Effect of Melatonin on Cognitive Function and Sleep in relation to Breast Cancer Surgery: A Randomized, Double-Blind, Placebo-Controlled Trial
Background. Sleep disturbances and cognitive dysfunction are common in patients with breast cancer. Disturbed sleep leads to poor cognitive performance and exogenous melatonin may improve sleep and attenuate cognitive dysfunction. We hypothesized that melatonin would improve sleep and cognitive func...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | International Journal of Breast Cancer |
| Online Access: | http://dx.doi.org/10.1155/2014/416531 |
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| _version_ | 1832549614348140544 |
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| author | Melissa Voigt Hansen Michael Tvilling Madsen Lærke Toftegård Andersen Ida Hageman Lars Simon Rasmussen Susanne Bokmand Jacob Rosenberg Ismail Gögenur |
| author_facet | Melissa Voigt Hansen Michael Tvilling Madsen Lærke Toftegård Andersen Ida Hageman Lars Simon Rasmussen Susanne Bokmand Jacob Rosenberg Ismail Gögenur |
| author_sort | Melissa Voigt Hansen |
| collection | DOAJ |
| description | Background. Sleep disturbances and cognitive dysfunction are common in patients with breast cancer. Disturbed sleep leads to poor cognitive performance and exogenous melatonin may improve sleep and attenuate cognitive dysfunction. We hypothesized that melatonin would improve sleep and cognitive function after surgery. Methods. This study reports secondary endpoints from a randomized, double-blind, placebo-controlled trial. Women, 30–75 years, were randomized to 6mg oral melatonin/placebo for 3 months. We assessed postoperative cognitive dysfunction (POCD) with a neuropsychological test battery, sleep with a diary, and sleep quality with VAS. Results. 54 patients were randomized to melatonin (n=28) or placebo (n=26); 11 withdrew (10 placebo, 1 melatonin, P=0.002). The incidence of POCD was 0% (0/20) [95% CI 0.0%; 16.8%] in the placebo group and 0% (0/26) [95% CI 0.0%; 13.2%] in the melatonin group 2 weeks postoperatively (P=1.00) and 6.3% (1/16) [95% CI 0.0%; 30.2%] in the placebo group and 0% (0/26) [95% CI 0.0%; 13.2%] in the melatonin group 12 weeks postoperatively (P=0.38). Sleep efficiency was significantly greater in the melatonin group; mean difference was 4.28% [95% CI 0.57; 7.82] (P=0.02). The total sleep period was significantly longer in the melatonin group; mean difference was 37.0 min [95% CI 3.6; 69.7] (P=0.03). Conclusion. Melatonin increased sleep efficiency and total sleep time but did not affect cognitive function. The dropout rate was significantly lower in the melatonin group. This trial is registered with Clinicaltrials.gov NCT01355523. |
| format | Article |
| id | doaj-art-cd429f2abba14bcdad17b1e9d1c3c675 |
| institution | Kabale University |
| issn | 2090-3170 2090-3189 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Breast Cancer |
| spelling | doaj-art-cd429f2abba14bcdad17b1e9d1c3c6752025-02-03T06:10:56ZengWileyInternational Journal of Breast Cancer2090-31702090-31892014-01-01201410.1155/2014/416531416531Effect of Melatonin on Cognitive Function and Sleep in relation to Breast Cancer Surgery: A Randomized, Double-Blind, Placebo-Controlled TrialMelissa Voigt Hansen0Michael Tvilling Madsen1Lærke Toftegård Andersen2Ida Hageman3Lars Simon Rasmussen4Susanne Bokmand5Jacob Rosenberg6Ismail Gögenur7Department of Surgery, Herlev Hospital, University of Copenhagen, 2730 Herlev, DenmarkDepartment of Surgery, Herlev Hospital, University of Copenhagen, 2730 Herlev, DenmarkDepartment