NK Cell Subtypes as Regulators of Autoimmune Liver Disease
As major components of innate immunity, NK cells not only exert cell-mediated cytotoxicity to destroy tumors or infected cells, but also act to regulate the functions of other cells in the immune system by secreting cytokines and chemokines. Thus, NK cells provide surveillance in the early defense a...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2016/6903496 |
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| _version_ | 1832556221296541696 |
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| author | Guohui Jiao Bangmao Wang |
| author_facet | Guohui Jiao Bangmao Wang |
| author_sort | Guohui Jiao |
| collection | DOAJ |
| description | As major components of innate immunity, NK cells not only exert cell-mediated cytotoxicity to destroy tumors or infected cells, but also act to regulate the functions of other cells in the immune system by secreting cytokines and chemokines. Thus, NK cells provide surveillance in the early defense against viruses, intracellular bacteria, and cancer cells. However, the effecter function of NK cells must be exquisitely controlled to prevent inadvertent attack against normal “self” cells. In an organ such as the liver, where the distinction between immunotolerance and immune defense against routinely processed pathogens is critical, the plethora of NK cells has a unique role in the maintenance of homeostasis. Once self-tolerance is broken, autoimmune liver disease resulted. NK cells act as a “two-edged weapon” and even play opposite roles with both regulatory and inducer activities in the hepatic environment. That is, NK cells act not only to produce inflammatory cytokines and chemokines, but also to alter the proliferation and activation of associated lymphocytes. However, the precise regulatory mechanisms at work in autoimmune liver diseases remain to be identified. In this review, we focus on recent research with NK cells and their potential role in the development of autoimmune liver disease. |
| format | Article |
| id | doaj-art-cd1e57bfea3d4f24ad2e903958477516 |
| institution | Kabale University |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-cd1e57bfea3d4f24ad2e9039584775162025-02-03T05:46:04ZengWileyGastroenterology Research and Practice1687-61211687-630X2016-01-01201610.1155/2016/69034966903496NK Cell Subtypes as Regulators of Autoimmune Liver DiseaseGuohui Jiao0Bangmao Wang1Department of Gastroenterology, General Hospital, Tianjin Medical University, Tianjin 300052, ChinaDepartment of Gastroenterology, General Hospital, Tianjin Medical University, Tianjin 300052, ChinaAs major components of innate immunity, NK cells not only exert cell-mediated cytotoxicity to destroy tumors or infected cells, but also act to regulate the functions of other cells in the immune system by secreting cytokines and chemokines. Thus, NK cells provide surveillance in the early defense against viruses, intracellular bacteria, and cancer cells. However, the effecter function of NK cells must be exquisitely controlled to prevent inadvertent attack against normal “self” cells. In an organ such as the liver, where the distinction between immunotolerance and immune defense against routinely processed pathogens is critical, the plethora of NK cells has a unique role in the maintenance of homeostasis. Once self-tolerance is broken, autoimmune liver disease resulted. NK cells act as a “two-edged weapon” and even play opposite roles with both regulatory and inducer activities in the hepatic environment. That is, NK cells act not only to produce inflammatory cytokines and chemokines, but also to alter the proliferation and activation of associated lymphocytes. However, the precise regulatory mechanisms at work in autoimmune liver diseases remain to be identified. In this review, we focus on recent research with NK cells and their potential role in the development of autoimmune liver disease.http://dx.doi.org/10.1155/2016/6903496 |
| spellingShingle | Guohui Jiao Bangmao Wang NK Cell Subtypes as Regulators of Autoimmune Liver Disease Gastroenterology Research and Practice |
| title | NK Cell Subtypes as Regulators of Autoimmune Liver Disease |
| title_full | NK Cell Subtypes as Regulators of Autoimmune Liver Disease |
| title_fullStr | NK Cell Subtypes as Regulators of Autoimmune Liver Disease |
| title_full_unstemmed | NK Cell Subtypes as Regulators of Autoimmune Liver Disease |
| title_short | NK Cell Subtypes as Regulators of Autoimmune Liver Disease |
| title_sort | nk cell subtypes as regulators of autoimmune liver disease |
| url | http://dx.doi.org/10.1155/2016/6903496 |
| work_keys_str_mv | AT guohuijiao nkcellsubtypesasregulatorsofautoimmuneliverdisease AT bangmaowang nkcellsubtypesasregulatorsofautoimmuneliverdisease |