Improved Translational Relevance of In Vitro Fibrosis Models by Integrating IOX2-Mediated Hypoxia-Mimicking Pathways

Improved Translational Relevance of In Vitro Fibrosis Models by Integrating IOX2-Mediated Hypoxia-Mimicking Pathways

<b>Background/Objectives</b>: Preclinical models of liver fibrosis only partially mimic human disease processes. Particularly, traditional transforming growth factor beta 1 (TGFβ1)-induced hepatic stellate cell (HSC) models lack relevant processes, including hypoxia-induced pathways. Her...

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Bibliographic Details
Main Authors: Manuel A. González Hernández, Jennifer Venhorst, Lars Verschuren, Karin Toet, Martien P. M. Caspers, Martine C. Morrison, Beatrice Coornaert, Gerard J. P. van Westen, Roeland Hanemaaijer
Format: Article
Language:English
Published: MDPI AG 2025-06-01
Series:Biomedicines
Subjects:
liver fibrosis
preclinical models
fibrosis mechanisms
hypoxia
Online Access:https://www.mdpi.com/2227-9059/13/6/1448
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