A new Lactobacillus gasseri strain HMV18 inhibits the growth of pathogenic bacteria
To search for a new eco-friendly therapy for infectious disease caused by Escherichia coli, Staphylococcus aureus or Klebsiella oxytoca, we collected the vaginal swabs from healthy women, screened for Lactobacillus and found a strain repressing the growth of pathogenic bacteria. The new isolate was...
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| Format: | Article |
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Tsinghua University Press
2022-03-01
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| Series: | Food Science and Human Wellness |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213453021001063 |
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| author | Xiang Gao Zixuan Wang Xiang Li Xiaoling Zhang Shengqiang Du Miaomiao Jia Dailun Hu Xianxian Jia Bin Cong Yan Zhang Chunling Ma Song Zhou Jun Zhang |
| author_facet | Xiang Gao Zixuan Wang Xiang Li Xiaoling Zhang Shengqiang Du Miaomiao Jia Dailun Hu Xianxian Jia Bin Cong Yan Zhang Chunling Ma Song Zhou Jun Zhang |
| author_sort | Xiang Gao |
| collection | DOAJ |
| description | To search for a new eco-friendly therapy for infectious disease caused by Escherichia coli, Staphylococcus aureus or Klebsiella oxytoca, we collected the vaginal swabs from healthy women, screened for Lactobacillus and found a strain repressing the growth of pathogenic bacteria. The new isolate was identified as L. gasseri by the colony morphology, Gram staining, biochemical reactions and confirmed by the 16S rDNA sequencing. The HMV18 strain inhibited the growth of food-borne pathogens such as E. coli, S. aureus and K. oxytoca. The HMV18 strain was sensitive to penicillin, ampicillin, erythromycin, tetracycline and chloramphenicol. The HMV18 strain produced α-hemolysis. Pathological histology of the mice ileum showed that the mucosa, villi, lamina propria and crypt depth remained intact and there was no inflammation or hyperemia in the L. gasseri HMV18 gavaged group. L. gasseri HMV18 could not up-regulate inflammatory cytokines level of plasma. All the results suggested L. gasseri HMV18 is a candidate probiotic to be an additive for food preservation or drug to prevent food-borne diseases. |
| format | Article |
| id | doaj-art-cd70489297b2412fbf1aff55057daa33 |
| institution | Kabale University |
| issn | 2213-4530 |
| language | English |
| publishDate | 2022-03-01 |
| publisher | Tsinghua University Press |
| record_format | Article |
| series | Food Science and Human Wellness |
| spelling | doaj-art-cd70489297b2412fbf1aff55057daa332025-02-03T10:39:59ZengTsinghua University PressFood Science and Human Wellness2213-45302022-03-01112247254A new Lactobacillus gasseri strain HMV18 inhibits the growth of pathogenic bacteriaXiang Gao0Zixuan Wang1Xiang Li2Xiaoling Zhang3Shengqiang Du4Miaomiao Jia5Dailun Hu6Xianxian Jia7Bin Cong8Yan Zhang9Chunling Ma10Song Zhou11Jun Zhang12Department of Pathogen Biology, Institute of Basic Medicine, Hebei Medical University, Shijiazhuang 050017, China; Research Unit of Digestive Tract Microecosystem Pharmacology and Toxicology, Chinese Academy of Medical Sciences, Shijiazhuang 050017, ChinaDepartment of Pathogen Biology, Institute of Basic Medicine, Hebei Medical University, Shijiazhuang 050017, ChinaInstitute of Basic Medicine, Hebei Medical University, Shijiazhuang 050017, ChinaShijiazhuang Great Wall Integrated Traditional Chinese and Western Medicine Hospital, Shijiazhuang 050035, ChinaInstitute of Basic Medicine, Hebei Medical University, Shijiazhuang 050017, ChinaResearch Unit of Digestive Tract Microecosystem Pharmacology and Toxicology, Chinese Academy of Medical Sciences, Shijiazhuang 050017, China; Institute of Basic Medicine, Hebei Medical University, Shijiazhuang 050017, ChinaDepartment of Pathogen Biology, Institute of Basic Medicine, Hebei Medical University, Shijiazhuang 050017, ChinaDepartment of Pathogen Biology, Institute of Basic Medicine, Hebei Medical