knee status (unilateral ACL injury, 2–10 years prior), and sex on sCOMP(tpre), ∆_sCOMP(tpost), and the dose–response between ambulatory load magnitude and ∆_sCOMP(tpost). Results: We found that sCOMP(tpre) was 21% higher in older than younger participants (p < 0.001) but did not differ between ACL-injured and healthy participants (p = 0.632). Also, ∆_sCOMP(tpost) was 19% lower in older than younger participants (p = 0.030) and increased with body mass index (p < 0.001), sCOMP(tpre) (p = 0.008), and with 120%BW (p < 0.001), independent of age, ACL injury, or sex. Conclusion: Age but not prior ACL injury influences resting sCOMP and load-induced sCOMP. The dose–response relationship between ambulatory load magnitude and load-induced sCOMP changes is not affected by age, ACL injury, or sex. A better understanding of systemic sCOMP and the role of its mechanoresponse for the understanding of osteoarthritis pathophysiology and monitoring intervention efficacy may require knowledge of individual cartilage composition and tissue-level loading parameters.http://www.sciencedirect.com/science/article/pii/S2095254624001509AgingCartilage blood biomarkerKnee injuryMechanosensitivityRisk for OA |
| spellingShingle | Simon Herger Corina Nüesch Anna-Maria Liphardt Christian Egloff Annegret Mündermann Effect of older age and/or ACL injury on the dose–response relationship between ambulatory load magnitude and immediate load-induced change in serum cartilage oligomeric matrix protein Journal of Sport and Health Science Aging Cartilage blood biomarker Knee injury Mechanosensitivity Risk for OA |
| title | Effect of older age and/or ACL injury on the dose–response relationship between ambulatory load magnitude and immediate load-induced change in serum cartilage oligomeric matrix protein |
| title_full | Effect of older age and/or ACL injury on the dose–response relationship between ambulatory load magnitude and immediate load-induced change in serum cartilage oligomeric matrix protein |
| title_fullStr | Effect of older age and/or ACL injury on the dose–response relationship between ambulatory load magnitude and immediate load-induced change in serum cartilage oligomeric matrix protein |
| title_full_unstemmed | Effect of older age and/or ACL injury on the dose–response relationship between ambulatory load magnitude and immediate load-induced change in serum cartilage oligomeric matrix protein |
| title_short | Effect of older age and/or ACL injury on the dose–response relationship between ambulatory load magnitude and immediate load-induced change in serum cartilage oligomeric matrix protein |
| title_sort | effect of older age and or acl injury on the dose response relationship between ambulatory load magnitude and immediate load induced change in serum cartilage oligomeric matrix protein |
| topic | Aging Cartilage blood biomarker Knee injury Mechanosensitivity Risk for OA |
| url | http://www.sciencedirect.com/science/article/pii/S2095254624001509 |
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