Glycyrrhetinic Acid-Poly(ethylene glycol)-glycyrrhetinic Acid Tri-Block Conjugates Based Self-Assembled Micelles for Hepatic Targeted Delivery of Poorly Water Soluble Drug
The triblock 18β-glycyrrhetinic acid-poly(ethylene glycol)-18β-glycyrrhetinic acid conjugates (GA-PEG-GA) based self-assembled micelles were synthesized and characterized by FTIR, NMR, transmission electron microscopy, and particle size analysis. The GA-PEG-GA conjugates having the critical micelle...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2013-01-01
|
| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1155/2013/913654 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832556981623193600 |
|---|---|
| author | Fengbo Wu Ting Xu Chi Liu Can Chen Xiangrong Song Yu Zheng Gu He |
| author_facet | Fengbo Wu Ting Xu Chi Liu Can Chen Xiangrong Song Yu Zheng Gu He |
| author_sort | Fengbo Wu |
| collection | DOAJ |
| description | The triblock 18β-glycyrrhetinic acid-poly(ethylene glycol)-18β-glycyrrhetinic acid conjugates (GA-PEG-GA) based self-assembled micelles were synthesized and characterized by FTIR, NMR, transmission electron microscopy, and particle size analysis. The GA-PEG-GA conjugates having the critical micelle concentration of M were used to form nanosized micelles, with mean diameters of 159.21 ± 2.2 nm, and then paclitaxel (PTX) was incorporated into GA-PEG-GA micelles by self-assembly method. The physicochemical properties of the PTX loaded GA-PEG-GA micelles were evaluated including in vitro cellular uptake, cytotoxicity, drug release profile, and in vivo tissue distribution. The results demonstrate that the GA-PEG-GA micelles had low cytotoxicity and good ability of selectively delivering drug to hepatic cells in vitro and in vivo by the targeting moiety glycyrrhetinic acid. In conclusion, the GA-PEG-GA conjugates have potential medical applications for targeted delivery of poor soluble drug delivery. |
| format | Article |
| id | doaj-art-cdcae5c469df43509c5f1cf1df280ec5 |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-cdcae5c469df43509c5f1cf1df280ec52025-02-03T05:43:54ZengWileyThe Scientific World Journal1537-744X2013-01-01201310.1155/2013/913654913654Glycyrrhetinic Acid-Poly(ethylene glycol)-glycyrrhetinic Acid Tri-Block Conjugates Based Self-Assembled Micelles for Hepatic Targeted Delivery of Poorly Water Soluble DrugFengbo Wu0Ting Xu1Chi Liu2Can Chen3Xiangrong Song4Yu Zheng5Gu He6Department of Pharmacy and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, No. 37 Guoxue Alley, Chengdu, Sichuan 610041, ChinaDepartment of Pharmacy and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, No. 37 Guoxue Alley, Chengdu, Sichuan 610041, ChinaDepartment of Pharmacy and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, No. 37 Guoxue Alley, Chengdu, Sichuan 610041, ChinaThe First Affiliated Hospital of Chengdu Medical College, Chengdu, Sichuan 610500, ChinaDepartment of Pharmacy and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, No. 37 Guoxue Alley, Chengdu, Sichuan 610041, ChinaDepartment of Pharmacy and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, No. 37 Guoxue Alley, Chengdu, Sichuan 610041, ChinaDepartment of Pharmacy and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, No. 37 Guoxue Alley, Chengdu, Sichuan 610041, ChinaThe triblock 18β-glycyrrhetinic acid-poly(ethylene glycol)-18β-glycyrrhetinic acid conjugates (GA-PEG-GA) based self-assembled micelles were synthesized and characterized by