Identification of RNF114 as ADPr-Ub reader through non-hydrolysable ubiquitinated ADP-ribose

Identification of RNF114 as ADPr-Ub reader through non-hydrolysable ubiquitinated ADP-ribose

Abstract Crosstalk between the post-translational modification processes of ubiquitination and ADP-ribosylation occurs in DNA-damage- and immune-responses, in addition the physical linkage of ADP-ribose and ubiquitin is found during bacterial infection. Here, we study the ubiquitination of ADP-ribos...

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Main Authors: Max S. Kloet, Chatrin Chatrin, Rishov Mukhopadhyay, Bianca D. M. van Tol, Rebecca Smith, Sarah A. Rotman, Rayman T. N. Tjokrodirijo, Kang Zhu, Andrii Gorelik, Lucy Maginn, Paul R. Elliott, Peter A. van Veelen, Dragana Ahel, Ivan Ahel, Gerbrand J. van der Heden van Noort
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-61111-7
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