Hepatocellular Bile Salt Transport: Lessons from Cholestasis
Hepatic uptake and excretion of bile salts and several nonbile salt organic anions (eg, bilirubin) are mediated by a distinct set of polarized transport systems at the basolateral and apical plasma membrane domains of hepatocytes and bile duct epithelial cells (cholangiocytes). With the increasing a...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2000-01-01
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| Series: | Canadian Journal of Gastroenterology |
| Online Access: | http://dx.doi.org/10.1155/2000/870929 |
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| Summary: | Hepatic uptake and excretion of
bile salts and several nonbile salt organic anions (eg, bilirubin) are
mediated by a distinct set of polarized transport systems at the basolateral
and apical plasma membrane domains of hepatocytes and
bile duct epithelial cells (cholangiocytes). With the increasing
availability of molecular probes for these transporters, evidence
now exists that decreased or even absent expression of hepatobiliary
transport proteins in hepatocytes or cholangiocytes may
explain impaired transport function that results in hyperbilirubinemia
and cholestasis. This review summarizes the molecular defects
in hepatocellular membrane transporters that are associated with
hereditary and acquired forms of cholestatic liver disease. |
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| ISSN: | 0835-7900 |