Biological Properties and the Role of IL-25 in Disease Pathogenesis
The interleukin- (IL-) 17 superfamily, a T cell-derived cytokine, consists of 6 ligands (IL-17A–IL-17F) and 5 receptors (IL-17RA–IL-17RE). IL-17A, a prototype member of this family, is involved in the pathogenesis of allergies, autoimmune diseases, allograft transplantations, and malignancies. By co...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2018/6519465 |
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| _version_ | 1832558064514891776 |
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| author | Yuwan Liu Zewei Shao Guoqiang Shangguan Qingli Bie Bin Zhang |
| author_facet | Yuwan Liu Zewei Shao Guoqiang Shangguan Qingli Bie Bin Zhang |
| author_sort | Yuwan Liu |
| collection | DOAJ |
| description | The interleukin- (IL-) 17 superfamily, a T cell-derived cytokine, consists of 6 ligands (IL-17A–IL-17F) and 5 receptors (IL-17RA–IL-17RE). IL-17A, a prototype member of this family, is involved in the pathogenesis of allergies, autoimmune diseases, allograft transplantations, and malignancies. By contrast, IL-17B is reported to be closely related to certain diseases, particularly tumors such as breast cancer, gastric cancer, and pancreatic cancer. Recently, the biological function of IL-17E (also called IL-25) in disease, particularly airway diseases, has attracted the attention of researchers. However, studies on IL-25 are scant. In this review, we detail the structural characteristics, expression patterns, responder cells, biological properties, and role of IL-25 in disease pathogenesis. |
| format | Article |
| id | doaj-art-cd7b3b4ff1e74923847d99eb44e923aa |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-cd7b3b4ff1e74923847d99eb44e923aa2025-02-03T01:33:22ZengWileyJournal of Immunology Research2314-88612314-71562018-01-01201810.1155/2018/65194656519465Biological Properties and the Role of IL-25 in Disease PathogenesisYuwan Liu0Zewei Shao1Guoqiang Shangguan2Qingli Bie3Bin Zhang4Department of Laboratory Medicine, Affiliated Hospital of Jining Medical University, Jining, Shandong, ChinaInstitute of Forensic Medicine and Laboratory Medicine, Jining Medical University, Jining, Shandong, ChinaInstitute of Forensic Medicine and Laboratory Medicine, Jining Medical University, Jining, Shandong, ChinaDepartment of Laboratory Medicine, Affiliated Hospital of Jining Medical University, Jining, Shandong, ChinaDepartment of Laboratory Medicine, Affiliated Hospital of Jining Medical University, Jining, Shandong, ChinaThe interleukin- (IL-) 17 superfamily, a T cell-derived cytokine, consists of 6 ligands (IL-17A–IL-17F) and 5 receptors (IL-17RA–IL-17RE). IL-17A, a prototype member of this family, is involved in the pathogenesis of allergies, autoimmune diseases, allograft transplantations, and malignancies. By contrast, IL-17B is reported to be closely related to certain diseases, particularly tumors such as breast cancer, gastric cancer, and pancreatic cancer. Recently, the biological function of IL-17E (also called IL-25) in disease, particularly airway diseases, has attracted the attention of researchers. However, studies on IL-25 are scant. In this review, we detail the structural characteristics, expression patterns, responder cells, biological properties, and role of IL-25 in disease pathogenesis.http://dx.doi.org/10.1155/2018/6519465 |
| spellingShingle | Yuwan Liu Zewei Shao Guoqiang Shangguan Qingli Bie Bin Zhang Biological Properties and the Role of IL-25 in Disease Pathogenesis Journal of Immunology Research |
| title | Biological Properties and the Role of IL-25 in Disease Pathogenesis |
| title_full | Biological Properties and the Role of IL-25 in Disease Pathogenesis |
| title_fullStr | Biological Properties and the Role of IL-25 in Disease Pathogenesis |
| title_full_unstemmed | Biological Properties and the Role of IL-25 in Disease Pathogenesis |
| title_short | Biological Properties and the Role of IL-25 in Disease Pathogenesis |
| title_sort | biological properties and the role of il 25 in disease pathogenesis |
| url | http://dx.doi.org/10.1155/2018/6519465 |
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