Clinical Report of Probable Catastrophic Antiphospholipid Syndrome in Pregnancy
Background. Catastrophic APS (CAPS) is a rare but life-threatening form of APS defined as multiorgan thrombosis affecting a minimum of three organs with confirmation by histopathology of small vessel occlusions in at least one organ or tissue. The development of CAPS in pregnancy poses many diagnost...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2018-01-01
|
| Series: | Case Reports in Obstetrics and Gynecology |
| Online Access: | http://dx.doi.org/10.1155/2018/4176456 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832548152936235008 |
|---|---|
| author | Eryk Hakman Sasha Mikhael |
| author_facet | Eryk Hakman Sasha Mikhael |
| author_sort | Eryk Hakman |
| collection | DOAJ |
| description | Background. Catastrophic APS (CAPS) is a rare but life-threatening form of APS defined as multiorgan thrombosis affecting a minimum of three organs with confirmation by histopathology of small vessel occlusions in at least one organ or tissue. The development of CAPS in pregnancy poses many diagnostic challenges as a result of its broad range of clinical presentations and its overlap with other obstetric complications and microangiopathic diseases. Because of the high associated mortality rate, prompt recognition and treatment are paramount. Case. A twenty-five-year-old G3P0111 with a history of multiple thromboembolisms presented at 21 weeks and 3 days of gestation with complaints of right upper quadrant pain, visual disturbances, headache, and syncopal episodes. Laboratory evaluation demonstrated microangiopathic disease with hemolysis (confirmed on peripheral smear), elevated liver enzymes, and abnormal 24-hour urine protein with vital signs within the normal range. Presence of significantly elevated antiphospholipid antibodies was noted, facilitating the diagnosis of probable CAPS. Proper workup was achieved based on clinical suspicion, allowing immediate and appropriate management. Conclusion. CAPS is a life-threatening condition rarely seen in pregnancy making early recognition difficult. A low threshold to initiate urgent and aggressive treatment should be maintained to minimize the risk of adverse outcomes. |
| format | Article |
| id | doaj-art-cdf6ca921d73446bafc06263766f8e49 |
| institution | Kabale University |
| issn | 2090-6684 2090-6692 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Obstetrics and Gynecology |
| spelling | doaj-art-cdf6ca921d73446bafc06263766f8e492025-02-03T06:42:01ZengWileyCase Reports in Obstetrics and Gynecology2090-66842090-66922018-01-01201810.1155/2018/41764564176456Clinical Report of Probable Catastrophic Antiphospholipid Syndrome in PregnancyEryk Hakman0Sasha Mikhael1American University of the Caribbean, Coral Gables, FL, USADepartment of Obstetrics and Gynecology, Michigan State University College of Human Medicine, Providence Hospital, Southfield, MI, USABackground. Catastrophic APS (CAPS) is a rare but life-threatening form of APS defined as multiorgan thrombosis affecting a minimum of three organs with confirmation by histopathology of small vessel occlusions in at least one organ or tissue. The development of CAPS in pregnancy poses many diagnostic challenges as a result of its broad range of clinical presentations and its overlap with other obstetric complications and microangiopathic diseases. Because of the high associated mortality rate, prompt recognition and treatment are paramount. Case. A twenty-five-year-old G3P0111 with a history of multiple thromboembolisms presented at 21 weeks and 3 days of gestation with complaints of right upper quadrant pain, visual disturbances, headache, and syncopal episodes. Laboratory evaluation demonstrated microangiopathic disease with hemolysis (confirmed on peripheral smear), elevated liver enzymes, and abnormal 24-hour urine protein with vital signs within the normal range. Presence of significantly elevated antiphospholipid antibodies was noted, facilitating the diagnosis of probable CAPS. Proper workup was achieved based on clinical suspicion, allowing immediate and appropriate management. Conclusion. CAPS is a life-threatening condition rarely seen in pregnancy making early recognition difficult. A low threshold to initiate urgent and aggressive treatment should be maintained to minimize the risk of adverse outcomes.http://dx.doi.org/10.1155/2018/4176456 |
| spellingShingle | Eryk Hakman Sasha Mikhael Clinical Report of Probable Catastrophic Antiphospholipid Syndrome in Pregnancy Case Reports in Obstetrics and Gynecology |
| title | Clinical Report of Probable Catastrophic Antiphospholipid Syndrome in Pregnancy |
| title_full | Clinical Report of Probable Catastrophic Antiphospholipid Syndrome in Pregnancy |
| title_fullStr | Clinical Report of Probable Catastrophic Antiphospholipid Syndrome in Pregnancy |
| title_full_unstemmed | Clinical Report of Probable Catastrophic Antiphospholipid Syndrome in Pregnancy |
| title_short | Clinical Report of Probable Catastrophic Antiphospholipid Syndrome in Pregnancy |
| title_sort | clinical report of probable catastrophic antiphospholipid syndrome in pregnancy |
| url | http://dx.doi.org/10.1155/2018/4176456 |
| work_keys_str_mv | AT erykhakman clinicalreportofprobablecatastrophicantiphospholipidsyndromeinpregnancy AT sashamikhael clinicalreportofprobablecatastrophicantiphospholipidsyndromeinpregnancy |