Antimetastatic and Anti-Inflammatory Potentials of Essential Oil from Edible Ocimum sanctum Leaves
Antimetastatic and anti-inflammatory activities of Ocimum sanctum essential oil (OSEO) have been assessed in this study. OSEO at the concentration of 250 μg/mL and above showed a significant (P*<0.05) decrease in the number of migrated cancer cells. In addition, OSEO at concentration of 250 μg/mL...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1155/2014/239508 |
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| author | Thamilvaani Manaharan Ramaraj Thirugnanasampandan Rajarajeswaran Jayakumar Gunasekar Ramya Gogul Ramnath M. S. Kanthimathi |
| author_facet | Thamilvaani Manaharan Ramaraj Thirugnanasampandan Rajarajeswaran Jayakumar Gunasekar Ramya Gogul Ramnath M. S. Kanthimathi |
| author_sort | Thamilvaani Manaharan |
| collection | DOAJ |
| description | Antimetastatic and anti-inflammatory activities of Ocimum sanctum essential oil (OSEO) have been assessed in this study. OSEO at the concentration of 250 μg/mL and above showed a significant (P*<0.05) decrease in the number of migrated cancer cells. In addition, OSEO at concentration of 250 μg/mL and above suppressed MMP-9 activity in lipopolysaccharide (LPS) induced inflammatory cells. A dose-dependent downregulation of MMP-9 expression was observed with the treatment of OSEO compared to the control. Our findings indicate that OSEO has both antimetastatic and anti-inflammatory potentials, advocating further investigation for clinical applications in the treatment of inflammation associated cancer. |
| format | Article |
| id | doaj-art-cdc1a9c2d50b4bc089b10329084d9b55 |
| institution | Kabale University |
| issn | 2356-6140 1537-744X |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-cdc1a9c2d50b4bc089b10329084d9b552025-02-03T06:07:35ZengWileyThe Scientific World Journal2356-61401537-744X2014-01-01201410.1155/2014/239508239508Antimetastatic and Anti-Inflammatory Potentials of Essential Oil from Edible Ocimum sanctum LeavesThamilvaani Manaharan0Ramaraj Thirugnanasampandan1Rajarajeswaran Jayakumar2Gunasekar Ramya3Gogul Ramnath4M. S. Kanthimathi5Department of Molecular Medicine, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, MalaysiaDepartment of Biotechnology, Kongunadu Arts and Science College, GN Mills, Coimbatore, Tamil Nadu 641029, IndiaDepartment of Molecular Medicine, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, MalaysiaDepartment of Biotechnology, Kongunadu Arts and Science College, GN Mills, Coimbatore, Tamil Nadu 641029, IndiaDepartment of Biotechnology, Kongunadu Arts and Science College, GN Mills, Coimbatore, Tamil Nadu 641029, IndiaDepartment of Molecular Medicine, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, MalaysiaAntimetastatic and anti-inflammatory activities of Ocimum sanctum essential oil (OSEO) have been assessed in this study. OSEO at the concentration of 250 μg/mL and above showed a significant (P*<0.05) decrease in the number of migrated cancer cells. In addition, OSEO at concentration of 250 μg/mL and above suppressed MMP-9 activity in lipopolysaccharide (LPS) induced inflammatory cells. A dose-dependent downregulation of MMP-9 expression was observed with the treatment of OSEO compared to the control. Our findings indicate that OSEO has both antimetastatic and anti-inflammatory potentials, advocating further investigation for clinical applications in the treatment of inflammation associated cancer.http://dx.doi.org/10.1155/2014/239508 |
| spellingShingle | Thamilvaani Manaharan Ramaraj Thirugnanasampandan Rajarajeswaran Jayakumar Gunasekar Ramya Gogul Ramnath M. S. Kanthimathi Antimetastatic and Anti-Inflammatory Potentials of Essential Oil from Edible Ocimum sanctum Leaves The Scientific World Journal |
| title | Antimetastatic and Anti-Inflammatory Potentials of Essential Oil from Edible Ocimum sanctum Leaves |
| title_full | Antimetastatic and Anti-Inflammatory Potentials of Essential Oil from Edible Ocimum sanctum Leaves |
| title_fullStr | Antimetastatic and Anti-Inflammatory Potentials of Essential Oil from Edible Ocimum sanctum Leaves |
| title_full_unstemmed | Antimetastatic and Anti-Inflammatory Potentials of Essential Oil from Edible Ocimum sanctum Leaves |
| title_short | Antimetastatic and Anti-Inflammatory Potentials of Essential Oil from Edible Ocimum sanctum Leaves |
| title_sort | antimetastatic and anti inflammatory potentials of essential oil from edible ocimum sanctum leaves |
| url | http://dx.doi.org/10.1155/2014/239508 |
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