Tumor Cells and Tumor-Associated Macrophages: Secreted Proteins as Potential Targets for Therapy
Inflammatory pathways, meant to defend the organism against infection and injury, as a byproduct, can promote an environment which favors tumor growth and metastasis. Tumor-associated macrophages (TAMs), which constitute a significant part of the tumor-infiltrating immune cells, have been linked to...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2011-01-01
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| Series: | Clinical and Developmental Immunology |
| Online Access: | http://dx.doi.org/10.1155/2011/565187 |
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| _version_ | 1832550305846263808 |
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| author | Marc Baay Anja Brouwer Patrick Pauwels Marc Peeters Filip Lardon |
| author_facet | Marc Baay Anja Brouwer Patrick Pauwels Marc Peeters Filip Lardon |
| author_sort | Marc Baay |
| collection | DOAJ |
| description | Inflammatory pathways, meant to defend the organism against infection and injury, as a byproduct, can promote an environment which favors tumor growth and metastasis. Tumor-associated macrophages (TAMs), which constitute a significant part of the tumor-infiltrating immune cells, have been linked to the growth, angiogenesis, and metastasis of a variety of cancers, most likely through polarization of TAMs to the M2 (alternative) phenotype. The interaction between tumor cells and macrophages provides opportunities for therapy. This paper will discuss secreted proteins as targets for intervention. |
| format | Article |
| id | doaj-art-cdac7f68e44e4b9287d090eced50efc6 |
| institution | Kabale University |
| issn | 1740-2522 1740-2530 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Developmental Immunology |
| spelling | doaj-art-cdac7f68e44e4b9287d090eced50efc62025-02-03T06:07:16ZengWileyClinical and Developmental Immunology1740-25221740-25302011-01-01201110.1155/2011/565187565187Tumor Cells and Tumor-Associated Macrophages: Secreted Proteins as Potential Targets for TherapyMarc Baay0Anja Brouwer1Patrick Pauwels2Marc Peeters3Filip Lardon4Center for Oncological Research Antwerp (CORE), University of Antwerp, Universiteitsplein 1, 2610 Wilrijk, BelgiumCenter for Oncological Research Antwerp (CORE), University of Antwerp, Universiteitsplein 1, 2610 Wilrijk, BelgiumCenter for Oncological Research Antwerp (CORE), University of Antwerp, Universiteitsplein 1, 2610 Wilrijk, BelgiumCenter for Oncological Research Antwerp (CORE), University of Antwerp, Universiteitsplein 1, 2610 Wilrijk, BelgiumCenter for Oncological Research Antwerp (CORE), University of Antwerp, Universiteitsplein 1, 2610 Wilrijk, BelgiumInflammatory pathways, meant to defend the organism against infection and injury, as a byproduct, can promote an environment which favors tumor growth and metastasis. Tumor-associated macrophages (TAMs), which constitute a significant part of the tumor-infiltrating immune cells, have been linked to the growth, angiogenesis, and metastasis of a variety of cancers, most likely through polarization of TAMs to the M2 (alternative) phenotype. The interaction between tumor cells and macrophages provides opportunities for therapy. This paper will discuss secreted proteins as targets for intervention.http://dx.doi.org/10.1155/2011/565187 |
| spellingShingle | Marc Baay Anja Brouwer Patrick Pauwels Marc Peeters Filip Lardon Tumor Cells and Tumor-Associated Macrophages: Secreted Proteins as Potential Targets for Therapy Clinical and Developmental Immunology |
| title | Tumor Cells and Tumor-Associated Macrophages: Secreted Proteins as Potential Targets for Therapy |
| title_full | Tumor Cells and Tumor-Associated Macrophages: Secreted Proteins as Potential Targets for Therapy |
| title_fullStr | Tumor Cells and Tumor-Associated Macrophages: Secreted Proteins as Potential Targets for Therapy |
| title_full_unstemmed | Tumor Cells and Tumor-Associated Macrophages: Secreted Proteins as Potential Targets for Therapy |
| title_short | Tumor Cells and Tumor-Associated Macrophages: Secreted Proteins as Potential Targets for Therapy |
| title_sort | tumor cells and tumor associated macrophages secreted proteins as potential targets for therapy |
| url | http://dx.doi.org/10.1155/2011/565187 |
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