of Surgery, Herlev Hospital, University of Copenhagen, 2730 Herlev, DenmarkPsychiatric Center Copenhagen, Rigshospitalet, University of Copenhagen, 2100 København Ø, DenmarkDepartment of Anaesthesia, Centre of Head and Orthopaedics, University of Copenhagen, 2100 København Ø, DenmarkDepartment of Breast Surgery, Herlev Hospital, University of Copenhagen, 2730 Herlev, DenmarkDepartment of Surgery, Herlev Hospital, University of Copenhagen, 2730 Herlev, DenmarkDepartment of Surgery, Herlev Hospital, University of Copenhagen, 2730 Herlev, DenmarkBackground. Sleep disturbances and cognitive dysfunction are common in patients with breast cancer. Disturbed sleep leads to poor cognitive performance and exogenous melatonin may improve sleep and attenuate cognitive dysfunction. We hypothesized that melatonin would improve sleep and cognitive function after surgery. Methods. This study reports secondary endpoints from a randomized, double-blind, placebo-controlled trial. Women, 30–75 years, were randomized to 6mg oral melatonin/placebo for 3 months. We assessed postoperative cognitive dysfunction (POCD) with a neuropsychological test battery, sleep with a diary, and sleep quality with VAS. Results. 54 patients were randomized to melatonin (n=28) or placebo (n=26); 11 withdrew (10 placebo, 1 melatonin, P=0.002). The incidence of POCD was 0% (0/20) [95% CI 0.0%; 16.8%] in the placebo group and 0% (0/26) [95% CI 0.0%; 13.2%] in the melatonin group 2 weeks postoperatively (P=1.00) and 6.3% (1/16) [95% CI 0.0%; 30.2%] in the placebo group and 0% (0/26) [95% CI 0.0%; 13.2%] in the melatonin group 12 weeks postoperatively (P=0.38). Sleep efficiency was significantly greater in the melatonin group; mean difference was 4.28% [95% CI 0.57; 7.82] (P=0.02). The total sleep period was significantly longer in the melatonin group; mean difference was 37.0 min [95% CI 3.6; 69.7] (P=0.03). Conclusion. Melatonin increased sleep efficiency and total sleep time but did not affect cognitive function. The dropout rate was significantly lower in the melatonin group. This trial is registered with Clinicaltrials.gov NCT01355523.http://dx.doi.org/10.1155/2014/416531 |
| spellingShingle | Melissa Voigt Hansen Michael Tvilling Madsen Lærke Toftegård Andersen Ida Hageman Lars Simon Rasmussen Susanne Bokmand Jacob Rosenberg Ismail Gögenur Effect of Melatonin on Cognitive Function and Sleep in relation to Breast Cancer Surgery: A Randomized, Double-Blind, Placebo-Controlled Trial International Journal of Breast Cancer |
| title | Effect of Melatonin on Cognitive Function and Sleep in relation to Breast Cancer Surgery: A Randomized, Double-Blind, Placebo-Controlled Trial |
| title_full | Effect of Melatonin on Cognitive Function and Sleep in relation to Breast Cancer Surgery: A Randomized, Double-Blind, Placebo-Controlled Trial |
| title_fullStr | Effect of Melatonin on Cognitive Function and Sleep in relation to Breast Cancer Surgery: A Randomized, Double-Blind, Placebo-Controlled Trial |
| title_full_unstemmed | Effect of Melatonin on Cognitive Function and Sleep in relation to Breast Cancer Surgery: A Randomized, Double-Blind, Placebo-Controlled Trial |
| title_short | Effect of Melatonin on Cognitive Function and Sleep in relation to Breast Cancer Surgery: A Randomized, Double-Blind, Placebo-Controlled Trial |
| title_sort | effect of melatonin on cognitive function and sleep in relation to breast cancer surgery a randomized double blind placebo controlled trial |
| url | http://dx.doi.org/10.1155/2014/416531 |
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