Inverse Occlusion: A Binocularly Motivated Treatment for Amblyopia
Recent laboratory findings suggest that short-term patching of the amblyopic eye (i.e., inverse occlusion) results in a larger and more sustained improvement in the binocular balance compared with normal controls. In this study, we investigate the cumulative effects of the short-term inverse occlusi...
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| Language: | English |
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Wiley
2019-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2019/5157628 |
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| author | Jiawei Zhou Zhifen He Yidong Wu Yiya Chen Xiaoxin Chen Yunjie Liang Yu Mao Zhimo Yao Fan Lu Jia Qu Robert F. Hess |
| author_facet | Jiawei Zhou Zhifen He Yidong Wu Yiya Chen Xiaoxin Chen Yunjie Liang Yu Mao Zhimo Yao Fan Lu Jia Qu Robert F. Hess |
| author_sort | Jiawei Zhou |
| collection | DOAJ |
| description | Recent laboratory findings suggest that short-term patching of the amblyopic eye (i.e., inverse occlusion) results in a larger and more sustained improvement in the binocular balance compared with normal controls. In this study, we investigate the cumulative effects of the short-term inverse occlusion in adults and old children with amblyopia. This is a prospective cohort study of 18 amblyopes (10-35 years old; 2 with strabismus) who have been subjected to 2 hours/day of inverse occlusion for 2 months. Patients who required refractive correction or whose refractive correction needed updating were given a 2-month period of refractive adaptation. The primary outcome measure was the binocular balance which was measured using a phase combination task; the secondary outcome measures were the best-corrected visual acuity which was measured with a Tumbling E acuity chart and converted to logMAR units and the stereoacuity which was measured with the Random-dot preschool stereogram test. The average binocular gain was 0.11 in terms of the effective contrast ratio (z=−2.344, p=0.019, 2-tailed related samples Wilcoxon Signed Rank Test). The average acuity gain was 0.13 logMAR equivalent (t17=4.76, p<0.001, 2-tailed paired samples t-test). The average stereoacuity gain was 339 arc seconds (z=−2.533, p=0.011). Based on more recent research concerning adult ocular dominance plasticity, we conclude that inverse occlusion in adults and old children with amblyopia does produce long-term gains to binocular balance and that acuity and stereopsis can improve in some subjects. |
| format | Article |
| id | doaj-art-cd7c3a60ad08479cb7132b0e16679c29 |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-cd7c3a60ad08479cb7132b0e16679c292025-02-03T01:28:35ZengWileyNeural Plasticity2090-59041687-54432019-01-01201910.1155/2019/51576285157628Inverse Occlusion: A Binocularly Motivated Treatment for AmblyopiaJiawei Zhou0Zhifen He1Yidong Wu2Yiya Chen3Xiaoxin Chen4Yunjie Liang5Yu Mao6Zhimo Yao7Fan Lu8Jia Qu9Robert F. Hess10School of Ophthalmology and Optometry and Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang 325003, ChinaSchool of Ophthalmology and Optometry and Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang 325003, ChinaSchool of Ophthalmology and Optometry and Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang 325003, ChinaSchool of Ophthalmology and Optometry and Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang 325003, ChinaSchool of Ophthalmology and Optometry and Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang 325003, ChinaSchool of Ophthalmology and Optometry and Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang 325003, ChinaSchool of Ophthalmology and Optometry and Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang 325003, ChinaSchool of Ophthalmology and Optometry and Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang 325003, ChinaSchool of Ophthalmology and Optometry and Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang 325003, ChinaSchool of Ophthalmology and Optometry and Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang 325003, ChinaMcGill University, McGill Vision Research, Department of Ophthalmology, Quebec, Montreal, H3G 1A4, CanadaRecent laboratory findings suggest that short-term patching of the amblyopic eye (i.e., inverse occlusion) results in a larger and more sustained improvement in the binocular balance compared with normal controls. In this study, we investigate the cumulative effects of the short-term inverse occlusion in adults and old children with amblyopia. This is a prospective cohort study of 18 amblyopes (10-35 years old; 2 with strabismus) who have been subjected to 2 hours/day of inverse occlusion for 2 months. Patients who required refractive correction or whose refractive correction needed updating were given a 2-month period of refractive adaptation. The primary outcome measure was the binocular balance which was measured using a phase combination task; the secondary outcome measures were the best-corrected visual acuity which was measured with a Tumbling E acuity chart and converted to logMAR units and the stereoacuity which was measured with the Random-dot preschool stereogram test. The average binocular gain was 0.11 in terms of the effective contrast ratio (z=−2.344, p=0.019, 2-tailed related samples Wilcoxon Signed Rank Test). The average acuity gain was 0.13 logMAR equivalent (t17=4.76, p<0.001, 2-tailed paired samples t-test). The average stereoacuity gain was 339 arc seconds (z=−2.533, p=0.011). Based on more recent research concerning adult ocular dominance plasticity, we conclude that inverse occlusion in adults and old children with amblyopia does produce long-term gains to binocular balance and that acuity and stereopsis can improve in some subjects.http://dx.doi.org/10.1155/2019/5157628 |
| spellingShingle | Jiawei Zhou Zhifen He Yidong Wu Yiya Chen Xiaoxin Chen Yunjie Liang Yu Mao Zhimo Yao Fan Lu Jia Qu Robert F. Hess Inverse Occlusion: A Binocularly Motivated Treatment for Amblyopia Neural Plasticity |
| title | Inverse Occlusion: A Binocularly Motivated Treatment for Amblyopia |
| title_full | Inverse Occlusion: A Binocularly Motivated Treatment for Amblyopia |
| title_fullStr | Inverse Occlusion: A Binocularly Motivated Treatment for Amblyopia |
| title_full_unstemmed | Inverse Occlusion: A Binocularly Motivated Treatment for Amblyopia |
| title_short | Inverse Occlusion: A Binocularly Motivated Treatment for Amblyopia |
| title_sort | inverse occlusion a binocularly motivated treatment for amblyopia |
| url | http://dx.doi.org/10.1155/2019/5157628 |
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