Neuropeptidomics: Mass Spectrometry-Based Identification and Quantitation of Neuropeptides
Neuropeptides produced from prohormones by selective action of endopeptidases are vital signaling molecules, playing a critical role in a variety of physiological processes, such as addiction, depression, pain, and circadian rhythms. Neuropeptides bind to post-synaptic receptors and elicit cellular...
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BioMed Central
2016-03-01
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| Series: | Genomics & Informatics |
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| Online Access: | http://genominfo.org/upload/pdf/gni-14-12.pdf |
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| author | Ji Eun Lee |
| author_facet | Ji Eun Lee |
| author_sort | Ji Eun Lee |
| collection | DOAJ |
| description | Neuropeptides produced from prohormones by selective action of endopeptidases are vital signaling molecules, playing a critical role in a variety of physiological processes, such as addiction, depression, pain, and circadian rhythms. Neuropeptides bind to post-synaptic receptors and elicit cellular effects like classical neurotransmitters. While each neuropeptide could have its own biological function, mass spectrometry (MS) allows for the identification of the precise molecular forms of each peptide without a priori knowledge of the peptide identity and for the quantitation of neuropeptides in different conditions of the samples. MS-based neuropeptidomics approaches have been applied to various animal models and conditions to characterize and quantify novel neuropeptides, as well as known neuropeptides, advancing our understanding of nervous system function over the past decade. Here, we will present an overview of neuropeptides and MS-based neuropeptidomic strategies for the identification and quantitation of neuropeptides. |
| format | Article |
| id | doaj-art-cd2012c60e4149aaaec41582131a5a47 |
| institution | Kabale University |
| issn | 1598-866X 2234-0742 |
| language | English |
| publishDate | 2016-03-01 |
| publisher | BioMed Central |
| record_format | Article |
| series | Genomics & Informatics |
| spelling | doaj-art-cd2012c60e4149aaaec41582131a5a472025-02-02T18:00:24ZengBioMed CentralGenomics & Informatics1598-866X2234-07422016-03-01141121910.5808/GI.2016.14.1.12164Neuropeptidomics: Mass Spectrometry-Based Identification and Quantitation of NeuropeptidesJi Eun Lee0Center for Theragnosis, Biomedical Research Institute, Korea Institute of Science and Technology, Seoul 02792, Korea.Neuropeptides produced from prohormones by selective action of endopeptidases are vital signaling molecules, playing a critical role in a variety of physiological processes, such as addiction, depression, pain, and circadian rhythms. Neuropeptides bind to post-synaptic receptors and elicit cellular effects like classical neurotransmitters. While each neuropeptide could have its own biological function, mass spectrometry (MS) allows for the identification of the precise molecular forms of each peptide without a priori knowledge of the peptide identity and for the quantitation of neuropeptides in different conditions of the samples. MS-based neuropeptidomics approaches have been applied to various animal models and conditions to characterize and quantify novel neuropeptides, as well as known neuropeptides, advancing our understanding of nervous system function over the past decade. Here, we will present an overview of neuropeptides and MS-based neuropeptidomic strategies for the identification and quantitation of neuropeptides.http://genominfo.org/upload/pdf/gni-14-12.pdfidentificationmass spectrometryneuropeptidespeptidomicsquantitation |
| spellingShingle | Ji Eun Lee Neuropeptidomics: Mass Spectrometry-Based Identification and Quantitation of Neuropeptides Genomics & Informatics identification mass spectrometry neuropeptides peptidomics quantitation |
| title | Neuropeptidomics: Mass Spectrometry-Based Identification and Quantitation of Neuropeptides |
| title_full | Neuropeptidomics: Mass Spectrometry-Based Identification and Quantitation of Neuropeptides |
| title_fullStr | Neuropeptidomics: Mass Spectrometry-Based Identification and Quantitation of Neuropeptides |
| title_full_unstemmed | Neuropeptidomics: Mass Spectrometry-Based Identification and Quantitation of Neuropeptides |
| title_short | Neuropeptidomics: Mass Spectrometry-Based Identification and Quantitation of Neuropeptides |
| title_sort | neuropeptidomics mass spectrometry based identification and quantitation of neuropeptides |
| topic | identification mass spectrometry neuropeptides peptidomics quantitation |
| url | http://genominfo.org/upload/pdf/gni-14-12.pdf |
| work_keys_str_mv | AT jieunlee neuropeptidomicsmassspectrometrybasedidentificationandquantitationofneuropeptides |