Phadiatop Infant in the Diagnosis of Atopy in Children with Allergy-Like Symptoms
Background and Objective. Allergy-like symptoms such as wheezing and eczema are common in young children and an early diagnosis is important to initiate correct management. The objective of this study was to evaluate the diagnostic performance of Phadiatop Infant, an in vitro test for determination...
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| Format: | Article |
| Language: | English |
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Wiley
2009-01-01
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| Series: | International Journal of Pediatrics |
| Online Access: | http://dx.doi.org/10.1155/2009/460737 |
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| author | Ragnhild Halvorsen Åsa Jenner Else Marie Hagelin Magnus P. Borres |
| author_facet | Ragnhild Halvorsen Åsa Jenner Else Marie Hagelin Magnus P. Borres |
| author_sort | Ragnhild Halvorsen |
| collection | DOAJ |
| description | Background and Objective. Allergy-like symptoms such as wheezing and eczema are common in young children and an early diagnosis is important to initiate correct management. The objective of this study was to evaluate the diagnostic performance of Phadiatop Infant, an in vitro test for determination of early sensitisation to food and inhalant allergens. Patients and Methods. The study was conducted, retrospectively, using frozen sera from 122 children (median age 2.7 years) admitted to the hospital with suspected allergic symptoms. The doctor's diagnosis atopic/nonatopic was based on routinely used procedures such as clinical evaluation, SPT, total and allergen-specific IgE antibodies. The performance of Phadiatop Infant was evaluated in a blinded manner against this diagnosis. Results. Eighty-four of the 86 children classified as atopic showed a positive Phadiatop Infant test. Thirty-six were classified as nonatopic, 32 of who had a negative test. With a prevalence of atopy of 70% in this population, this gives a sensitivity of 98%, a specificity of 89%, and a positive and negative predictive value of 95% and 94%, respectively. Conclusion. The results from the present study suggest that Phadiatop Infant could be recommended as a complement to the clinical information in the differential diagnosis on IgE-mediated disease in young children with allergy-like symptoms. |
| format | Article |
| id | doaj-art-cdddf41502f449edbf64e846fe35151b |
| institution | Kabale University |
| issn | 1687-9740 1687-9759 |
| language | English |
| publishDate | 2009-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Pediatrics |
| spelling | doaj-art-cdddf41502f449edbf64e846fe35151b2025-02-03T01:25:28ZengWileyInternational Journal of Pediatrics1687-97401687-97592009-01-01200910.1155/2009/460737460737Phadiatop Infant in the Diagnosis of Atopy in Children with Allergy-Like SymptomsRagnhild Halvorsen0Åsa Jenner1Else Marie Hagelin2Magnus P. Borres3Voksentoppen Center for Asthma, Allergy and Chronic Lung Diseases, University Hospital, 0791 Oslo, NorwayPhadia AB, 75137 Uppsala, SwedenVoksentoppen Center for Asthma, Allergy and Chronic Lung Diseases, University Hospital, 0791 Oslo, NorwayPhadia AB, 75137 Uppsala, SwedenBackground and Objective. Allergy-like symptoms such as wheezing and eczema are common in young children and an early diagnosis is important to initiate correct management. The objective of this study was to evaluate the diagnostic performance of Phadiatop Infant, an in vitro test for determination of early sensitisation to food and inhalant allergens. Patients and Methods. The study was conducted, retrospectively, using frozen sera from 122 children (median age 2.7 years) admitted to the hospital with suspected allergic symptoms. The doctor's diagnosis atopic/nonatopic was based on routinely used procedures such as clinical evaluation, SPT, total and allergen-specific IgE antibodies. The performance of Phadiatop Infant was evaluated in a blinded manner against this diagnosis. Results. Eighty-four of the 86 children classified as atopic showed a positive Phadiatop Infant test. Thirty-six were classified as nonatopic, 32 of who had a negative test. With a prevalence of atopy of 70% in this population, this gives a sensitivity of 98%, a specificity of 89%, and a positive and negative predictive value of 95% and 94%, respectively. Conclusion. The results from the present study suggest that Phadiatop Infant could be recommended as a complement to the clinical information in the differential diagnosis on IgE-mediated disease in young children with allergy-like symptoms.http://dx.doi.org/10.1155/2009/460737 |
| spellingShingle | Ragnhild Halvorsen Åsa Jenner Else Marie Hagelin Magnus P. Borres Phadiatop Infant in the Diagnosis of Atopy in Children with Allergy-Like Symptoms International Journal of Pediatrics |
| title | Phadiatop Infant in the Diagnosis of Atopy in Children with Allergy-Like Symptoms |
| title_full | Phadiatop Infant in the Diagnosis of Atopy in Children with Allergy-Like Symptoms |
| title_fullStr | Phadiatop Infant in the Diagnosis of Atopy in Children with Allergy-Like Symptoms |
| title_full_unstemmed | Phadiatop Infant in the Diagnosis of Atopy in Children with Allergy-Like Symptoms |
| title_short | Phadiatop Infant in the Diagnosis of Atopy in Children with Allergy-Like Symptoms |
| title_sort | phadiatop infant in the diagnosis of atopy in children with allergy like symptoms |
| url | http://dx.doi.org/10.1155/2009/460737 |
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