FTIR, NMR, transmission electron microscopy, and particle size analysis. The GA-PEG-GA conjugates having the critical micelle concentration of M were used to form nanosized micelles, with mean diameters of 159.21 ± 2.2 nm, and then paclitaxel (PTX) was incorporated into GA-PEG-GA micelles by self-assembly method. The physicochemical properties of the PTX loaded GA-PEG-GA micelles were evaluated including in vitro cellular uptake, cytotoxicity, drug release profile, and in vivo tissue distribution. The results demonstrate that the GA-PEG-GA micelles had low cytotoxicity and good ability of selectively delivering drug to hepatic cells in vitro and in vivo by the targeting moiety glycyrrhetinic acid. In conclusion, the GA-PEG-GA conjugates have potential medical applications for targeted delivery of poor soluble drug delivery.http://dx.doi.org/10.1155/2013/913654 |
| spellingShingle | Fengbo Wu Ting Xu Chi Liu Can Chen Xiangrong Song Yu Zheng Gu He Glycyrrhetinic Acid-Poly(ethylene glycol)-glycyrrhetinic Acid Tri-Block Conjugates Based Self-Assembled Micelles for Hepatic Targeted Delivery of Poorly Water Soluble Drug The Scientific World Journal |
| title | Glycyrrhetinic Acid-Poly(ethylene glycol)-glycyrrhetinic Acid Tri-Block Conjugates Based Self-Assembled Micelles for Hepatic Targeted Delivery of Poorly Water Soluble Drug |
| title_full | Glycyrrhetinic Acid-Poly(ethylene glycol)-glycyrrhetinic Acid Tri-Block Conjugates Based Self-Assembled Micelles for Hepatic Targeted Delivery of Poorly Water Soluble Drug |
| title_fullStr | Glycyrrhetinic Acid-Poly(ethylene glycol)-glycyrrhetinic Acid Tri-Block Conjugates Based Self-Assembled Micelles for Hepatic Targeted Delivery of Poorly Water Soluble Drug |
| title_full_unstemmed | Glycyrrhetinic Acid-Poly(ethylene glycol)-glycyrrhetinic Acid Tri-Block Conjugates Based Self-Assembled Micelles for Hepatic Targeted Delivery of Poorly Water Soluble Drug |
| title_short | Glycyrrhetinic Acid-Poly(ethylene glycol)-glycyrrhetinic Acid Tri-Block Conjugates Based Self-Assembled Micelles for Hepatic Targeted Delivery of Poorly Water Soluble Drug |
| title_sort | glycyrrhetinic acid poly ethylene glycol glycyrrhetinic acid tri block conjugates based self assembled micelles for hepatic targeted delivery of poorly water soluble drug |
| url | http://dx.doi.org/10.1155/2013/913654 |
| work_keys_str_mv | AT fengbowu glycyrrhetinicacidpolyethyleneglycolglycyrrhetinicacidtriblockconjugatesbasedselfassembledmicellesforhepatictargeteddeliveryofpoorlywatersolubledrug AT tingxu glycyrrhetinicacidpolyethyleneglycolglycyrrhetinicacidtriblockconjugatesbasedselfassembledmicellesforhepatictargeteddeliveryofpoorlywatersolubledrug AT chiliu glycyrrhetinicacidpolyethyleneglycolglycyrrhetinicacidtriblockconjugatesbasedselfassembledmicellesforhepatictargeteddeliveryofpoorlywatersolubledrug AT canchen glycyrrhetinicacidpolyethyleneglycolglycyrrhetinicacidtriblockconjugatesbasedselfassembledmicellesforhepatictargeteddeliveryofpoorlywatersolubledrug AT xiangrongsong glycyrrhetinicacidpolyethyleneglycolglycyrrhetinicacidtriblockconjugatesbasedselfassembledmicellesforhepatictargeteddeliveryofpoorlywatersolubledrug AT yuzheng glycyrrhetinicacidpolyethyleneglycolglycyrrhetinicacidtriblockconjugatesbasedselfassembledmicellesforhepatictargeteddeliveryofpoorlywatersolubledrug AT guhe glycyrrhetinicacidpolyethyleneglycolglycyrrhetinicacidtriblockconjugatesbasedselfassembledmicellesforhepatictargeteddeliveryofpoorlywatersolubledrug |