Estimation of SLE Activity Based on the Serum Level of Chosen Cytokines and Superoxide Radical Generation
We estimated the serum levels of IL-6, TNF-α and IL10, and generation of superoxide radicals, as well as their mutual dependence, in 63 SLE patients at various stages of disease activity. Our results indicate a statistically significant increase of the serum levels studied, and an increase of supero...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
1999-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1080/09629359990586 |
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| _version_ | 1832552740746690560 |
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| author | Elzbieta Waszczykowska Ewa Robak Anna Wozniacka Joanna Narbutt Jolanta Dorota Torzecka Anna Sysa-Jedrzejowska |
| author_facet | Elzbieta Waszczykowska Ewa Robak Anna Wozniacka Joanna Narbutt Jolanta Dorota Torzecka Anna Sysa-Jedrzejowska |
| author_sort | Elzbieta Waszczykowska |
| collection | DOAJ |
| description | We estimated the serum levels of IL-6, TNF-α and IL10, and generation of superoxide radicals, as well as their mutual dependence, in 63 SLE patients at various stages of disease activity. Our results indicate a statistically significant increase of the serum levels studied, and an increase of superoxide anion generation by granulocytes, in correlation with SLE activity. These results indicate that oxygen metabolism and the examined cytokines play an important role in pathogenesis of SLE. The assessment of these parameters can be useful in the estimation of disease activity. |
| format | Article |
| id | doaj-art-cd20ae7d917d43238e1f1dc79a40cebf |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 1999-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-cd20ae7d917d43238e1f1dc79a40cebf2025-02-03T05:58:05ZengWileyMediators of Inflammation0962-93511466-18611999-01-01829310010.1080/09629359990586Estimation of SLE Activity Based on the Serum Level of Chosen Cytokines and Superoxide Radical GenerationElzbieta Waszczykowska0Ewa Robak1Anna Wozniacka2Joanna Narbutt3Jolanta Dorota Torzecka4Anna Sysa-Jedrzejowska5Department of Dermatology and Venereology, Medical University of Lodz, Krzemieniecka 5, Lodz 94–017, PolandDepartment of Dermatology and Venereology, Medical University of Lodz, Krzemieniecka 5, Lodz 94–017, PolandDepartment of Dermatology and Venereology, Medical University of Lodz, Krzemieniecka 5, Lodz 94–017, PolandDepartment of Dermatology and Venereology, Medical University of Lodz, Krzemieniecka 5, Lodz 94–017, PolandDepartment of Dermatology and Venereology, Medical University of Lodz, Krzemieniecka 5, Lodz 94–017, PolandDepartment of Dermatology and Venereology, Medical University of Lodz, Krzemieniecka 5, Lodz 94–017, PolandWe estimated the serum levels of IL-6, TNF-α and IL10, and generation of superoxide radicals, as well as their mutual dependence, in 63 SLE patients at various stages of disease activity. Our results indicate a statistically significant increase of the serum levels studied, and an increase of superoxide anion generation by granulocytes, in correlation with SLE activity. These results indicate that oxygen metabolism and the examined cytokines play an important role in pathogenesis of SLE. The assessment of these parameters can be useful in the estimation of disease activity.http://dx.doi.org/10.1080/09629359990586 |
| spellingShingle | Elzbieta Waszczykowska Ewa Robak Anna Wozniacka Joanna Narbutt Jolanta Dorota Torzecka Anna Sysa-Jedrzejowska Estimation of SLE Activity Based on the Serum Level of Chosen Cytokines and Superoxide Radical Generation Mediators of Inflammation |
| title | Estimation of SLE Activity Based on the Serum Level of Chosen Cytokines and Superoxide Radical Generation |
| title_full | Estimation of SLE Activity Based on the Serum Level of Chosen Cytokines and Superoxide Radical Generation |
| title_fullStr | Estimation of SLE Activity Based on the Serum Level of Chosen Cytokines and Superoxide Radical Generation |
| title_full_unstemmed | Estimation of SLE Activity Based on the Serum Level of Chosen Cytokines and Superoxide Radical Generation |
| title_short | Estimation of SLE Activity Based on the Serum Level of Chosen Cytokines and Superoxide Radical Generation |
| title_sort | estimation of sle activity based on the serum level of chosen cytokines and superoxide radical generation |
| url | http://dx.doi.org/10.1080/09629359990586 |
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