Soluble RAGE Plasma Levels in Patients with Coronary Artery Disease and Peripheral Artery Disease
The objective of the present study was define in a relatively large patient population with coronary artery disease (CAD) whether the concomitant presence of peripheral artery disease (PAD), which is known to convey additional cardiovascular risk, was associated with different circulating levels of...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1155/2013/584504 |
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| author | Colomba Falcone Sara Bozzini Luigina Guasti Angela D’Angelo Anna Clizia Capettini Edoardo Maria Paganini Rossana Falcone Roberto Moia Carmine Gazzaruso Gabriele Pelissero |
| author_facet | Colomba Falcone Sara Bozzini Luigina Guasti Angela D’Angelo Anna Clizia Capettini Edoardo Maria Paganini Rossana Falcone Roberto Moia Carmine Gazzaruso Gabriele Pelissero |
| author_sort | Colomba Falcone |
| collection | DOAJ |
| description | The objective of the present study was define in a relatively large patient population with coronary artery disease (CAD) whether the concomitant presence of peripheral artery disease (PAD), which is known to convey additional cardiovascular risk, was associated with different circulating levels of sRAGE with respect to CAD alone and control subjects. Clinical and laboratory parameters including the ankle brachial index (ABI) and sRAGE (enzyme-linked immunosorbent assay kit) were investigated in 544 patients with angiographically documented CAD and 328 control subjects. 213/554 CAD patients (39%) showed an ABI <0.9 associated with typical symptoms (group CAD + PAD), whereas 331 patients were free from PAD. The concentration of plasma sRAGE was significantly lower (P<0.0001) in CAD population, with and without PAD, than in control subjects. Among CAD patients, those with PAD showed lower levels of sRAGE. The distribution of the three groups (CAD, CAD + PAD, and controls) according to sRAGE tertiles showed that lower levels were more frequent in patients with CAD and CAD + PAD, whereas higher levels were more frequently found in controls. CAD patients presenting with PAD have lower sRAGE levels than CAD patients without peripheral atherosclerosis showing that stable atherosclerotic lesions in different vascular districts are inversely related to soluble decoy receptor sRAGE. |
| format | Article |
| id | doaj-art-cd36e8a060f0449aa78c5a0d1b470e26 |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-cd36e8a060f0449aa78c5a0d1b470e262025-02-03T01:25:32ZengWileyThe Scientific World Journal1537-744X2013-01-01201310.1155/2013/584504584504Soluble RAGE Plasma Levels in Patients with Coronary Artery Disease and Peripheral Artery DiseaseColomba Falcone0Sara Bozzini1Luigina Guasti2Angela D’Angelo3Anna Clizia Capettini4Edoardo Maria Paganini5Rossana Falcone6Roberto Moia7Carmine Gazzaruso8Gabriele Pelissero9Interdepartmental Center of Research in Molecular Medicine (CIRMC), University of Pavia, 27100 Pavia, ItalyInterdepartmental Center of Research in Molecular Medicine (CIRMC), University of Pavia, 27100 Pavia, ItalyDepartment of Clinical and Experimental Medicine, University of Insubria, 21100 Varese, ItalyDepartment of Internal Medicine, IRCCS Policlinico San Matteo, 27100 Pavia, ItalyInterdepartmental Center of Research in Molecular Medicine (CIRMC), University of Pavia, 27100 Pavia, ItalyDepartment of Cardiology, “Istituti Clinici di Pavia e Vigevano” University Hospital, 27100 Pavia, ItalyInterdepartmental Center of Research in Molecular Medicine (CIRMC), University of Pavia, 27100 Pavia, ItalyInterdepartmental Center of Research in Molecular Medicine (CIRMC), University of Pavia, 27100 Pavia, ItalyInterdepartmental Center of Research in Molecular Medicine (CIRMC), University of Pavia, 27100 Pavia, ItalyDepartment of Cardiology, “Istituti Clinici di Pavia e Vigevano” University Hospital, 27100 Pavia, ItalyThe objective of the present study was define in a relatively large patient population with coronary artery disease (CAD) whether the concomitant presence of peripheral artery disease (PAD), which is known to convey additional cardiovascular risk, was associated with different circulating levels of sRAGE with respect to CAD alone and control subjects. Clinical and laboratory parameters including the ankle brachial index (ABI) and sRAGE (enzyme-linked immunosorbent assay kit) were investigated in 544 patients with angiographically documented CAD and 328 control subjects. 213/554 CAD patients (39%) showed an ABI <0.9 associated with typical symptoms (group CAD + PAD), whereas 331 patients were free from PAD. The concentration of plasma sRAGE was significantly lower (P<0.0001) in CAD population, with and without PAD, than in control subjects. Among CAD patients, those with PAD showed lower levels of sRAGE. The distribution of the three groups (CAD, CAD + PAD, and controls) according to sRAGE tertiles showed that lower levels were more frequent in patients with CAD and CAD + PAD, whereas higher levels were more frequently found in controls. CAD patients presenting with PAD have lower sRAGE levels than CAD patients without peripheral atherosclerosis showing that stable atherosclerotic lesions in different vascular districts are inversely related to soluble decoy receptor sRAGE.http://dx.doi.org/10.1155/2013/584504 |
| spellingShingle | Colomba Falcone Sara Bozzini Luigina Guasti Angela D’Angelo Anna Clizia Capettini Edoardo Maria Paganini Rossana Falcone Roberto Moia Carmine Gazzaruso Gabriele Pelissero Soluble RAGE Plasma Levels in Patients with Coronary Artery Disease and Peripheral Artery Disease The Scientific World Journal |
| title | Soluble RAGE Plasma Levels in Patients with Coronary Artery Disease and Peripheral Artery Disease |
| title_full | Soluble RAGE Plasma Levels in Patients with Coronary Artery Disease and Peripheral Artery Disease |
| title_fullStr | Soluble RAGE Plasma Levels in Patients with Coronary Artery Disease and Peripheral Artery Disease |
| title_full_unstemmed | Soluble RAGE Plasma Levels in Patients with Coronary Artery Disease and Peripheral Artery Disease |
| title_short | Soluble RAGE Plasma Levels in Patients with Coronary Artery Disease and Peripheral Artery Disease |
| title_sort | soluble rage plasma levels in patients with coronary artery disease and peripheral artery disease |
| url | http://dx.doi.org/10.1155/2013/584504 |
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