Hepatocellular Bile Salt Transport: Lessons from Cholestasis
Hepatic uptake and excretion of bile salts and several nonbile salt organic anions (eg, bilirubin) are mediated by a distinct set of polarized transport systems at the basolateral and apical plasma membrane domains of hepatocytes and bile duct epithelial cells (cholangiocytes). With the increasing a...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Wiley
2000-01-01
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| Series: | Canadian Journal of Gastroenterology |
| Online Access: | http://dx.doi.org/10.1155/2000/870929 |
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| _version_ | 1832565128972730368 |
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| author | Michael Trauner Peter Fickert Rudolf E Stauber |
| author_facet | Michael Trauner Peter Fickert Rudolf E Stauber |
| author_sort | Michael Trauner |
| collection | DOAJ |
| description | Hepatic uptake and excretion of
bile salts and several nonbile salt organic anions (eg, bilirubin) are
mediated by a distinct set of polarized transport systems at the basolateral
and apical plasma membrane domains of hepatocytes and
bile duct epithelial cells (cholangiocytes). With the increasing
availability of molecular probes for these transporters, evidence
now exists that decreased or even absent expression of hepatobiliary
transport proteins in hepatocytes or cholangiocytes may
explain impaired transport function that results in hyperbilirubinemia
and cholestasis. This review summarizes the molecular defects
in hepatocellular membrane transporters that are associated with
hereditary and acquired forms of cholestatic liver disease. |
| format | Article |
| id | doaj-art-cdbb9d8b80074588bb26c9e575fecb02 |
| institution | Kabale University |
| issn | 0835-7900 |
| language | English |
| publishDate | 2000-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Journal of Gastroenterology |
| spelling | doaj-art-cdbb9d8b80074588bb26c9e575fecb022025-02-03T01:09:29ZengWileyCanadian Journal of Gastroenterology0835-79002000-01-0114Suppl D99D104D10.1155/2000/870929Hepatocellular Bile Salt Transport: Lessons from CholestasisMichael Trauner0Peter Fickert1Rudolf E Stauber2Division of Gastroenterology and Hepatology, Department of Internal Medicine, Karl-Franzens University School of Medicine, Graz, AustriaDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Karl-Franzens University School of Medicine, Graz, AustriaDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Karl-Franzens University School of Medicine, Graz, AustriaHepatic uptake and excretion of bile salts and several nonbile salt organic anions (eg, bilirubin) are mediated by a distinct set of polarized transport systems at the basolateral and apical plasma membrane domains of hepatocytes and bile duct epithelial cells (cholangiocytes). With the increasing availability of molecular probes for these transporters, evidence now exists that decreased or even absent expression of hepatobiliary transport proteins in hepatocytes or cholangiocytes may explain impaired transport function that results in hyperbilirubinemia and cholestasis. This review summarizes the molecular defects in hepatocellular membrane transporters that are associated with hereditary and acquired forms of cholestatic liver disease.http://dx.doi.org/10.1155/2000/870929 |
| spellingShingle | Michael Trauner Peter Fickert Rudolf E Stauber Hepatocellular Bile Salt Transport: Lessons from Cholestasis Canadian Journal of Gastroenterology |
| title | Hepatocellular Bile Salt Transport: Lessons from Cholestasis |
| title_full | Hepatocellular Bile Salt Transport: Lessons from Cholestasis |
| title_fullStr | Hepatocellular Bile Salt Transport: Lessons from Cholestasis |
| title_full_unstemmed | Hepatocellular Bile Salt Transport: Lessons from Cholestasis |
| title_short | Hepatocellular Bile Salt Transport: Lessons from Cholestasis |
| title_sort | hepatocellular bile salt transport lessons from cholestasis |
| url | http://dx.doi.org/10.1155/2000/870929 |
| work_keys_str_mv | AT michaeltrauner hepatocellularbilesalttransportlessonsfromcholestasis AT peterfickert hepatocellularbilesalttransportlessonsfromcholestasis AT rudolfestauber hepatocellularbilesalttransportlessonsfromcholestasis |