Chinese Herbal Medicine in Ameliorating Diabetic Kidney Disease via Activating Autophagy
Diabetic kidney disease (DKD), a leading cause of end-stage renal disease (ESRD), has become a serious public health problem worldwide and lacks effective therapies due to its complex pathogenesis. Recent studies suggested defective autophagy involved in the pathogenesis and progression of DKD. Chin...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2019-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2019/9030893 |
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| _version_ | 1832566994248925184 |
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| author | Yuyang Wang Hailing Zhao Qian Wang Xuefeng Zhou Xiaoguang Lu Tongtong Liu Yongli Zhan Ping Li |
| author_facet | Yuyang Wang Hailing Zhao Qian Wang Xuefeng Zhou Xiaoguang Lu Tongtong Liu Yongli Zhan Ping Li |
| author_sort | Yuyang Wang |
| collection | DOAJ |
| description | Diabetic kidney disease (DKD), a leading cause of end-stage renal disease (ESRD), has become a serious public health problem worldwide and lacks effective therapies due to its complex pathogenesis. Recent studies suggested defective autophagy involved in the pathogenesis and progression of DKD. Chinese herbal medicine, as an emerging option for the treatment of DKD, could improve diabetic kidney injury by activating autophagy. In this review, we briefly summarize underlying mechanisms of autophagy dysregulation in DKD, including AMP-activated protein kinase (AMPK), the mechanistic target of rapamycin (mTOR), and the sirtuin (Sirt) pathways, and we particularly concentrate on the current status of Chinese herbal medicine treating DKD by regulating autophagy. The advances in our understanding regarding the treatment of DKD via regulating autophagy with Chinese herbal medicine will enhance the clinical application of Chinese medicine as well as discovery of novel therapeutic agents for diabetic patients. |
| format | Article |
| id | doaj-art-cd86534cc21c4edf8a86046d8d22b1cb |
| institution | Kabale University |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-cd86534cc21c4edf8a86046d8d22b1cb2025-02-03T01:02:43ZengWileyJournal of Diabetes Research2314-67452314-67532019-01-01201910.1155/2019/90308939030893Chinese Herbal Medicine in Ameliorating Diabetic Kidney Disease via Activating AutophagyYuyang Wang0Hailing Zhao1Qian Wang2Xuefeng Zhou3Xiaoguang Lu4Tongtong Liu5Yongli Zhan6Ping Li7Department of Nephrology, Guang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, ChinaBeijing Key Laboratory for Immune-Mediated Inflammatory Diseases, Institute of Clinical Medical Sciences, China-Japan Friendship Hospital, Beijing 100029, ChinaBeijing Key Laboratory for Immune-Mediated Inflammatory Diseases, Institute of Clinical Medical Sciences, China-Japan Friendship Hospital, Beijing 100029, ChinaBeijing Key Laboratory for Immune-Mediated Inflammatory Diseases, Institute of Clinical Medical Sciences, China-Japan Friendship Hospital, Beijing 100029, ChinaDepartment of Nephrology, Guang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, ChinaDepartment of Nephrology, Guang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, ChinaDepartment of Nephrology, Guang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, ChinaBeijing Key Laboratory for Immune-Mediated Inflammatory Diseases, Institute of Clinical Medical Sciences, China-Japan Friendship Hospital, Beijing 100029, ChinaDiabetic kidney disease (DKD), a leading cause of end-stage renal disease (ESRD), has become a serious public health problem worldwide and lacks effective therapies due to its complex pathogenesis. Recent studies suggested defective autophagy involved in the pathogenesis and progression of DKD. Chinese herbal medicine, as an emerging option for the treatment of DKD, could improve diabetic kidney injury by activating autophagy. In this review, we briefly summarize underlying mechanisms of autophagy dysregulation in DKD, including AMP-activated protein kinase (AMPK), the mechanistic target of rapamycin (mTOR), and the sirtuin (Sirt) pathways, and we particularly concentrate on the current status of Chinese herbal medicine treating DKD by regulating autophagy. The advances in our understanding regarding the treatment of DKD via regulating autophagy with Chinese herbal medicine will enhance the clinical application of Chinese medicine as well as discovery of novel therapeutic agents for diabetic patients.http://dx.doi.org/10.1155/2019/9030893 |
| spellingShingle | Yuyang Wang Hailing Zhao Qian Wang Xuefeng Zhou Xiaoguang Lu Tongtong Liu Yongli Zhan Ping Li Chinese Herbal Medicine in Ameliorating Diabetic Kidney Disease via Activating Autophagy Journal of Diabetes Research |
| title | Chinese Herbal Medicine in Ameliorating Diabetic Kidney Disease via Activating Autophagy |
| title_full | Chinese Herbal Medicine in Ameliorating Diabetic Kidney Disease via Activating Autophagy |
| title_fullStr | Chinese Herbal Medicine in Ameliorating Diabetic Kidney Disease via Activating Autophagy |
| title_full_unstemmed | Chinese Herbal Medicine in Ameliorating Diabetic Kidney Disease via Activating Autophagy |
| title_short | Chinese Herbal Medicine in Ameliorating Diabetic Kidney Disease via Activating Autophagy |
| title_sort | chinese herbal medicine in ameliorating diabetic kidney disease via activating autophagy |
| url | http://dx.doi.org/10.1155/2019/9030893 |
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