Exacerbation of Pulmonary Fibrosis Following Single Lung Transplantation
Acute exacerbations of interstitial lung disease present as clinical deteriorations, with progressive hypoxemia and parenchymal consolidation not related to infection, heart failure or thromboembolic disease. Following single lung transplantation, patients receive maintenance immunosuppression, whic...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Canadian Respiratory Journal |
| Online Access: | http://dx.doi.org/10.1155/2012/258485 |
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| _version_ | 1832561318442303488 |
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| author | Dawei Yang Jennifer M Wilson Chunxue Bai John Yee Pearce G Wilcox Nasreen Khalil Robert D Levy |
| author_facet | Dawei Yang Jennifer M Wilson Chunxue Bai John Yee Pearce G Wilcox Nasreen Khalil Robert D Levy |
| author_sort | Dawei Yang |
| collection | DOAJ |
| description | Acute exacerbations of interstitial lung disease present as clinical deteriorations, with progressive hypoxemia and parenchymal consolidation not related to infection, heart failure or thromboembolic disease. Following single lung transplantation, patients receive maintenance immunosuppression, which could mitigate the development of acute exacerbations in the native lung. A 66-year-old man with fibrotic, nonspecific interstitial pneumonitis presented with fever, hypoxemia and parenchymal consolidation limited to the native lung four years after single lung transplantation. Investigations were negative for infection, heart failure and thromboembolic disease. The patient worsened over the course of one week despite broad-spectrum antimicrobial therapy, but subsequently improved promptly with augmentation of prednisone dosed to 50 mg daily and addition of N-acetylcysteine. Hence, the patient fulfilled the criteria for a diagnosis of an acute exacerbation of pulmonary fibrosis in his native lung. Clinicians should consider acute exacerbation of parenchymal lung disease of the native lung in the differential diagnosis of progressive respiratory deterioration following single lung transplantation for pulmonary fibrosis. |
| format | Article |
| id | doaj-art-cdb453d013e74b56995e1bd4ca9df297 |
| institution | Kabale University |
| issn | 1198-2241 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Respiratory Journal |
| spelling | doaj-art-cdb453d013e74b56995e1bd4ca9df2972025-02-03T01:25:24ZengWileyCanadian Respiratory Journal1198-22412012-01-01191e3e410.1155/2012/258485Exacerbation of Pulmonary Fibrosis Following Single Lung TransplantationDawei Yang0Jennifer M Wilson1Chunxue Bai2John Yee3Pearce G Wilcox4Nasreen Khalil5Robert D Levy6Division of Respiratory Medicine, Department of Medicine, University of British Columbia, Vancouver, British Columbia, CanadaDivision of Respiratory Medicine, Department of Medicine, University of British Columbia, Vancouver, British Columbia, CanadaDepartment of Pulmonary Medicine, Zhongshan Hospital, Fudan University, Shanghai, ChinaBritish Columbia Transplant, Vancouver, British Columbia, CanadaDivision of Respiratory Medicine, Department of Medicine, University of British Columbia, Vancouver, British Columbia, CanadaDivision of Respiratory Medicine, Department of Medicine, University of British Columbia, Vancouver, British Columbia, CanadaDivision of Respiratory Medicine, Department of Medicine, University of British Columbia, Vancouver, British Columbia, CanadaAcute exacerbations of interstitial lung disease present as clinical deteriorations, with progressive hypoxemia and parenchymal consolidation not related to infection, heart failure or thromboembolic disease. Following single lung transplantation, patients receive maintenance immunosuppression, which could mitigate the development of acute exacerbations in the native lung. A 66-year-old man with fibrotic, nonspecific interstitial pneumonitis presented with fever, hypoxemia and parenchymal consolidation limited to the native lung four years after single lung transplantation. Investigations were negative for infection, heart failure and thromboembolic disease. The patient worsened over the course of one week despite broad-spectrum antimicrobial therapy, but subsequently improved promptly with augmentation of prednisone dosed to 50 mg daily and addition of N-acetylcysteine. Hence, the patient fulfilled the criteria for a diagnosis of an acute exacerbation of pulmonary fibrosis in his native lung. Clinicians should consider acute exacerbation of parenchymal lung disease of the native lung in the differential diagnosis of progressive respiratory deterioration following single lung transplantation for pulmonary fibrosis.http://dx.doi.org/10.1155/2012/258485 |
| spellingShingle | Dawei Yang Jennifer M Wilson Chunxue Bai John Yee Pearce G Wilcox Nasreen Khalil Robert D Levy Exacerbation of Pulmonary Fibrosis Following Single Lung Transplantation Canadian Respiratory Journal |
| title | Exacerbation of Pulmonary Fibrosis Following Single Lung Transplantation |
| title_full | Exacerbation of Pulmonary Fibrosis Following Single Lung Transplantation |
| title_fullStr | Exacerbation of Pulmonary Fibrosis Following Single Lung Transplantation |
| title_full_unstemmed | Exacerbation of Pulmonary Fibrosis Following Single Lung Transplantation |
| title_short | Exacerbation of Pulmonary Fibrosis Following Single Lung Transplantation |
| title_sort | exacerbation of pulmonary fibrosis following single lung transplantation |
| url | http://dx.doi.org/10.1155/2012/258485 |
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