Human immunodeficiency virus-1 induces host genomic R-loops and preferentially integrates its genome near the R-loop regions

Human immunodeficiency virus-1 induces host genomic R-loops and preferentially integrates its genome near the R-loop regions

Although HIV-1 integration sites favor active transcription units in the human genome, high-resolution analysis of individual HIV-1 integration sites has shown that the virus can integrate into a variety of host genomic locations, including non-genic regions. The invisible infection by HIV-1 integra...

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Bibliographic Details
Main Authors: Kiwon Park, Dohoon Lee, Jiseok Jeong, Sungwon Lee, Sun Kim, Kwangseog Ahn
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2024-12-01
Series:eLife
Subjects:
HIV-1
integration
R-loop
Online Access:https://elifesciences.org/articles/97348
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