Biparatopic antibodies: therapeutic applications and prospects
Biparatopic antibodies (bpAbs) bind distinct, non-overlapping epitopes on an antigen. This unique binding mode enables new mechanisms of action beyond monospecific and bispecific antibodies (bsAbs) that can make bpAbs effective therapeutics for various indications, including oncology and infectious...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2024-12-01
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| Series: | mAbs |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/19420862.2024.2310890 |
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| author | David L. Niquille Kyle M. Fitzgerald Nimish Gera |
| author_facet | David L. Niquille Kyle M. Fitzgerald Nimish Gera |
| author_sort | David L. Niquille |
| collection | DOAJ |
| description | Biparatopic antibodies (bpAbs) bind distinct, non-overlapping epitopes on an antigen. This unique binding mode enables new mechanisms of action beyond monospecific and bispecific antibodies (bsAbs) that can make bpAbs effective therapeutics for various indications, including oncology and infectious diseases. Biparatopic binding can lead to superior affinity and specificity, promote antagonism, lock target conformation, and result in higher-order target clustering. Such antibody-target complexes can elicit strong agonism, increase immune effector function, or result in rapid target downregulation and lysosomal trafficking. These are not only attractive properties for therapeutic antibodies but are increasingly being explored for other modalities such as antibody-drug conjugates, T-cell engagers and chimeric antigen receptors. Recent advances in bpAb engineering have enabled the construction of ever more sophisticated formats that are starting to show promise in the clinic. |
| format | Article |
| id | doaj-art-cded80158e66447d85469dfb9b9c7945 |
| institution | Kabale University |
| issn | 1942-0862 1942-0870 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | mAbs |
| spelling | doaj-art-cded80158e66447d85469dfb9b9c79452025-01-31T04:19:38ZengTaylor & Francis GroupmAbs1942-08621942-08702024-12-0116110.1080/19420862.2024.2310890Biparatopic antibodies: therapeutic applications and prospectsDavid L. Niquille0Kyle M. Fitzgerald1Nimish Gera2Biologics, Mythic Therapeutics, Waltham, MA, USABiologics, Mythic Therapeutics, Waltham, MA, USABiologics, Mythic Therapeutics, Waltham, MA, USABiparatopic antibodies (bpAbs) bind distinct, non-overlapping epitopes on an antigen. This unique binding mode enables new mechanisms of action beyond monospecific and bispecific antibodies (bsAbs) that can make bpAbs effective therapeutics for various indications, including oncology and infectious diseases. Biparatopic binding can lead to superior affinity and specificity, promote antagonism, lock target conformation, and result in higher-order target clustering. Such antibody-target complexes can elicit strong agonism, increase immune effector function, or result in rapid target downregulation and lysosomal trafficking. These are not only attractive properties for therapeutic antibodies but are increasingly being explored for other modalities such as antibody-drug conjugates, T-cell engagers and chimeric antigen receptors. Recent advances in bpAb engineering have enabled the construction of ever more sophisticated formats that are starting to show promise in the clinic.https://www.tandfonline.com/doi/10.1080/19420862.2024.2310890Antibody engineeringantibody-drug conjugatesbiparatopic antibodiesbispecific antibodieschimeric antigen receptorsinfectious disease |
| spellingShingle | David L. Niquille Kyle M. Fitzgerald Nimish Gera Biparatopic antibodies: therapeutic applications and prospects mAbs Antibody engineering antibody-drug conjugates biparatopic antibodies bispecific antibodies chimeric antigen receptors infectious disease |
| title | Biparatopic antibodies: therapeutic applications and prospects |
| title_full | Biparatopic antibodies: therapeutic applications and prospects |
| title_fullStr | Biparatopic antibodies: therapeutic applications and prospects |
| title_full_unstemmed | Biparatopic antibodies: therapeutic applications and prospects |
| title_short | Biparatopic antibodies: therapeutic applications and prospects |
| title_sort | biparatopic antibodies therapeutic applications and prospects |
| topic | Antibody engineering antibody-drug conjugates biparatopic antibodies bispecific antibodies chimeric antigen receptors infectious disease |
| url | https://www.tandfonline.com/doi/10.1080/19420862.2024.2310890 |
| work_keys_str_mv | AT davidlniquille biparatopicantibodiestherapeuticapplicationsandprospects AT kylemfitzgerald biparatopicantibodiestherapeuticapplicationsandprospects AT nimishgera biparatopicantibodiestherapeuticapplicationsandprospects |