Age-Related Changes in Trabecular and Cortical Bone Microstructure
The elderly population has substantially increased worldwide. Aging is a complex process, and the effects of aging are myriad and insidious, leading to progressive deterioration of various organs, including the skeleton. Age-related bone loss and resultant osteoporosis in the elderly population incr...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2013/213234 |
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| author | Huayue Chen Xiangrong Zhou Hiroshi Fujita Minoru Onozuka Kin-Ya Kubo |
| author_facet | Huayue Chen Xiangrong Zhou Hiroshi Fujita Minoru Onozuka Kin-Ya Kubo |
| author_sort | Huayue Chen |
| collection | DOAJ |
| description | The elderly population has substantially increased worldwide. Aging is a complex process, and the effects of aging are myriad and insidious, leading to progressive deterioration of various organs, including the skeleton. Age-related bone loss and resultant osteoporosis in the elderly population increase the risk for fractures and morbidity. Osteoporosis is one of the most common conditions associated with aging, and age is an independent risk factor for osteoporotic fractures. With the development of noninvasive imaging techniques such as computed tomography (CT), micro-CT, and high resolution peripheral quantitative CT (HR-pQCT), imaging of the bone architecture provides important information about age-related changes in bone microstructure and estimates of bone strength. In the past two decades, studies of human specimens using imaging techniques have revealed decreased bone strength in older adults compared with younger adults. The present paper addresses recently studied age-related changes in trabecular and cortical bone microstructure based primarily on HR-pQCT and micro-CT. We specifically focus on the three-dimensional microstructure of the vertebrae, femoral neck, and distal radius, which are common osteoporotic fracture sites. |
| format | Article |
| id | doaj-art-cdbce0d617e040b19ced67c771592860 |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-cdbce0d617e040b19ced67c7715928602025-02-03T06:01:06ZengWileyInternational Journal of Endocrinology1687-83371687-83452013-01-01201310.1155/2013/213234213234Age-Related Changes in Trabecular and Cortical Bone MicrostructureHuayue Chen0Xiangrong Zhou1Hiroshi Fujita2Minoru Onozuka3Kin-Ya Kubo4Department of Anatomy, Gifu University Graduate School of Medicine, 1-1 Yanagido, Gifu 501-1194, JapanDepartment of Intelligent Image Information, Gifu University Graduate School of Medicine, 1-1 Yanagido, Gifu 501-1194, JapanDepartment of Intelligent Image Information, Gifu University Graduate School of Medicine, 1-1 Yanagido, Gifu 501-1194, JapanNittai Jusei Medical College for Judo Therapeutics, 2-2-7 Yoga, Setagaya-ku, Tokyo 158-0097, JapanSeijoh University Graduate School of Health Care Studies, 2-172 Fukinodai, Tokai, Aichi 476-8588, JapanThe elderly population has substantially increased worldwide. Aging is a complex process, and the effects of aging are myriad and insidious, leading to progressive deterioration of various organs, including the skeleton. Age-related bone loss and resultant osteoporosis in the elderly population increase the risk for fractures and morbidity. Osteoporosis is one of the most common conditions associated with aging, and age is an independent risk factor for osteoporotic fractures. With the development of noninvasive imaging techniques such as computed tomography (CT), micro-CT, and high resolution peripheral quantitative CT (HR-pQCT), imaging of the bone architecture provides important information about age-related changes in bone microstructure and estimates of bone strength. In the past two decades, studies of human specimens using imaging techniques have revealed decreased bone strength in older adults compared with younger adults. The present paper addresses recently studied age-related changes in trabecular and cortical bone microstructure based primarily on HR-pQCT and micro-CT. We specifically focus on the three-dimensional microstructure of the vertebrae, femoral neck, and distal radius, which are common osteoporotic fracture sites.http://dx.doi.org/10.1155/2013/213234 |
| spellingShingle | Huayue Chen Xiangrong Zhou Hiroshi Fujita Minoru Onozuka Kin-Ya Kubo Age-Related Changes in Trabecular and Cortical Bone Microstructure International Journal of Endocrinology |
| title | Age-Related Changes in Trabecular and Cortical Bone Microstructure |
| title_full | Age-Related Changes in Trabecular and Cortical Bone Microstructure |
| title_fullStr | Age-Related Changes in Trabecular and Cortical Bone Microstructure |
| title_full_unstemmed | Age-Related Changes in Trabecular and Cortical Bone Microstructure |
| title_short | Age-Related Changes in Trabecular and Cortical Bone Microstructure |
| title_sort | age related changes in trabecular and cortical bone microstructure |
| url | http://dx.doi.org/10.1155/2013/213234 |
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