Electrochemical Skin Conductance as a Marker of Painful Oxaliplatin-Induced Peripheral Neuropathy
Purpose. Oxaliplatin is a platinum compound widely used in gastrointestinal cancer treatment but produces dose-limiting peripheral neuropathy. New insights into oxaliplatin-induced peripheral neuropathy (OIPN) assessment are needed to detect more effectively this condition. In this context, we condu...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Neurology Research International |
| Online Access: | http://dx.doi.org/10.1155/2018/1254602 |
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| author | Jean-Baptiste Delmotte Abdulkarim Tutakhail Kahina Abdallah Pauline Reach Marguerite D’Ussel Gael Deplanque Hélène Beaussier François Coudoré |
| author_facet | Jean-Baptiste Delmotte Abdulkarim Tutakhail Kahina Abdallah Pauline Reach Marguerite D’Ussel Gael Deplanque Hélène Beaussier François Coudoré |
| author_sort | Jean-Baptiste Delmotte |
| collection | DOAJ |
| description | Purpose. Oxaliplatin is a platinum compound widely used in gastrointestinal cancer treatment but produces dose-limiting peripheral neuropathy. New insights into oxaliplatin-induced peripheral neuropathy (OIPN) assessment are needed to detect more effectively this condition. In this context, we conducted Canaloxa study, a prospective preliminary clinical trial that aimed to investigate how Electrochemical Skin Conductance (ESC), a parameter used in small fiber neuropathy assessment, could be helpful in OIPN diagnosis. Methods. Cancer patients treated for at least three months with oxaliplatin and suffering from clinically OIPN were included. Electrochemical Skin Conductance, thermal thresholds, and neuropathic pain were assessed in all included patients. Results. During one year, 36 patients were included. The main result was the correlation between ESC and Neuropathic Pain Symptom Inventory score for hands (rho value = -0.69, p < 0.0001) and feet (rho value = -0.79, p < 0.0001). ESC values were lower in neuropathic patients with painful symptoms than in ones without painful symptoms (p = 0.0003 and p < 0.0001 for hands and feet, respectively). No correlation was observed between ESC and thermal thresholds. Conclusion. These preliminary data suggest that ESC could be a useful objective marker of painful oxaliplatin-induced neuropathy and could complement the use of subjective clinical scales. This study was prospectively registered on clinicaltrials.gov (NCT02827916) before patient recruitment has begun. |
| format | Article |
| id | doaj-art-cd5e575e7ea74ef9876fc3929a788483 |
| institution | Kabale University |
| issn | 2090-1852 2090-1860 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neurology Research International |
| spelling | doaj-art-cd5e575e7ea74ef9876fc3929a7884832025-02-03T01:23:42ZengWileyNeurology Research International2090-18522090-18602018-01-01201810.1155/2018/12546021254602Electrochemical Skin Conductance as a Marker of Painful Oxaliplatin-Induced Peripheral NeuropathyJean-Baptiste Delmotte0Abdulkarim Tutakhail1Kahina Abdallah2Pauline Reach3Marguerite D’Ussel4Gael Deplanque5Hélène Beaussier6François Coudoré7Clinical Research Center, Paris Saint Joseph Hospital, Paris, F-75014, FranceCESP/UMR-S 1178, Univ. Paris-Sud, Fac. Pharmacie, INSERM, Université Paris-Saclay, Châtenay-Malabry, F-92290, FranceClinical Research Center, Paris Saint Joseph Hospital, Paris, F-75014, FranceNeurology Department, Paris Saint Joseph Hospital, Paris, F-75014, FrancePain Committee, Paris Saint Joseph Hospital, Paris, France, F-75014, FranceOncology Department, Paris Saint Joseph Hospital, Paris, F-75014, FranceClinical Research Center, Paris Saint Joseph Hospital, Paris, F-75014, FranceCESP/UMR-S 1178, Univ. Paris-Sud, Fac. Pharmacie, INSERM, Université Paris-Saclay, Châtenay-Malabry, F-92290, FrancePurpose. Oxaliplatin is a platinum compound widely used in gastrointestinal cancer treatment but produces dose-limiting peripheral neuropathy. New insights into oxaliplatin-induced peripheral neuropathy (OIPN) assessment are needed to detect more effectively this condition. In this context, we conducted Canaloxa study, a prospective preliminary clinical trial that aimed to investigate how Electrochemical Skin Conductance (ESC), a parameter used in small fiber neuropathy assessment, could be helpful in OIPN diagnosis. Methods. Cancer patients treated for at least three months with oxaliplatin and suffering from clinically OIPN were included. Electrochemical Skin Conductance, thermal thresholds, and neuropathic pain were assessed in all included patients. Results. During one year, 36 patients were included. The main result was the correlation between ESC and Neuropathic Pain Symptom Inventory score for hands (rho value = -0.69, p < 0.0001) and feet (rho value = -0.79, p < 0.0001). ESC values were lower in neuropathic patients with painful symptoms than in ones without painful symptoms (p = 0.0003 and p < 0.0001 for hands and feet, respectively). No correlation was observed between ESC and thermal thresholds. Conclusion. These preliminary data suggest that ESC could be a useful objective marker of painful oxaliplatin-induced neuropathy and could complement the use of subjective clinical scales. This study was prospectively registered on clinicaltrials.gov (NCT02827916) before patient recruitment has begun.http://dx.doi.org/10.1155/2018/1254602 |
| spellingShingle | Jean-Baptiste Delmotte Abdulkarim Tutakhail Kahina Abdallah Pauline Reach Marguerite D’Ussel Gael Deplanque Hélène Beaussier François Coudoré Electrochemical Skin Conductance as a Marker of Painful Oxaliplatin-Induced Peripheral Neuropathy Neurology Research International |
| title | Electrochemical Skin Conductance as a Marker of Painful Oxaliplatin-Induced Peripheral Neuropathy |
| title_full | Electrochemical Skin Conductance as a Marker of Painful Oxaliplatin-Induced Peripheral Neuropathy |
| title_fullStr | Electrochemical Skin Conductance as a Marker of Painful Oxaliplatin-Induced Peripheral Neuropathy |
| title_full_unstemmed | Electrochemical Skin Conductance as a Marker of Painful Oxaliplatin-Induced Peripheral Neuropathy |
| title_short | Electrochemical Skin Conductance as a Marker of Painful Oxaliplatin-Induced Peripheral Neuropathy |
| title_sort | electrochemical skin conductance as a marker of painful oxaliplatin induced peripheral neuropathy |
| url | http://dx.doi.org/10.1155/2018/1254602 |
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