Intranasal delivery of blackberry-loaded Chitosan nanoparticles for antipsychotic potential in Ketamine-induced schizophrenia in rats

Intranasal delivery of blackberry-loaded Chitosan nanoparticles for antipsychotic potential in Ketamine-induced schizophrenia in rats

Abstract Schizophrenia is a neuropsychiatric disorder with limited treatment options that have unwanted side effects. Clozapine, an atypical antipsychotic, has been used for resistant schizophrenia. This study investigated the effect of anthocyanin-rich extract from Rubus fruticosus (RFE) loaded int...

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Bibliographic Details
Main Authors: Mina Y. George, Nermeen Farag, Esther T. Menze, Reham S. Elezaby, Nayera A. Salem, Shereen K. Elrahmany, Nahed Adel, Rana M. ElKhatib, Menna Galal, Hams Assem, Radwa Elkhouly, Mariam Alkess Wesa, Noha Hesham, Nouran Hossam, Iriny M. Ayoub
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Scientific Reports
Subjects:
Rubus fruticosus
Anthocyanins
UPLC-ESI-MS/MS
Chitosan
Schizophrenia
Clozapine
Online Access:https://doi.org/10.1038/s41598-025-00918-2
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