A Unifying Theory for SIDS
The Sudden Infant Death Syndrome (SIDS) has four distinctive characteristics that must be explained by any theory proposed for it. (1) A characteristic male fraction of approximately 0.61 for all postneonatal SIDS in the US; (2) a distinctive lognormal-type age distribution arising from zero at bir...
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| Format: | Article |
| Language: | English |
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Wiley
2009-01-01
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| Series: | International Journal of Pediatrics |
| Online Access: | http://dx.doi.org/10.1155/2009/368270 |
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| author | David T. Mage Maria Donner |
| author_facet | David T. Mage Maria Donner |
| author_sort | David T. Mage |
| collection | DOAJ |
| description | The Sudden Infant Death Syndrome (SIDS) has four distinctive characteristics that must be explained by any theory proposed for it.
(1) A characteristic male fraction of approximately 0.61 for all postneonatal SIDS in the US; (2) a distinctive lognormal-type age distribution arising from zero at birth, mode at about 2 months, median at about 3 months, and an exponential decrease with age going towards zero beyond one year; (3) a marked decrease in SIDS rate from the discovery that changing the recommended infant sleep position from prone to supine reduced the rate of SIDS, but it did not change the form of the age or gender distributions cited above; (4) a seasonal variation, maximal in winter and minimal in summer, that implies subsets of SIDS displaying evidence of seasonal low-grade respiratory infection and nonseasonal neurological prematurity. A quadruple-risk model is presented that fits these conditions but requires confirmatory testing by finding a dominant X-linked allele protective against cerebral anoxia that is missing in SIDS. |
| format | Article |
| id | doaj-art-cd8a57a4580143269630778aa35c587d |
| institution | Kabale University |
| issn | 1687-9740 1687-9759 |
| language | English |
| publishDate | 2009-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Pediatrics |
| spelling | doaj-art-cd8a57a4580143269630778aa35c587d2025-02-03T01:23:00ZengWileyInternational Journal of Pediatrics1687-97401687-97592009-01-01200910.1155/2009/368270368270A Unifying Theory for SIDSDavid T. Mage0Maria Donner1A. I. duPont Hospital for Children, Biomolecular Core Laboratory, 1600 Rockland Road, Wilmington, DE 19803, USADuPont Haskell Global Centers for Health & Environmental Sciences, Investigative Sciences, Newark, DE 19711, USAThe Sudden Infant Death Syndrome (SIDS) has four distinctive characteristics that must be explained by any theory proposed for it. (1) A characteristic male fraction of approximately 0.61 for all postneonatal SIDS in the US; (2) a distinctive lognormal-type age distribution arising from zero at birth, mode at about 2 months, median at about 3 months, and an exponential decrease with age going towards zero beyond one year; (3) a marked decrease in SIDS rate from the discovery that changing the recommended infant sleep position from prone to supine reduced the rate of SIDS, but it did not change the form of the age or gender distributions cited above; (4) a seasonal variation, maximal in winter and minimal in summer, that implies subsets of SIDS displaying evidence of seasonal low-grade respiratory infection and nonseasonal neurological prematurity. A quadruple-risk model is presented that fits these conditions but requires confirmatory testing by finding a dominant X-linked allele protective against cerebral anoxia that is missing in SIDS.http://dx.doi.org/10.1155/2009/368270 |
| spellingShingle | David T. Mage Maria Donner A Unifying Theory for SIDS International Journal of Pediatrics |
| title | A Unifying Theory for SIDS |
| title_full | A Unifying Theory for SIDS |
| title_fullStr | A Unifying Theory for SIDS |
| title_full_unstemmed | A Unifying Theory for SIDS |
| title_short | A Unifying Theory for SIDS |
| title_sort | unifying theory for sids |
| url | http://dx.doi.org/10.1155/2009/368270 |
| work_keys_str_mv | AT davidtmage aunifyingtheoryforsids AT mariadonner aunifyingtheoryforsids AT davidtmage unifyingtheoryforsids AT mariadonner unifyingtheoryforsids |