A Case of Retroperitoneal Synovial Sarcoma in Pregnancy Treated with Antepartum Doxorubicin plus Ifosfamide Chemotherapy
We report a case of a 25-year-old pregnant woman diagnosed with a large, unresectable retroperitoneal synovial sarcoma. Successful neoadjuvant treatment with doxorubicin plus ifosfamide prepartum and continuing postpartum resulted in significant disease response allowing for later tumor resection. F...
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Case Reports in Oncological Medicine |
| Online Access: | http://dx.doi.org/10.1155/2021/9982171 |
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| author | Bradley H. Sipe Sarah G. Običan Evita Henderson-Jackson Nicole D. Riddle Rikesh Makanji Ricardo J. Gonzalez Andrew S. Brohl |
| author_facet | Bradley H. Sipe Sarah G. Običan Evita Henderson-Jackson Nicole D. Riddle Rikesh Makanji Ricardo J. Gonzalez Andrew S. Brohl |
| author_sort | Bradley H. Sipe |
| collection | DOAJ |
| description | We report a case of a 25-year-old pregnant woman diagnosed with a large, unresectable retroperitoneal synovial sarcoma. Successful neoadjuvant treatment with doxorubicin plus ifosfamide prepartum and continuing postpartum resulted in significant disease response allowing for later tumor resection. Following the first prepartum chemotherapy cycle, a decreased amniotic fluid index was noted, representing a potential complication of chemotherapy. Induction of labor was performed at 33 weeks gestation with excellent outcome in the newborn. This case highlights the complex medical decision-making process in the setting of cancer diagnosed during pregnancy, balancing oncologic and obstetric concerns, and to our knowledge is only the second reported case of synovial sarcoma treated with neoadjuvant cytotoxic chemotherapy in the antepartum period. |
| format | Article |
| id | doaj-art-cd8f9379527d4fb3b8c6124ee8b5f633 |
| institution | Kabale University |
| issn | 2090-6706 2090-6714 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Oncological Medicine |
| spelling | doaj-art-cd8f9379527d4fb3b8c6124ee8b5f6332025-02-03T05:44:45ZengWileyCase Reports in Oncological Medicine2090-67062090-67142021-01-01202110.1155/2021/99821719982171A Case of Retroperitoneal Synovial Sarcoma in Pregnancy Treated with Antepartum Doxorubicin plus Ifosfamide ChemotherapyBradley H. Sipe0Sarah G. Običan1Evita Henderson-Jackson2Nicole D. Riddle3Rikesh Makanji4Ricardo J. Gonzalez5Andrew S. Brohl6Department of Obstetrics and Gynecology, Morsani College of Medicine, University of South Florida, Tampa, Florida, USADepartment of Obstetrics and Gynecology, Morsani College of Medicine, University of South Florida, Tampa, Florida, USADepartment of Anatomic Pathology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USADepartment of Pathology, Morsani College of Medicine, University of South Florida, Tampa, Florida, USADiagnostic Imaging, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USASarcoma Department, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USASarcoma Department, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USAWe report a case of a 25-year-old pregnant woman diagnosed with a large, unresectable retroperitoneal synovial sarcoma. Successful neoadjuvant treatment with doxorubicin plus ifosfamide prepartum and continuing postpartum resulted in significant disease response allowing for later tumor resection. Following the first prepartum chemotherapy cycle, a decreased amniotic fluid index was noted, representing a potential complication of chemotherapy. Induction of labor was performed at 33 weeks gestation with excellent outcome in the newborn. This case highlights the complex medical decision-making process in the setting of cancer diagnosed during pregnancy, balancing oncologic and obstetric concerns, and to our knowledge is only the second reported case of synovial sarcoma treated with neoadjuvant cytotoxic chemotherapy in the antepartum period.http://dx.doi.org/10.1155/2021/9982171 |
| spellingShingle | Bradley H. Sipe Sarah G. Običan Evita Henderson-Jackson Nicole D. Riddle Rikesh Makanji Ricardo J. Gonzalez Andrew S. Brohl A Case of Retroperitoneal Synovial Sarcoma in Pregnancy Treated with Antepartum Doxorubicin plus Ifosfamide Chemotherapy Case Reports in Oncological Medicine |
| title | A Case of Retroperitoneal Synovial Sarcoma in Pregnancy Treated with Antepartum Doxorubicin plus Ifosfamide Chemotherapy |
| title_full | A Case of Retroperitoneal Synovial Sarcoma in Pregnancy Treated with Antepartum Doxorubicin plus Ifosfamide Chemotherapy |
| title_fullStr | A Case of Retroperitoneal Synovial Sarcoma in Pregnancy Treated with Antepartum Doxorubicin plus Ifosfamide Chemotherapy |
| title_full_unstemmed | A Case of Retroperitoneal Synovial Sarcoma in Pregnancy Treated with Antepartum Doxorubicin plus Ifosfamide Chemotherapy |
| title_short | A Case of Retroperitoneal Synovial Sarcoma in Pregnancy Treated with Antepartum Doxorubicin plus Ifosfamide Chemotherapy |
| title_sort | case of retroperitoneal synovial sarcoma in pregnancy treated with antepartum doxorubicin plus ifosfamide chemotherapy |
| url | http://dx.doi.org/10.1155/2021/9982171 |
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