University, Shijiazhuang 050017, China; Research Unit of Digestive Tract Microecosystem Pharmacology and Toxicology, Chinese Academy of Medical Sciences, Shijiazhuang 050017, China; Corresponding authors.Research Unit of Digestive Tract Microecosystem Pharmacology and Toxicology, Chinese Academy of Medical Sciences, Shijiazhuang 050017, China; College of Forensic Medicine, Hebei Key Laboratory of Forensic Medicine, Collaborative Innovation Center of Forensic Medical Molecular Identification, Hebei Medical University, Shijiazhuang 050017, China; Corresponding authors.Research Unit of Digestive Tract Microecosystem Pharmacology and Toxicology, Chinese Academy of Medical Sciences, Shijiazhuang 050017, China; Hebei Food Safety Key Laboratory, Hebei Food Inspection and Research Institute, Shijiazhuang 050227, China; College of Forensic Medicine, Hebei Key Laboratory of Forensic Medicine, Collaborative Innovation Center of Forensic Medical Molecular Identification, Hebei Medical University, Shijiazhuang 050017, China; Corresponding authors.Research Unit of Digestive Tract Microecosystem Pharmacology and Toxicology, Chinese Academy of Medical Sciences, Shijiazhuang 050017, China; College of Forensic Medicine, Hebei Key Laboratory of Forensic Medicine, Collaborative Innovation Center of Forensic Medical Molecular Identification, Hebei Medical University, Shijiazhuang 050017, ChinaShijiazhuang Great Wall Integrated Traditional Chinese and Western Medicine Hospital, Shijiazhuang 050035, ChinaInstitute of Basic Medicine, Hebei Medical University, Shijiazhuang 050017, ChinaTo search for a new eco-friendly therapy for infectious disease caused by Escherichia coli, Staphylococcus aureus or Klebsiella oxytoca, we collected the vaginal swabs from healthy women, screened for Lactobacillus and found a strain repressing the growth of pathogenic bacteria. The new isolate was identified as L. gasseri by the colony morphology, Gram staining, biochemical reactions and confirmed by the 16S rDNA sequencing. The HMV18 strain inhibited the growth of food-borne pathogens such as E. coli, S. aureus and K. oxytoca. The HMV18 strain was sensitive to penicillin, ampicillin, erythromycin, tetracycline and chloramphenicol. The HMV18 strain produced α-hemolysis. Pathological histology of the mice ileum showed that the mucosa, villi, lamina propria and crypt depth remained intact and there was no inflammation or hyperemia in the L. gasseri HMV18 gavaged group. L. gasseri HMV18 could not up-regulate inflammatory cytokines level of plasma. All the results suggested L. gasseri HMV18 is a candidate probiotic to be an additive for food preservation or drug to prevent food-borne diseases.http://www.sciencedirect.com/science/article/pii/S2213453021001063ProbioticsLactobacillus gasseriAntagonismBacteriaSafety evaluation |
| spellingShingle | Xiang Gao Zixuan Wang Xiang Li Xiaoling Zhang Shengqiang Du Miaomiao Jia Dailun Hu Xianxian Jia Bin Cong Yan Zhang Chunling Ma Song Zhou Jun Zhang A new Lactobacillus gasseri strain HMV18 inhibits the growth of pathogenic bacteria Food Science and Human Wellness Probiotics Lactobacillus gasseri Antagonism Bacteria Safety evaluation |
| title | A new Lactobacillus gasseri strain HMV18 inhibits the growth of pathogenic bacteria |
| title_full | A new Lactobacillus gasseri strain HMV18 inhibits the growth of pathogenic bacteria |
| title_fullStr | A new Lactobacillus gasseri strain HMV18 inhibits the growth of pathogenic bacteria |
| title_full_unstemmed | A new Lactobacillus gasseri strain HMV18 inhibits the growth of pathogenic bacteria |
| title_short | A new Lactobacillus gasseri strain HMV18 inhibits the growth of pathogenic bacteria |
| title_sort | new lactobacillus gasseri strain hmv18 inhibits the growth of pathogenic bacteria |
| topic | Probiotics Lactobacillus gasseri Antagonism Bacteria Safety evaluation |
| url | http://www.sciencedirect.com/science/article/pii/S2213453021001063 |
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