Biomarkers for Risk Stratification of Neoplastic Progression in Barrett Esophagus
Barrett esophagus (BE) is caused by chronic gastroesophageal reflux and predisposes to the development of esophageal adenocarcinoma through different grades of dysplasia. Only a subset of BE patients will finally develop esophageal adenocarcinoma. The majority will therefore not benefit from an endo...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2007-01-01
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| Series: | Cellular Oncology |
| Online Access: | http://dx.doi.org/10.1155/2007/814950 |
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| _version_ | 1832549615046492160 |
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| author | Marjon Kerkhof Johannes G. Kusters Herman van Dekken Ernst J. Kuipers Peter D. Siersema |
| author_facet | Marjon Kerkhof Johannes G. Kusters Herman van Dekken Ernst J. Kuipers Peter D. Siersema |
| author_sort | Marjon Kerkhof |
| collection | DOAJ |
| description | Barrett esophagus (BE) is caused by chronic gastroesophageal reflux and predisposes to the development of esophageal adenocarcinoma through different grades of dysplasia. Only a subset of BE patients will finally develop esophageal adenocarcinoma. The majority will therefore not benefit from an endoscopic surveillance program, based on the histological identification of dysplasia. Several studies have been performed to find additional biomarkers that can be used to detect the subgroup of patients with an increased risk of developing malignancy in BE. In this review, we will summarize the most promising tissue biomarkers, i.e. proliferation/cell cycle proteins, tumor suppressor genes, adhesion molecules, DNA ploidy status and inflammation associated markers, that can be used for risk stratification in BE, and discuss their respective clinical application. |
| format | Article |
| id | doaj-art-cdb0073f54f144a2b46910bd1422df68 |
| institution | Kabale University |
| issn | 1570-5870 1875-8606 |
| language | English |
| publishDate | 2007-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cellular Oncology |
| spelling | doaj-art-cdb0073f54f144a2b46910bd1422df682025-02-03T06:10:56ZengWileyCellular Oncology1570-58701875-86062007-01-0129650751710.1155/2007/814950Biomarkers for Risk Stratification of Neoplastic Progression in Barrett EsophagusMarjon Kerkhof0Johannes G. Kusters1Herman van Dekken2Ernst J. Kuipers3Peter D. Siersema4Department of Gastroenterology and Hepatology, Erasmus MC – University Medical Center Rotterdam, Rotterdam, The NetherlandsDepartment of Gastroenterology and Hepatology, Erasmus MC – University Medical Center Rotterdam, Rotterdam, The NetherlandsDepartment of Pathology, Erasmus MC – University Medical Center Rotterdam, Rotterdam, The NetherlandsDepartment of Gastroenterology and Hepatology, Erasmus MC – University Medical Center Rotterdam, Rotterdam, The NetherlandsDepartment of Gastroenterology and Hepatology, Erasmus MC – University Medical Center Rotterdam, Rotterdam, The NetherlandsBarrett esophagus (BE) is caused by chronic gastroesophageal reflux and predisposes to the development of esophageal adenocarcinoma through different grades of dysplasia. Only a subset of BE patients will finally develop esophageal adenocarcinoma. The majority will therefore not benefit from an endoscopic surveillance program, based on the histological identification of dysplasia. Several studies have been performed to find additional biomarkers that can be used to detect the subgroup of patients with an increased risk of developing malignancy in BE. In this review, we will summarize the most promising tissue biomarkers, i.e. proliferation/cell cycle proteins, tumor suppressor genes, adhesion molecules, DNA ploidy status and inflammation associated markers, that can be used for risk stratification in BE, and discuss their respective clinical application.http://dx.doi.org/10.1155/2007/814950 |
| spellingShingle | Marjon Kerkhof Johannes G. Kusters Herman van Dekken Ernst J. Kuipers Peter D. Siersema Biomarkers for Risk Stratification of Neoplastic Progression in Barrett Esophagus Cellular Oncology |
| title | Biomarkers for Risk Stratification of Neoplastic Progression in Barrett Esophagus |
| title_full | Biomarkers for Risk Stratification of Neoplastic Progression in Barrett Esophagus |
| title_fullStr | Biomarkers for Risk Stratification of Neoplastic Progression in Barrett Esophagus |
| title_full_unstemmed | Biomarkers for Risk Stratification of Neoplastic Progression in Barrett Esophagus |
| title_short | Biomarkers for Risk Stratification of Neoplastic Progression in Barrett Esophagus |
| title_sort | biomarkers for risk stratification of neoplastic progression in barrett esophagus |
| url | http://dx.doi.org/10.1155/2007/814950 |
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