Zinc in the Monoaminergic Theory of Depression: Its Relationship to Neural Plasticity
Preclinical and clinical studies have demonstrated that zinc possesses antidepressant properties and that it may augment the therapy with conventional, that is, monoamine-based, antidepressants. In this review we aim to discuss the role of zinc in the pathophysiology and treatment of depression with...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2017/3682752 |
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| _version_ | 1832566993780211712 |
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| author | Urszula Doboszewska Piotr Wlaź Gabriel Nowak Maria Radziwoń-Zaleska Ranji Cui Katarzyna Młyniec |
| author_facet | Urszula Doboszewska Piotr Wlaź Gabriel Nowak Maria Radziwoń-Zaleska Ranji Cui Katarzyna Młyniec |
| author_sort | Urszula Doboszewska |
| collection | DOAJ |
| description | Preclinical and clinical studies have demonstrated that zinc possesses antidepressant properties and that it may augment the therapy with conventional, that is, monoamine-based, antidepressants. In this review we aim to discuss the role of zinc in the pathophysiology and treatment of depression with regard to the monoamine hypothesis of the disease. Particular attention will be paid to the recently described zinc-sensing GPR39 receptor as well as aspects of zinc deficiency. Furthermore, an attempt will be made to give a possible explanation of the mechanisms by which zinc interacts with the monoamine system in the context of depression and neural plasticity. |
| format | Article |
| id | doaj-art-cd128241505e4a4eb300a5b976c3f669 |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-cd128241505e4a4eb300a5b976c3f6692025-02-03T01:02:41ZengWileyNeural Plasticity2090-59041687-54432017-01-01201710.1155/2017/36827523682752Zinc in the Monoaminergic Theory of Depression: Its Relationship to Neural PlasticityUrszula Doboszewska0Piotr Wlaź1Gabriel Nowak2Maria Radziwoń-Zaleska3Ranji Cui4Katarzyna Młyniec5Department of Pharmacobiology, Jagiellonian University Medical College, Medyczna 9, 30-688 Kraków, PolandDepartment of Animal Physiology, Institute of Biology and Biochemistry, Faculty of Biology and Biotechnology, Maria Curie-Sklodowska University, Akademicka 19, 20-033 Lublin, PolandDepartment of Pharmacobiology, Jagiellonian University Medical College, Medyczna 9, 30-688 Kraków, PolandDepartment of Psychiatry, Medical University of Warsaw, Nowowiejska 27, 00-665 Warszawa, PolandJilin Provincial Key Laboratory on Molecular and Chemical Genetics, The Second Hospital of Jilin University, Changchun, Jilin 130041, ChinaDepartment of Pharmacobiology, Jagiellonian University Medical College, Medyczna 9, 30-688 Kraków, PolandPreclinical and clinical studies have demonstrated that zinc possesses antidepressant properties and that it may augment the therapy with conventional, that is, monoamine-based, antidepressants. In this review we aim to discuss the role of zinc in the pathophysiology and treatment of depression with regard to the monoamine hypothesis of the disease. Particular attention will be paid to the recently described zinc-sensing GPR39 receptor as well as aspects of zinc deficiency. Furthermore, an attempt will be made to give a possible explanation of the mechanisms by which zinc interacts with the monoamine system in the context of depression and neural plasticity.http://dx.doi.org/10.1155/2017/3682752 |
| spellingShingle | Urszula Doboszewska Piotr Wlaź Gabriel Nowak Maria Radziwoń-Zaleska Ranji Cui Katarzyna Młyniec Zinc in the Monoaminergic Theory of Depression: Its Relationship to Neural Plasticity Neural Plasticity |
| title | Zinc in the Monoaminergic Theory of Depression: Its Relationship to Neural Plasticity |
| title_full | Zinc in the Monoaminergic Theory of Depression: Its Relationship to Neural Plasticity |
| title_fullStr | Zinc in the Monoaminergic Theory of Depression: Its Relationship to Neural Plasticity |
| title_full_unstemmed | Zinc in the Monoaminergic Theory of Depression: Its Relationship to Neural Plasticity |
| title_short | Zinc in the Monoaminergic Theory of Depression: Its Relationship to Neural Plasticity |
| title_sort | zinc in the monoaminergic theory of depression its relationship to neural plasticity |
| url | http://dx.doi.org/10.1155/2017/3682752 |
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