Clara Cell Protein Expression in Mechanically Ventilated Term and Preterm Infants with Respiratory Distress Syndrome and at Risk of Bronchopulmonary Dysplasia: A Pilot Study
The aim of this pilot study was to determine Clara cell protein (CC16) concentration in bronchoalveolar lavages (BAL) fluid from full-term and preterm (<37 weeks’ gestational age) neonates requiring respiratory support, having symptoms of neonatal respiratory distress syndrome, and at risk of bro...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Canadian Respiratory Journal |
| Online Access: | http://dx.doi.org/10.1155/2017/8074678 |
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| author | José Guzmán-Bárcenas Antonio Calderón-Moore Héctor Baptista-González Claudine Irles |
| author_facet | José Guzmán-Bárcenas Antonio Calderón-Moore Héctor Baptista-González Claudine Irles |
| author_sort | José Guzmán-Bárcenas |
| collection | DOAJ |
| description | The aim of this pilot study was to determine Clara cell protein (CC16) concentration in bronchoalveolar lavages (BAL) fluid from full-term and preterm (<37 weeks’ gestational age) neonates requiring respiratory support, having symptoms of neonatal respiratory distress syndrome, and at risk of bronchopulmonary dysplasia (BPD). We hypothesized that CC16 may be predictive of BPD diagnosis regardless of gestational age. BAL fluid CC16 was measured by ELISA at birth and at day 7 of life. Both groups that developed BPD showed significantly decreased BAL fluid CC16 levels compared to those infants that did not develop the disease. CC16 positively correlated with diagnosis of BPD and negatively with the severity of the disease. These results suggest that BAL fluid CC16 levels may have a diagnostic value at day 7 for BPD in both term and preterm infants. This study demonstrates the potential utility of BAL fluid CC16 levels as a biomarker for BPD in term infants. |
| format | Article |
| id | doaj-art-cd3c280bea28410690b957992ac5b732 |
| institution | Kabale University |
| issn | 1198-2241 1916-7245 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Respiratory Journal |
| spelling | doaj-art-cd3c280bea28410690b957992ac5b7322025-02-03T06:45:58ZengWileyCanadian Respiratory Journal1198-22411916-72452017-01-01201710.1155/2017/80746788074678Clara Cell Protein Expression in Mechanically Ventilated Term and Preterm Infants with Respiratory Distress Syndrome and at Risk of Bronchopulmonary Dysplasia: A Pilot StudyJosé Guzmán-Bárcenas0Antonio Calderón-Moore1Héctor Baptista-González2Claudine Irles3Department of Perinatal Hematology, Instituto Nacional de Perinatología Isidro Espinoza de los Reyes, Montes Urales 800, 11000 Lomas de Virreyes, CDMX, MexicoNeonatal Intensive Care Unit, Hospital Infantil de México, Dr. Márquez No. 162, Cuauhtémoc, 06720 Doctores, CDMX, MexicoDepartment of Perinatal Hematology, Instituto Nacional de Perinatología Isidro Espinoza de los Reyes, Montes Urales 800, 11000 Lomas de Virreyes, CDMX, MexicoDepartment of Physiology and Cellular Development, Instituto Nacional de Perinatología Isidro Espinoza de los Reyes, Montes Urales 800, 11000 Lomas de Virreyes, CDMX, MexicoThe aim of this pilot study was to determine Clara cell protein (CC16) concentration in bronchoalveolar lavages (BAL) fluid from full-term and preterm (<37 weeks’ gestational age) neonates requiring respiratory support, having symptoms of neonatal respiratory distress syndrome, and at risk of bronchopulmonary dysplasia (BPD). We hypothesized that CC16 may be predictive of BPD diagnosis regardless of gestational age. BAL fluid CC16 was measured by ELISA at birth and at day 7 of life. Both groups that developed BPD showed significantly decreased BAL fluid CC16 levels compared to those infants that did not develop the disease. CC16 positively correlated with diagnosis of BPD and negatively with the severity of the disease. These results suggest that BAL fluid CC16 levels may have a diagnostic value at day 7 for BPD in both term and preterm infants. This study demonstrates the potential utility of BAL fluid CC16 levels as a biomarker for BPD in term infants.http://dx.doi.org/10.1155/2017/8074678 |
| spellingShingle | José Guzmán-Bárcenas Antonio Calderón-Moore Héctor Baptista-González Claudine Irles Clara Cell Protein Expression in Mechanically Ventilated Term and Preterm Infants with Respiratory Distress Syndrome and at Risk of Bronchopulmonary Dysplasia: A Pilot Study Canadian Respiratory Journal |
| title | Clara Cell Protein Expression in Mechanically Ventilated Term and Preterm Infants with Respiratory Distress Syndrome and at Risk of Bronchopulmonary Dysplasia: A Pilot Study |
| title_full | Clara Cell Protein Expression in Mechanically Ventilated Term and Preterm Infants with Respiratory Distress Syndrome and at Risk of Bronchopulmonary Dysplasia: A Pilot Study |
| title_fullStr | Clara Cell Protein Expression in Mechanically Ventilated Term and Preterm Infants with Respiratory Distress Syndrome and at Risk of Bronchopulmonary Dysplasia: A Pilot Study |
| title_full_unstemmed | Clara Cell Protein Expression in Mechanically Ventilated Term and Preterm Infants with Respiratory Distress Syndrome and at Risk of Bronchopulmonary Dysplasia: A Pilot Study |
| title_short | Clara Cell Protein Expression in Mechanically Ventilated Term and Preterm Infants with Respiratory Distress Syndrome and at Risk of Bronchopulmonary Dysplasia: A Pilot Study |
| title_sort | clara cell protein expression in mechanically ventilated term and preterm infants with respiratory distress syndrome and at risk of bronchopulmonary dysplasia a pilot study |
| url | http://dx.doi.org/10.1155/2017/8074678 |
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