Prevention and Management of Gastroesophageal Varices in Cirrhosis
Variceal hemorrhage is one of the major complications of liver cirrhosis associated with significant mortality and morbidity. Its management has evolved over the past decade and has substantially reduced the rate of first and recurrent bleeding while decreasing mortality. In general, treatment of es...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | International Journal of Hepatology |
| Online Access: | http://dx.doi.org/10.1155/2012/750150 |
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| _version_ | 1832554456209686528 |
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| author | Yen-I Chen Peter Ghali |
| author_facet | Yen-I Chen Peter Ghali |
| author_sort | Yen-I Chen |
| collection | DOAJ |
| description | Variceal hemorrhage is one of the major complications of liver cirrhosis associated with significant mortality and morbidity. Its management has evolved over the past decade and has substantially reduced the rate of first and recurrent bleeding while decreasing mortality. In general, treatment of esophageal varices can be divided into three categories: primary prophylaxis (prevention of first episode of bleeding), management of acute bleeding, and secondary prophylaxis (prevention of recurrent hemorrhage). The goal of this paper is to describe the current evidence behind the management of esophageal varices. We will discuss indications for primary prophylaxis and the different modes of therapy, pharmacological and interventional treatment in acute bleeding, and therapeutic options in preventing recurrent bleeding. The indications for TIPS will also be reviewed including its possible benefits in acute variceal hemorrhage. |
| format | Article |
| id | doaj-art-cd0999b33aec444285e52650cd0a33f6 |
| institution | Kabale University |
| issn | 2090-3448 2090-3456 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Hepatology |
| spelling | doaj-art-cd0999b33aec444285e52650cd0a33f62025-02-03T05:51:27ZengWileyInternational Journal of Hepatology2090-34482090-34562012-01-01201210.1155/2012/750150750150Prevention and Management of Gastroesophageal Varices in CirrhosisYen-I Chen0Peter Ghali1Division of Hepatology and Gastroenterology, McGill University Health Center, McGill University, Montreal, QC, H3A 1A1, CanadaDivision of Hepatology and Gastroenterology, McGill University Health Center, McGill University, Montreal, QC, H3A 1A1, CanadaVariceal hemorrhage is one of the major complications of liver cirrhosis associated with significant mortality and morbidity. Its management has evolved over the past decade and has substantially reduced the rate of first and recurrent bleeding while decreasing mortality. In general, treatment of esophageal varices can be divided into three categories: primary prophylaxis (prevention of first episode of bleeding), management of acute bleeding, and secondary prophylaxis (prevention of recurrent hemorrhage). The goal of this paper is to describe the current evidence behind the management of esophageal varices. We will discuss indications for primary prophylaxis and the different modes of therapy, pharmacological and interventional treatment in acute bleeding, and therapeutic options in preventing recurrent bleeding. The indications for TIPS will also be reviewed including its possible benefits in acute variceal hemorrhage.http://dx.doi.org/10.1155/2012/750150 |
| spellingShingle | Yen-I Chen Peter Ghali Prevention and Management of Gastroesophageal Varices in Cirrhosis International Journal of Hepatology |
| title | Prevention and Management of Gastroesophageal Varices in Cirrhosis |
| title_full | Prevention and Management of Gastroesophageal Varices in Cirrhosis |
| title_fullStr | Prevention and Management of Gastroesophageal Varices in Cirrhosis |
| title_full_unstemmed | Prevention and Management of Gastroesophageal Varices in Cirrhosis |
| title_short | Prevention and Management of Gastroesophageal Varices in Cirrhosis |
| title_sort | prevention and management of gastroesophageal varices in cirrhosis |
| url | http://dx.doi.org/10.1155/2012/750150 |
| work_keys_str_mv | AT yenichen preventionandmanagementofgastroesophagealvaricesincirrhosis AT peterghali preventionandmanagementofgastroesophagealvaricesincirrhosis |