A Pregnancy Case of Primary Mediastinal Large B Cell Lymphoma with Superior Vena Cava Syndrome
Primary mediastinal large B cell lymphoma (PMLBCL) is a subtype of non-Hodgkin’s lymphoma which presents rarely in pregnancy. It is an aggressive tumour that is associated with symptoms of superior vena cava (SVC) compression and airway compromise such as dyspnoea, facial and arm swelling, cough, or...
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Case Reports in Obstetrics and Gynecology |
| Online Access: | http://dx.doi.org/10.1155/2021/3438230 |
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| author | Lauren Brownhalls Ann Gillett Yasmin Whately Keisuke Tanaka |
| author_facet | Lauren Brownhalls Ann Gillett Yasmin Whately Keisuke Tanaka |
| author_sort | Lauren Brownhalls |
| collection | DOAJ |
| description | Primary mediastinal large B cell lymphoma (PMLBCL) is a subtype of non-Hodgkin’s lymphoma which presents rarely in pregnancy. It is an aggressive tumour that is associated with symptoms of superior vena cava (SVC) compression and airway compromise such as dyspnoea, facial and arm swelling, cough, or chest pain. Timely diagnosis is imperative to optimising patient outcomes and reducing both maternal and fetal morbidity and mortality. We report a case of a 33-year-old woman diagnosed with PMLBCL who presented at 33-week gestation with SVC obstruction to 1 mm in diameter. After multidisciplinary team discussion regarding maternal and fetal implications of management options, we proceeded to a caesarean section and initiated chemotherapy postdelivery. Lower segment caesarean section was uncomplicated, and she underwent a cycle of R-CHOEP followed by 5 cycles of DA-EPOCH. Eighteen months since the completion of the chemotherapy, the disease remained in remission. |
| format | Article |
| id | doaj-art-cd3faa3f8cc74bf195b51c23e5f43981 |
| institution | Kabale University |
| issn | 2090-6692 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Obstetrics and Gynecology |
| spelling | doaj-art-cd3faa3f8cc74bf195b51c23e5f439812025-02-03T05:59:58ZengWileyCase Reports in Obstetrics and Gynecology2090-66922021-01-01202110.1155/2021/3438230A Pregnancy Case of Primary Mediastinal Large B Cell Lymphoma with Superior Vena Cava SyndromeLauren Brownhalls0Ann Gillett1Yasmin Whately2Keisuke Tanaka3Women’s and Newborn ServicesDepartment of HematologyDepartment of AnaesthesiaWomen’s and Newborn ServicesPrimary mediastinal large B cell lymphoma (PMLBCL) is a subtype of non-Hodgkin’s lymphoma which presents rarely in pregnancy. It is an aggressive tumour that is associated with symptoms of superior vena cava (SVC) compression and airway compromise such as dyspnoea, facial and arm swelling, cough, or chest pain. Timely diagnosis is imperative to optimising patient outcomes and reducing both maternal and fetal morbidity and mortality. We report a case of a 33-year-old woman diagnosed with PMLBCL who presented at 33-week gestation with SVC obstruction to 1 mm in diameter. After multidisciplinary team discussion regarding maternal and fetal implications of management options, we proceeded to a caesarean section and initiated chemotherapy postdelivery. Lower segment caesarean section was uncomplicated, and she underwent a cycle of R-CHOEP followed by 5 cycles of DA-EPOCH. Eighteen months since the completion of the chemotherapy, the disease remained in remission.http://dx.doi.org/10.1155/2021/3438230 |
| spellingShingle | Lauren Brownhalls Ann Gillett Yasmin Whately Keisuke Tanaka A Pregnancy Case of Primary Mediastinal Large B Cell Lymphoma with Superior Vena Cava Syndrome Case Reports in Obstetrics and Gynecology |
| title | A Pregnancy Case of Primary Mediastinal Large B Cell Lymphoma with Superior Vena Cava Syndrome |
| title_full | A Pregnancy Case of Primary Mediastinal Large B Cell Lymphoma with Superior Vena Cava Syndrome |
| title_fullStr | A Pregnancy Case of Primary Mediastinal Large B Cell Lymphoma with Superior Vena Cava Syndrome |
| title_full_unstemmed | A Pregnancy Case of Primary Mediastinal Large B Cell Lymphoma with Superior Vena Cava Syndrome |
| title_short | A Pregnancy Case of Primary Mediastinal Large B Cell Lymphoma with Superior Vena Cava Syndrome |
| title_sort | pregnancy case of primary mediastinal large b cell lymphoma with superior vena cava syndrome |
| url | http://dx.doi.org/10.1155/2021/3438230 |
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