Application of SeDeM expert systems in preformulation studies of pediatric ibuprofen ODT tablets
Pediatric, ibuprofen containing orodispersible tablets (ODTs) were prepared using the SeDeM expert system methodology. In order to facilitate formulation, directly compressible ibuprofen was employed (Ibuprofen DC 8TM) and characterized using its SeDeM profile. The mannitol based superdisintegrant L...
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| Format: | Article |
| Language: | English |
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Sciendo
2017-06-01
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| Series: | Acta Pharmaceutica |
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| Online Access: | https://doi.org/10.1515/acph-2017-0017 |
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| author | Sipos Emese Oltean Andrea Ramona Szabó Zoltán-István Rédai Emőke-Margit Nagy Gabriella Dónáth |
| author_facet | Sipos Emese Oltean Andrea Ramona Szabó Zoltán-István Rédai Emőke-Margit Nagy Gabriella Dónáth |
| author_sort | Sipos Emese |
| collection | DOAJ |
| description | Pediatric, ibuprofen containing orodispersible tablets (ODTs) were prepared using the SeDeM expert system methodology. In order to facilitate formulation, directly compressible ibuprofen was employed (Ibuprofen DC 8TM) and characterized using its SeDeM profile. The mannitol based superdisintegrant Ludiflash® was characterized by the SeDeM-ODT expert system, which also allowed calculation of the optimal excipient concentration in order to obtain suitable tablet hardness and disintegration time. After adding a sweetener and a standard combination of lubricants, the optimized formulation was directly compressed into tablets and evaluated in terms of tablet hardness, friability, disintegration time and dissolution profile. The SeDeM method was applied to determine the amount of corrective excipient (Ludiflash®) required for the compression of Ibuprofen DC 85TM in order to achieve suitable ODTs. Adequate tablet hardness, disintegration time, friability and dissolution profiles were found during tablet evaluation. |
| format | Article |
| id | doaj-art-cd97ed937bb94b0bb522ef5a1f9fab9f |
| institution | Kabale University |
| issn | 1846-9558 |
| language | English |
| publishDate | 2017-06-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Acta Pharmaceutica |
| spelling | doaj-art-cd97ed937bb94b0bb522ef5a1f9fab9f2025-02-02T15:49:15ZengSciendoActa Pharmaceutica1846-95582017-06-0167223724610.1515/acph-2017-0017acph-2017-0017Application of SeDeM expert systems in preformulation studies of pediatric ibuprofen ODT tabletsSipos Emese0Oltean Andrea Ramona1Szabó Zoltán-István2Rédai Emőke-Margit3Nagy Gabriella Dónáth4Department of Drugs Industry and Pharmaceutical Management Faculty of Pharmacy, University of Medicine and Pharmacy Tirgu Mureş. 540139 Targu Mures, RomaniaDepartment of Drugs Industry and Pharmaceutical Management Faculty of Pharmacy, University of Medicine and Pharmacy Tirgu Mureş, 540139 Targu Mures, RomaniaDepartment of Drugs Industry and Pharmaceutical Management Faculty of Pharmacy, University of Medicine and Pharmacy Tirgu Mureş, 540139 Targu Mures, RomaniaDepartment of Pharmaceutical Technology, Faculty of Pharmacy University of Medicine and Pharmacy Tirgu Mureş, 540139 Targu Mures, RomaniaDepartment of Physical Chemistry Faculty of Pharmacy, University of Medicine and Pharmacy Tirgu Mureş 540139, Targu Mures, RomaniaPediatric, ibuprofen containing orodispersible tablets (ODTs) were prepared using the SeDeM expert system methodology. In order to facilitate formulation, directly compressible ibuprofen was employed (Ibuprofen DC 8TM) and characterized using its SeDeM profile. The mannitol based superdisintegrant Ludiflash® was characterized by the SeDeM-ODT expert system, which also allowed calculation of the optimal excipient concentration in order to obtain suitable tablet hardness and disintegration time. After adding a sweetener and a standard combination of lubricants, the optimized formulation was directly compressed into tablets and evaluated in terms of tablet hardness, friability, disintegration time and dissolution profile. The SeDeM method was applied to determine the amount of corrective excipient (Ludiflash®) required for the compression of Ibuprofen DC 85TM in order to achieve suitable ODTs. Adequate tablet hardness, disintegration time, friability and dissolution profiles were found during tablet evaluation.https://doi.org/10.1515/acph-2017-0017ibuprofen dc 85tmludiflash®orodispersiblesedem |
| spellingShingle | Sipos Emese Oltean Andrea Ramona Szabó Zoltán-István Rédai Emőke-Margit Nagy Gabriella Dónáth Application of SeDeM expert systems in preformulation studies of pediatric ibuprofen ODT tablets Acta Pharmaceutica ibuprofen dc 85tm ludiflash® orodispersible sedem |
| title | Application of SeDeM expert systems in preformulation studies of pediatric ibuprofen ODT tablets |
| title_full | Application of SeDeM expert systems in preformulation studies of pediatric ibuprofen ODT tablets |
| title_fullStr | Application of SeDeM expert systems in preformulation studies of pediatric ibuprofen ODT tablets |
| title_full_unstemmed | Application of SeDeM expert systems in preformulation studies of pediatric ibuprofen ODT tablets |
| title_short | Application of SeDeM expert systems in preformulation studies of pediatric ibuprofen ODT tablets |
| title_sort | application of sedem expert systems in preformulation studies of pediatric ibuprofen odt tablets |
| topic | ibuprofen dc 85tm ludiflash® orodispersible sedem |
| url | https://doi.org/10.1515/acph-2017-0017 |
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