Altered phenotypic and metabolic characteristics of FOXP3+CD3+CD56+ natural killer T (NKT)-like cells in human malignant pleural effusion

Altered phenotypic and metabolic characteristics of FOXP3+CD3+CD56+ natural killer T (NKT)-like cells in human malignant pleural effusion

Malignant pleural effusion (MPE) is a functional ‘cold’ tumor microenvironment in which the antitumor activity of CD8+ T cells and natural killer T (NKT)-like cells is suppressed and the function of regulatory T (Treg) cells is enhanced. Using flow cytometry and immunofluorescence staining, we detec...

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Bibliographic Details
Main Authors: Zi-Hao Wang, Pei Zhang, Wen-Bei Peng, Lin-Lin Ye, Xuan Xiang, Xiao-Shan Wei, Yi-Ran Niu, Si-Yu Zhang, Qian-Qian Xue, Hao-Lei Wang, Qiong Zhou
Format: Article
Language:English
Published: Taylor & Francis Group 2023-12-01
Series:OncoImmunology
Subjects:
Malignant pleural effusion
NKT-like cell
FOXP3
MCT1
lactylation
scRNA-seq
Online Access:https://www.tandfonline.com/doi/10.1080/2162402X.2022.2160558
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