Mesenchymal Stem Cells Isolated from Adipose and Other Tissues: Basic Biological Properties and Clinical Applications
Mesenchymal stem cells (MSCs) are adult stem cells that were initially isolated from bone marrow. However, subsequent research has shown that other adult tissues also contain MSCs. MSCs originate from mesenchyme, which is embryonic tissue derived from the mesoderm. These cells actively proliferate,...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2012/461718 |
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| _version_ | 1832552048084647936 |
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| author | Hakan Orbay Morikuni Tobita Hiroshi Mizuno |
| author_facet | Hakan Orbay Morikuni Tobita Hiroshi Mizuno |
| author_sort | Hakan Orbay |
| collection | DOAJ |
| description | Mesenchymal stem cells (MSCs) are adult stem cells that were initially isolated from bone marrow. However, subsequent research has shown that other adult tissues also contain MSCs. MSCs originate from mesenchyme, which is embryonic tissue derived from the mesoderm. These cells actively proliferate, giving rise to new cells in some tissues, but remain quiescent in others. MSCs are capable of differentiating into multiple cell types including adipocytes, chondrocytes, osteocytes, and cardiomyocytes. Isolation and induction of these cells could provide a new therapeutic tool for replacing damaged or lost adult tissues. However, the biological properties and use of stem cells in a clinical setting must be well established before significant clinical benefits are obtained. This paper summarizes data on the biological properties of MSCs and discusses current and potential clinical applications. |
| format | Article |
| id | doaj-art-cdbfda82c91b4ed3a0fba62b24d0d60f |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-cdbfda82c91b4ed3a0fba62b24d0d60f2025-02-03T05:59:49ZengWileyStem Cells International1687-966X1687-96782012-01-01201210.1155/2012/461718461718Mesenchymal Stem Cells Isolated from Adipose and Other Tissues: Basic Biological Properties and Clinical ApplicationsHakan Orbay0Morikuni Tobita1Hiroshi Mizuno2Department of Plastic and Reconstructive Surgery, Nippon Medical School, Tokyo 113-0022, JapanDepartment of Dentistry and Oral Surgery, Self Defense Force Hospital, Yokosuka 237-0071, JapanDepartment of Plastic and Reconstructive Surgery, Juntendo University School of Medicine, Tokyo 1138421, JapanMesenchymal stem cells (MSCs) are adult stem cells that were initially isolated from bone marrow. However, subsequent research has shown that other adult tissues also contain MSCs. MSCs originate from mesenchyme, which is embryonic tissue derived from the mesoderm. These cells actively proliferate, giving rise to new cells in some tissues, but remain quiescent in others. MSCs are capable of differentiating into multiple cell types including adipocytes, chondrocytes, osteocytes, and cardiomyocytes. Isolation and induction of these cells could provide a new therapeutic tool for replacing damaged or lost adult tissues. However, the biological properties and use of stem cells in a clinical setting must be well established before significant clinical benefits are obtained. This paper summarizes data on the biological properties of MSCs and discusses current and potential clinical applications.http://dx.doi.org/10.1155/2012/461718 |
| spellingShingle | Hakan Orbay Morikuni Tobita Hiroshi Mizuno Mesenchymal Stem Cells Isolated from Adipose and Other Tissues: Basic Biological Properties and Clinical Applications Stem Cells International |
| title | Mesenchymal Stem Cells Isolated from Adipose and Other Tissues: Basic Biological Properties and Clinical Applications |
| title_full | Mesenchymal Stem Cells Isolated from Adipose and Other Tissues: Basic Biological Properties and Clinical Applications |
| title_fullStr | Mesenchymal Stem Cells Isolated from Adipose and Other Tissues: Basic Biological Properties and Clinical Applications |
| title_full_unstemmed | Mesenchymal Stem Cells Isolated from Adipose and Other Tissues: Basic Biological Properties and Clinical Applications |
| title_short | Mesenchymal Stem Cells Isolated from Adipose and Other Tissues: Basic Biological Properties and Clinical Applications |
| title_sort | mesenchymal stem cells isolated from adipose and other tissues basic biological properties and clinical applications |
| url | http://dx.doi.org/10.1155/2012/461718 |
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