Antimicrobial Peptides in Gastrointestinal Inflammation
Acute and chronic inflammations of mucosal surfaces are complex events in which the effector mechanisms of innate and adaptive immune systems interact with pathogenic and commensal bacteria. The role of constitutive and inducible antimicrobial peptides in intestinal inflammation has been investigate...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | International Journal of Inflammation |
| Online Access: | http://dx.doi.org/10.4061/2010/910283 |
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| _version_ | 1832564637115088896 |
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| author | Simon Jäger Eduard F. Stange Jan Wehkamp |
| author_facet | Simon Jäger Eduard F. Stange Jan Wehkamp |
| author_sort | Simon Jäger |
| collection | DOAJ |
| description | Acute and chronic inflammations of mucosal surfaces are complex events in which the effector mechanisms of innate and adaptive immune systems interact with pathogenic and commensal bacteria. The role of constitutive and inducible antimicrobial peptides in intestinal inflammation has been investigated thoroughly over the recent years, and their involvement in various disease states is expanded ever more. Especially in the intestines, a critical balance between luminal bacteria and the antimicrobial peptides is essential, and a breakdown in barrier function by impaired production of defensins is already implicated in Crohn's disease. In this paper, we focus on the role of antimicrobial peptides in inflammatory processes along the gastrointestinal tract, while considering the resident and pathogenic flora encountered at the specific sites. The role of antimicrobial peptides in the primary events of inflammatory bowel diseases receives special attention. |
| format | Article |
| id | doaj-art-cd565005943b4dea88393a6d058e471c |
| institution | Kabale University |
| issn | 2042-0099 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Inflammation |
| spelling | doaj-art-cd565005943b4dea88393a6d058e471c2025-02-03T01:10:34ZengWileyInternational Journal of Inflammation2042-00992010-01-01201010.4061/2010/910283910283Antimicrobial Peptides in Gastrointestinal InflammationSimon Jäger0Eduard F. Stange1Jan Wehkamp2Department of Internal Medicine I, Robert Bosch Hospital, Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Auerbachstr. 112, 70376 Stuttgart, GermanyDepartment of Internal Medicine I, Robert Bosch Hospital, Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Auerbachstr. 112, 70376 Stuttgart, GermanyDepartment of Internal Medicine I, Robert Bosch Hospital, Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Auerbachstr. 112, 70376 Stuttgart, GermanyAcute and chronic inflammations of mucosal surfaces are complex events in which the effector mechanisms of innate and adaptive immune systems interact with pathogenic and commensal bacteria. The role of constitutive and inducible antimicrobial peptides in intestinal inflammation has been investigated thoroughly over the recent years, and their involvement in various disease states is expanded ever more. Especially in the intestines, a critical balance between luminal bacteria and the antimicrobial peptides is essential, and a breakdown in barrier function by impaired production of defensins is already implicated in Crohn's disease. In this paper, we focus on the role of antimicrobial peptides in inflammatory processes along the gastrointestinal tract, while considering the resident and pathogenic flora encountered at the specific sites. The role of antimicrobial peptides in the primary events of inflammatory bowel diseases receives special attention.http://dx.doi.org/10.4061/2010/910283 |
| spellingShingle | Simon Jäger Eduard F. Stange Jan Wehkamp Antimicrobial Peptides in Gastrointestinal Inflammation International Journal of Inflammation |
| title | Antimicrobial Peptides in Gastrointestinal Inflammation |
| title_full | Antimicrobial Peptides in Gastrointestinal Inflammation |
| title_fullStr | Antimicrobial Peptides in Gastrointestinal Inflammation |
| title_full_unstemmed | Antimicrobial Peptides in Gastrointestinal Inflammation |
| title_short | Antimicrobial Peptides in Gastrointestinal Inflammation |
| title_sort | antimicrobial peptides in gastrointestinal inflammation |
| url | http://dx.doi.org/10.4061/2010/910283 |
| work_keys_str_mv | AT simonjager antimicrobialpeptidesingastrointestinalinflammation AT eduardfstange antimicrobialpeptidesingastrointestinalinflammation AT janwehkamp antimicrobialpeptidesingastrointestinalinflammation |