Assessment of Nutritional Status, Digestion and Absorption, and Quality of Life in Patients with Locally Advanced Pancreatic Cancer
Background and Aim. To provide a comprehensive quantitative assessment of nutritional status, digestion and absorption, and quality of life (QoL) in patients with locally advanced pancreatic cancer (LAPC). Methods. Sixteen patients with LAPC were prospectively assessed for weight loss (WL), body mas...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2017/6193765 |
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| author | J. E. Witvliet-van Nierop C. M. Lochtenberg-Potjes N. J. Wierdsma H. J. Scheffer G. Kazemier K. Ottens-Oussoren M. R. Meijerink M. A. E. de van der Schueren |
| author_facet | J. E. Witvliet-van Nierop C. M. Lochtenberg-Potjes N. J. Wierdsma H. J. Scheffer G. Kazemier K. Ottens-Oussoren M. R. Meijerink M. A. E. de van der Schueren |
| author_sort | J. E. Witvliet-van Nierop |
| collection | DOAJ |
| description | Background and Aim. To provide a comprehensive quantitative assessment of nutritional status, digestion and absorption, and quality of life (QoL) in patients with locally advanced pancreatic cancer (LAPC). Methods. Sixteen patients with LAPC were prospectively assessed for weight loss (WL), body mass index (BMI), fat-free mass index (FFMI), handgrip strength (HGS), dietary macronutrient intake, serum vitamin levels, resting and total energy expenditure (REE and TEE, indirect calorimetry), intestinal absorption capacity and fecal losses (bomb calorimetry), exocrine pancreatic function (fecal elastase-1 (FE1)), and gastrointestinal quality of life (GIQLI). Results. Two patients had a low BMI, 10 patients had WL > 10%/6 months, 8 patients had a FFMI < P10, and 8 patients had a HGS < P10. Measured REE was 33% higher (P=0.002) than predicted REE. TEE was significantly higher than daily energy intake (P=0.047). Malabsorption (<85%) of energy, fat, protein, and carbohydrates was observed in, respectively, 9, 8, 12, and 10 patients. FE1 levels were low (<200 μg/g) in 13 patients. Total QoL scored 71% (ample satisfactory). Conclusion. Patients with LAPC have a severely impaired nutritional status, most likely as a result of an increased REE and malabsorption due to exocrine pancreatic insufficiency. The trial is registered with PANFIRE clinicaltrials.gov NCT01939665. |
| format | Article |
| id | doaj-art-cd9318b0023e4c7f82f5b805ec99b5d4 |
| institution | Kabale University |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-cd9318b0023e4c7f82f5b805ec99b5d42025-02-03T06:05:59ZengWileyGastroenterology Research and Practice1687-61211687-630X2017-01-01201710.1155/2017/61937656193765Assessment of Nutritional Status, Digestion and Absorption, and Quality of Life in Patients with Locally Advanced Pancreatic CancerJ. E. Witvliet-van Nierop0C. M. Lochtenberg-Potjes1N. J. Wierdsma2H. J. Scheffer3G. Kazemier4K. Ottens-Oussoren5M. R. Meijerink6M. A. E. de van der Schueren7Department of Nutrition and Dietetics, Internal Medicine, VU University Medical Center, Amsterdam, NetherlandsDepartment of Nutrition and Dietetics, Internal Medicine, VU University Medical Center, Amsterdam, NetherlandsDepartment of Nutrition and Dietetics, Internal Medicine, VU University Medical Center, Amsterdam, NetherlandsDepartment of Radiology and Nuclear Medicine, VU University Medical Center, Amsterdam, NetherlandsDepartment of Surgery, VU University Medical Center, Amsterdam, NetherlandsDepartment of Nutrition and Dietetics, Internal Medicine, VU University Medical Center, Amsterdam, NetherlandsDepartment of Radiology and Nuclear Medicine, VU University Medical Center, Amsterdam, NetherlandsDepartment of Nutrition and Dietetics, Internal Medicine, VU University Medical Center, Amsterdam, NetherlandsBackground and Aim. To provide a comprehensive quantitative assessment of nutritional status, digestion and absorption, and quality of life (QoL) in patients with locally advanced pancreatic cancer (LAPC). Methods. Sixteen patients with LAPC were prospectively assessed for weight loss (WL), body mass index (BMI), fat-free mass index (FFMI), handgrip strength (HGS), dietary macronutrient intake, serum vitamin levels, resting and total energy expenditure (REE and TEE, indirect calorimetry), intestinal absorption capacity and fecal losses (bomb calorimetry), exocrine pancreatic function (fecal elastase-1 (FE1)), and gastrointestinal quality of life (GIQLI). Results. Two patients had a low BMI, 10 patients had WL > 10%/6 months, 8 patients had a FFMI < P10, and 8 patients had a HGS < P10. Measured REE was 33% higher (P=0.002) than predicted REE. TEE was significantly higher than daily energy intake (P=0.047). Malabsorption (<85%) of energy, fat, protein, and carbohydrates was observed in, respectively, 9, 8, 12, and 10 patients. FE1 levels were low (<200 μg/g) in 13 patients. Total QoL scored 71% (ample satisfactory). Conclusion. Patients with LAPC have a severely impaired nutritional status, most likely as a result of an increased REE and malabsorption due to exocrine pancreatic insufficiency. The trial is registered with PANFIRE clinicaltrials.gov NCT01939665.http://dx.doi.org/10.1155/2017/6193765 |
| spellingShingle | J. E. Witvliet-van Nierop C. M. Lochtenberg-Potjes N. J. Wierdsma H. J. Scheffer G. Kazemier K. Ottens-Oussoren M. R. Meijerink M. A. E. de van der Schueren Assessment of Nutritional Status, Digestion and Absorption, and Quality of Life in Patients with Locally Advanced Pancreatic Cancer Gastroenterology Research and Practice |
| title | Assessment of Nutritional Status, Digestion and Absorption, and Quality of Life in Patients with Locally Advanced Pancreatic Cancer |
| title_full | Assessment of Nutritional Status, Digestion and Absorption, and Quality of Life in Patients with Locally Advanced Pancreatic Cancer |
| title_fullStr | Assessment of Nutritional Status, Digestion and Absorption, and Quality of Life in Patients with Locally Advanced Pancreatic Cancer |
| title_full_unstemmed | Assessment of Nutritional Status, Digestion and Absorption, and Quality of Life in Patients with Locally Advanced Pancreatic Cancer |
| title_short | Assessment of Nutritional Status, Digestion and Absorption, and Quality of Life in Patients with Locally Advanced Pancreatic Cancer |
| title_sort | assessment of nutritional status digestion and absorption and quality of life in patients with locally advanced pancreatic cancer |
| url | http://dx.doi.org/10.1155/2017/6193765 |
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