Antimicrobial Peptides in Gastrointestinal Inflammation

Acute and chronic inflammations of mucosal surfaces are complex events in which the effector mechanisms of innate and adaptive immune systems interact with pathogenic and commensal bacteria. The role of constitutive and inducible antimicrobial peptides in intestinal inflammation has been investigate...

Full description

Saved in:
Bibliographic Details
Main Authors: Simon Jäger, Eduard F. Stange, Jan Wehkamp
Format: Article
Language:English
Published: Wiley 2010-01-01
Series:International Journal of Inflammation
Online Access:http://dx.doi.org/10.4061/2010/910283
Tags: Add Tag
No Tags, Be the first to tag this record!
_version_ 1832564637115088896
author Simon Jäger
Eduard F. Stange
Jan Wehkamp
author_facet Simon Jäger
Eduard F. Stange
Jan Wehkamp
author_sort Simon Jäger
collection DOAJ
description Acute and chronic inflammations of mucosal surfaces are complex events in which the effector mechanisms of innate and adaptive immune systems interact with pathogenic and commensal bacteria. The role of constitutive and inducible antimicrobial peptides in intestinal inflammation has been investigated thoroughly over the recent years, and their involvement in various disease states is expanded ever more. Especially in the intestines, a critical balance between luminal bacteria and the antimicrobial peptides is essential, and a breakdown in barrier function by impaired production of defensins is already implicated in Crohn's disease. In this paper, we focus on the role of antimicrobial peptides in inflammatory processes along the gastrointestinal tract, while considering the resident and pathogenic flora encountered at the specific sites. The role of antimicrobial peptides in the primary events of inflammatory bowel diseases receives special attention.
format Article
id doaj-art-cd565005943b4dea88393a6d058e471c
institution Kabale University
issn 2042-0099
language English
publishDate 2010-01-01
publisher Wiley
record_format Article
series International Journal of Inflammation
spelling doaj-art-cd565005943b4dea88393a6d058e471c2025-02-03T01:10:34ZengWileyInternational Journal of Inflammation2042-00992010-01-01201010.4061/2010/910283910283Antimicrobial Peptides in Gastrointestinal InflammationSimon Jäger0Eduard F. Stange1Jan Wehkamp2Department of Internal Medicine I, Robert Bosch Hospital, Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Auerbachstr. 112, 70376 Stuttgart, GermanyDepartment of Internal Medicine I, Robert Bosch Hospital, Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Auerbachstr. 112, 70376 Stuttgart, GermanyDepartment of Internal Medicine I, Robert Bosch Hospital, Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Auerbachstr. 112, 70376 Stuttgart, GermanyAcute and chronic inflammations of mucosal surfaces are complex events in which the effector mechanisms of innate and adaptive immune systems interact with pathogenic and commensal bacteria. The role of constitutive and inducible antimicrobial peptides in intestinal inflammation has been investigated thoroughly over the recent years, and their involvement in various disease states is expanded ever more. Especially in the intestines, a critical balance between luminal bacteria and the antimicrobial peptides is essential, and a breakdown in barrier function by impaired production of defensins is already implicated in Crohn's disease. In this paper, we focus on the role of antimicrobial peptides in inflammatory processes along the gastrointestinal tract, while considering the resident and pathogenic flora encountered at the specific sites. The role of antimicrobial peptides in the primary events of inflammatory bowel diseases receives special attention.http://dx.doi.org/10.4061/2010/910283
spellingShingle Simon Jäger
Eduard F. Stange
Jan Wehkamp
Antimicrobial Peptides in Gastrointestinal Inflammation
International Journal of Inflammation
title Antimicrobial Peptides in Gastrointestinal Inflammation
title_full Antimicrobial Peptides in Gastrointestinal Inflammation
title_fullStr Antimicrobial Peptides in Gastrointestinal Inflammation
title_full_unstemmed Antimicrobial Peptides in Gastrointestinal Inflammation
title_short Antimicrobial Peptides in Gastrointestinal Inflammation
title_sort antimicrobial peptides in gastrointestinal inflammation
url http://dx.doi.org/10.4061/2010/910283
work_keys_str_mv AT simonjager antimicrobialpeptidesingastrointestinalinflammation
AT eduardfstange antimicrobialpeptidesingastrointestinalinflammation
AT janwehkamp antimicrobialpeptidesingastrointestinalinflammation