Taxifolin attenuates liver fibrosis by regulating the phosphorylation of NDRG1 at Thr328 via hepatocyte-stellate cell cross talk

Taxifolin attenuates liver fibrosis by regulating the phosphorylation of NDRG1 at Thr328 via hepatocyte-stellate cell cross talk

Taxifolin (TAX) is a natural compound known for its liver protection effect, but the mechanism remains unknown. Phosphorylated proteomics analyses discovered that the phosphorylation level of NDRG1 at T328 was a key event of TAX-improved liver fibrosis. We established models with NDRG1 knockout (KO)...

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Bibliographic Details
Main Authors: Chuan Ding, Zeping Wang, Kao Shi, Sunan Li, Xinyue Dou, Yan Ning, Gang Cheng, Qiao Yang, Xianan Sang, Mengyun Peng, Qiang Lyu, Lu Wang, Xin Han, Gang Cao
Format: Article
Language:English
Published: Elsevier 2025-04-01
Series:Acta Pharmaceutica Sinica B
Subjects:
Taxifolin
Liver fibrosis
pNDRG1T328
Hepatocyte
Liver injury
HSCs
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383525000905
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