Effects of Particulate Matter Exhaust on Functional Parameters of Organ Systems and Reactive Oxygen Species: A Cross-Sectional Study
Background: From the day of industrial revolution and urbanization, exposure to diesel exhaust particles has become an environmental and occupational health concern as they contain a variety of nanoparticles which interfere with cellular function. Every organism on Earth has been exposed to minute f...
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Mashhad University of Medical Sciences
2024-12-01
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| Series: | Asia Pacific Journal of Medical Toxicology |
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| Online Access: | https://apjmt.mums.ac.ir/article_25497_ded5bce04fb2df839e1d2fda2e713b6b.pdf |
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| author | Manjula Shivanagappa SS Malini Thanmayi Mahadeshwara Prasad D. R. Mahadeshwara Prasad |
| author_facet | Manjula Shivanagappa SS Malini Thanmayi Mahadeshwara Prasad D. R. Mahadeshwara Prasad |
| author_sort | Manjula Shivanagappa |
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| description | Background: From the day of industrial revolution and urbanization, exposure to diesel exhaust particles has become an environmental and occupational health concern as they contain a variety of nanoparticles which interfere with cellular function. Every organism on Earth has been exposed to minute foreign particles which enter the organ system and disrupt the cellular processes, interact with membranes, cell organelles, DNA, and other proteins to establish a series of dynamic bio-physico-chemical interactions. We aimed to study the variation in inflammatory cellular components and oxidative stress markers among exposures along with the variation in functional parameters of the organs involved in detoxifying these nanoparticles, the renal and hepatic system.Methods: After the ethical clearance from Institutional Ethical Committee, IHEC-UOM No. 123PhD/2016-17, a cross-sectional study was undertaken in Molecular Reproductive and Human Genetics Lab, Manasa Gangothri, University of Mysore, Mysore, Karnataka, India during 2015-2019, among 500 male garage workers of age group 18-60years with history of exposure for 6-8 hours a day without using any protective aids during work, for past 6-12 years and 300 controls, who live in areas where they were sparsely exposed. Serum oxidative stress markers, hemogram, renal and liver functional parameters were analysed.Results: A significant variation was observed among the oxidative stress markers among the exposures with surge in malondialdehyde and reduction in superoxide dismutase and catalase with variation in cell count, renal and liver functional parameters (p ≤ 0.05).Conclusion: Diesel combustion nanoparticles induces oxidative stress which reflects hepato-renal aberration. |
| format | Article |
| id | doaj-art-cdb625053437442a9b4dd36e5643e0e2 |
| institution | Kabale University |
| issn | 2322-2611 2322-4320 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Mashhad University of Medical Sciences |
| record_format | Article |
| series | Asia Pacific Journal of Medical Toxicology |
| spelling | doaj-art-cdb625053437442a9b4dd36e5643e0e22025-02-01T06:56:21ZengMashhad University of Medical SciencesAsia Pacific Journal of Medical Toxicology2322-26112322-43202024-12-0113415115710.22038/apjmt.2025.82879.147425497Effects of Particulate Matter Exhaust on Functional Parameters of Organ Systems and Reactive Oxygen Species: A Cross-Sectional StudyManjula Shivanagappa0SS Malini1Thanmayi Mahadeshwara Prasad2D. R. Mahadeshwara Prasad3Department of Oral and Maxillo-Facial Surgery, JSS Dental College and Hospital, JSSAHER, Mysuru, Karnataka, IndiaDepartment of Studies in Genetics and Genomics, University of Mysore Manasagangothri, Mysuru, IndiaMedical student, Basaveshwara Medical College, Chitradurga, Karnataka, IndiaDepartment of Forensic Medicine & Toxicology, District Hospital & Epidemic Disease Hospital, KRS Road, Mysuru, Karnataka, IndiaBackground: From the day of industrial revolution and urbanization, exposure to diesel exhaust particles has become an environmental and occupational health concern as they contain a variety of nanoparticles which interfere with cellular function. Every organism on Earth has been exposed to minute foreign particles which enter the organ system and disrupt the cellular processes, interact with membranes, cell organelles, DNA, and other proteins to establish a series of dynamic bio-physico-chemical interactions. We aimed to study the variation in inflammatory cellular components and oxidative stress markers among exposures along with the variation in functional parameters of the organs involved in detoxifying these nanoparticles, the renal and hepatic system.Methods: After the ethical clearance from Institutional Ethical Committee, IHEC-UOM No. 123PhD/2016-17, a cross-sectional study was undertaken in Molecular Reproductive and Human Genetics Lab, Manasa Gangothri, University of Mysore, Mysore, Karnataka, India during 2015-2019, among 500 male garage workers of age group 18-60years with history of exposure for 6-8 hours a day without using any protective aids during work, for past 6-12 years and 300 controls, who live in areas where they were sparsely exposed. Serum oxidative stress markers, hemogram, renal and liver functional parameters were analysed.Results: A significant variation was observed among the oxidative stress markers among the exposures with surge in malondialdehyde and reduction in superoxide dismutase and catalase with variation in cell count, renal and liver functional parameters (p ≤ 0.05).Conclusion: Diesel combustion nanoparticles induces oxidative stress which reflects hepato-renal aberration.https://apjmt.mums.ac.ir/article_25497_ded5bce04fb2df839e1d2fda2e713b6b.pdfdiesel combustion nanoparticlesparticulate matteroxidative stressreactive oxygen species |
| spellingShingle | Manjula Shivanagappa SS Malini Thanmayi Mahadeshwara Prasad D. R. Mahadeshwara Prasad Effects of Particulate Matter Exhaust on Functional Parameters of Organ Systems and Reactive Oxygen Species: A Cross-Sectional Study Asia Pacific Journal of Medical Toxicology diesel combustion nanoparticles particulate matter oxidative stress reactive oxygen species |
| title | Effects of Particulate Matter Exhaust on Functional Parameters of Organ Systems and Reactive Oxygen Species: A Cross-Sectional Study |
| title_full | Effects of Particulate Matter Exhaust on Functional Parameters of Organ Systems and Reactive Oxygen Species: A Cross-Sectional Study |
| title_fullStr | Effects of Particulate Matter Exhaust on Functional Parameters of Organ Systems and Reactive Oxygen Species: A Cross-Sectional Study |
| title_full_unstemmed | Effects of Particulate Matter Exhaust on Functional Parameters of Organ Systems and Reactive Oxygen Species: A Cross-Sectional Study |
| title_short | Effects of Particulate Matter Exhaust on Functional Parameters of Organ Systems and Reactive Oxygen Species: A Cross-Sectional Study |
| title_sort | effects of particulate matter exhaust on functional parameters of organ systems and reactive oxygen species a cross sectional study |
| topic | diesel combustion nanoparticles particulate matter oxidative stress reactive oxygen species |
| url | https://apjmt.mums.ac.ir/article_25497_ded5bce04fb2df839e1d2fda2e713b6b.pdf |
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