Metformin versus insulin in gestational diabetes mellitus: a systematic review
Abstract Objective: The aim of this study is to assess the use of metformin with or without insulin for the treatment of Gestational Diabetes Mellitus compared to insulin alone. Data sources: This article consists of a systematic review of randomized clinical trials. The searches were carried out...
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Federação Brasileira das Sociedades de Ginecologia e Obstetrícia
2025-01-01
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| Series: | Revista Brasileira de Ginecologia e Obstetrícia |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-72032024000100323&lng=en&tlng=en |
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| author | Giovanna Noronha Berti Igor Gutschov Oviedo Garcia João Pedro Ruas Floriano de Toledo Júlia Rodrigues Tatemoto Lais Watanabe Marino Mariana de Medeiros Legori Sérgio Floriano de Toledo |
| author_facet | Giovanna Noronha Berti Igor Gutschov Oviedo Garcia João Pedro Ruas Floriano de Toledo Júlia Rodrigues Tatemoto Lais Watanabe Marino Mariana de Medeiros Legori Sérgio Floriano de Toledo |
| author_sort | Giovanna Noronha Berti |
| collection | DOAJ |
| description | Abstract Objective: The aim of this study is to assess the use of metformin with or without insulin for the treatment of Gestational Diabetes Mellitus compared to insulin alone. Data sources: This article consists of a systematic review of randomized clinical trials. The searches were carried out on MEDLINE including 7 studies, between 2010 to 2021. Study selection: Randomized clinical trials comparing metformin and insulin written in English, Spanish or Portuguese, with no time limit, were included. Data collection: Data was extracted from all the 7 articles and compared statistically when possible. Whenever data was not available or couldn't be statistically compared, the main results were described in detail. Data synthesis: Insulin alone is not superior than metformin with or without insulin on gestational diabetes mellitus. Conclusion: There is a potential viability of using metformin as an alternative compared to insulin alone in the treatment of Gestational Diabetes Mellitus. However, all assessed outcomes have a very low level of certainty of evidence and more studies are necessary to support these findings. |
| format | Article |
| id | doaj-art-cd9d6d2915c14aeba53b76d70ffa0c33 |
| institution | Kabale University |
| issn | 0100-7203 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Federação Brasileira das Sociedades de Ginecologia e Obstetrícia |
| record_format | Article |
| series | Revista Brasileira de Ginecologia e Obstetrícia |
| spelling | doaj-art-cd9d6d2915c14aeba53b76d70ffa0c332025-01-21T07:36:18ZengFederação Brasileira das Sociedades de Ginecologia e ObstetríciaRevista Brasileira de Ginecologia e Obstetrícia0100-72032025-01-014610.61622/rbgo/2024rbgo89Metformin versus insulin in gestational diabetes mellitus: a systematic reviewGiovanna Noronha Bertihttps://orcid.org/0009-0005-8004-1973Igor Gutschov Oviedo Garciahttps://orcid.org/0000-0003-4218-0049João Pedro Ruas Floriano de Toledohttps://orcid.org/0009-0007-7079-0086Júlia Rodrigues Tatemotohttps://orcid.org/0009-0009-1952-6903Lais Watanabe Marinohttps://orcid.org/0000-0001-9662-1597Mariana de Medeiros Legorihttps://orcid.org/0000-0003-2593-3627Sérgio Floriano de Toledohttps://orcid.org/0000-0002-3576-6765Abstract Objective: The aim of this study is to assess the use of metformin with or without insulin for the treatment of Gestational Diabetes Mellitus compared to insulin alone. Data sources: This article consists of a systematic review of randomized clinical trials. The searches were carried out on MEDLINE including 7 studies, between 2010 to 2021. Study selection: Randomized clinical trials comparing metformin and insulin written in English, Spanish or Portuguese, with no time limit, were included. Data collection: Data was extracted from all the 7 articles and compared statistically when possible. Whenever data was not available or couldn't be statistically compared, the main results were described in detail. Data synthesis: Insulin alone is not superior than metformin with or without insulin on gestational diabetes mellitus. Conclusion: There is a potential viability of using metformin as an alternative compared to insulin alone in the treatment of Gestational Diabetes Mellitus. However, all assessed outcomes have a very low level of certainty of evidence and more studies are necessary to support these findings.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-72032024000100323&lng=en&tlng=enGestational diabetesInsulin therapyMetforminPregnancy complications |
| spellingShingle | Giovanna Noronha Berti Igor Gutschov Oviedo Garcia João Pedro Ruas Floriano de Toledo Júlia Rodrigues Tatemoto Lais Watanabe Marino Mariana de Medeiros Legori Sérgio Floriano de Toledo Metformin versus insulin in gestational diabetes mellitus: a systematic review Revista Brasileira de Ginecologia e Obstetrícia Gestational diabetes Insulin therapy Metformin Pregnancy complications |
| title | Metformin versus insulin in gestational diabetes mellitus: a systematic review |
| title_full | Metformin versus insulin in gestational diabetes mellitus: a systematic review |
| title_fullStr | Metformin versus insulin in gestational diabetes mellitus: a systematic review |
| title_full_unstemmed | Metformin versus insulin in gestational diabetes mellitus: a systematic review |
| title_short | Metformin versus insulin in gestational diabetes mellitus: a systematic review |
| title_sort | metformin versus insulin in gestational diabetes mellitus a systematic review |
| topic | Gestational diabetes Insulin therapy Metformin Pregnancy complications |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-72032024000100323&lng=en&tlng=en |
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