Interaction effect between vitamin D and gestational diabetes mellitus in the second trimester
ObjectiveTo investigate the relationship between serum 25(OH)D and gestational diabetes mellitus in the second trimester (GDM), to analyze the interaction effect of key risk factors, so as to provide a basis for clinical personalized vitamin D supplementation.MethodsA total of 266 pregnant women who...
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Shanghai Preventive Medicine Association
2024-11-01
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| Series: | Shanghai yufang yixue |
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| Online Access: | http://www.sjpm.org.cn/article/doi/10.19428/j.cnki.sjpm.2024.24041?viewType=HTML |
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| author | MA Ziwen DING Xiaoying CHU Liming ZHANG Yan ZHANG Aifeng ZHU Yanjun WANG Xun XIE Zhenyu |
| author_facet | MA Ziwen DING Xiaoying CHU Liming ZHANG Yan ZHANG Aifeng ZHU Yanjun WANG Xun XIE Zhenyu |
| author_sort | MA Ziwen |
| collection | DOAJ |
| description | ObjectiveTo investigate the relationship between serum 25(OH)D and gestational diabetes mellitus in the second trimester (GDM), to analyze the interaction effect of key risk factors, so as to provide a basis for clinical personalized vitamin D supplementation.MethodsA total of 266 pregnant women who registered and took regular obstetric check-ups in Shanghai Pudong New Area Health Care Hospital for Women and Children from June to December 2022, were selected as the research subjects. According to the results of oral glucose tolerance test (OGTT), the subjects were divided into the GDM group (131) and control group (135). The level of serum 25(OH)D at the time of OGTT were detected and other clinical indicators were followed up.ResultsThe age, systolic blood pressure in early pregnancy, pre-pregnancy BMI, FPG, OGTT 1-hour and 2-hour glucose, GHb, HOMA-IR, TG, AST, Cr, D-D, FDP and SF at 35 weeks’ gestation of the pregnant women were higher in the GDM group than that of the pregnant women in the normal group, while gestational weight gain and serum 25(OH)D level were significantly lower than that of the pregnant women in the normal group. Serum 25(OH)D was negatively correlated with HOMA-IR and WBS’s, but positively correlated with TG and ALT. Serum 25(OH)D was non-linearly correlated with the risk of GDM in an inverted J-shape, and there was an interaction effect of advanced age, pre-pregnancy obesity and vitamin D deficiency on the risk of GDM.ConclusionVitamin D is non-linearly associated with the risk of GDM. The risk of GDM is significantly reduced when serum 25(OH)D level ≥30 ng∙mL-1. |
| format | Article |
| id | doaj-art-cd31c4dec5de4587b3f2ccc893df1fa0 |
| institution | Kabale University |
| issn | 1004-9231 |
| language | zho |
| publishDate | 2024-11-01 |
| publisher | Shanghai Preventive Medicine Association |
| record_format | Article |
| series | Shanghai yufang yixue |
| spelling | doaj-art-cd31c4dec5de4587b3f2ccc893df1fa02025-01-23T23:27:10ZzhoShanghai Preventive Medicine AssociationShanghai yufang yixue1004-92312024-11-0136111094109910.19428/j.cnki.sjpm.2024.240411004-9231(2024)11-1094-06Interaction effect between vitamin D and gestational diabetes mellitus in the second trimesterMA Ziwen0DING Xiaoying1CHU Liming2ZHANG Yan3ZHANG Aifeng4ZHU Yanjun5WANG Xun6XIE Zhenyu7Shanghai Pudong New Area Health Care Hospital for Women and Children, Shanghai201206, ChinaShanghai Pudong New Area Health Care Hospital for Women and Children, Shanghai201206, ChinaShanghai Pudong New Area Health Care Hospital for Women and Children, Shanghai201206, ChinaShanghai Pudong New Area Health Care Hospital for Women and Children, Shanghai201206, ChinaShanghai Pudong New Area Health Care Hospital for Women and Children, Shanghai201206, ChinaShanghai Pudong New Area Health Care Hospital for Women and Children, Shanghai201206, ChinaShanghai Pudong New Area Health Care Hospital for Women and Children, Shanghai201206, ChinaShanghai Pudong New Area Health Care Hospital for Women and Children, Shanghai201206, ChinaObjectiveTo investigate the relationship between serum 25(OH)D and gestational diabetes mellitus in the second trimester (GDM), to analyze the interaction effect of key risk factors, so as to provide a basis for clinical personalized vitamin D supplementation.MethodsA total of 266 pregnant women who registered and took regular obstetric check-ups in Shanghai Pudong New Area Health Care Hospital for Women and Children from June to December 2022, were selected as the research subjects. According to the results of oral glucose tolerance test (OGTT), the subjects were divided into the GDM group (131) and control group (135). The level of serum 25(OH)D at the time of OGTT were detected and other clinical indicators were followed up.ResultsThe age, systolic blood pressure in early pregnancy, pre-pregnancy BMI, FPG, OGTT 1-hour and 2-hour glucose, GHb, HOMA-IR, TG, AST, Cr, D-D, FDP and SF at 35 weeks’ gestation of the pregnant women were higher in the GDM group than that of the pregnant women in the normal group, while gestational weight gain and serum 25(OH)D level were significantly lower than that of the pregnant women in the normal group. Serum 25(OH)D was negatively correlated with HOMA-IR and WBS’s, but positively correlated with TG and ALT. Serum 25(OH)D was non-linearly correlated with the risk of GDM in an inverted J-shape, and there was an interaction effect of advanced age, pre-pregnancy obesity and vitamin D deficiency on the risk of GDM.ConclusionVitamin D is non-linearly associated with the risk of GDM. The risk of GDM is significantly reduced when serum 25(OH)D level ≥30 ng∙mL-1.http://www.sjpm.org.cn/article/doi/10.19428/j.cnki.sjpm.2024.24041?viewType=HTMLserum 25(oh)dpre-pregnancy body mass indexadvanced agegestational diabetes mellitusinteraction |
| spellingShingle | MA Ziwen DING Xiaoying CHU Liming ZHANG Yan ZHANG Aifeng ZHU Yanjun WANG Xun XIE Zhenyu Interaction effect between vitamin D and gestational diabetes mellitus in the second trimester Shanghai yufang yixue serum 25(oh)d pre-pregnancy body mass index advanced age gestational diabetes mellitus interaction |
| title | Interaction effect between vitamin D and gestational diabetes mellitus in the second trimester |
| title_full | Interaction effect between vitamin D and gestational diabetes mellitus in the second trimester |
| title_fullStr | Interaction effect between vitamin D and gestational diabetes mellitus in the second trimester |
| title_full_unstemmed | Interaction effect between vitamin D and gestational diabetes mellitus in the second trimester |
| title_short | Interaction effect between vitamin D and gestational diabetes mellitus in the second trimester |
| title_sort | interaction effect between vitamin d and gestational diabetes mellitus in the second trimester |
| topic | serum 25(oh)d pre-pregnancy body mass index advanced age gestational diabetes mellitus interaction |
| url | http://www.sjpm.org.cn/article/doi/10.19428/j.cnki.sjpm.2024.24041?viewType=HTML |
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