Interkingdom signaling between gastrointestinal hormones and the gut microbiome

The interplay between the gut microbiota and gastrointestinal hormones plays a pivotal role in the health of the host and the development of diseases. As a vital component of the intestinal microecosystem, the gut microbiota influences the synthesis and release of many gastrointestinal hormones thro...

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Main Authors: Xinyu Zhao, Ye Qiu, Lanfan Liang, Xiangsheng Fu
Format: Article
Language:English
Published: Taylor & Francis Group 2025-12-01
Series:Gut Microbes
Subjects:
Online Access:https://www.tandfonline.com/doi/10.1080/19490976.2025.2456592
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author Xinyu Zhao
Ye Qiu
Lanfan Liang
Xiangsheng Fu
author_facet Xinyu Zhao
Ye Qiu
Lanfan Liang
Xiangsheng Fu
author_sort Xinyu Zhao
collection DOAJ
description The interplay between the gut microbiota and gastrointestinal hormones plays a pivotal role in the health of the host and the development of diseases. As a vital component of the intestinal microecosystem, the gut microbiota influences the synthesis and release of many gastrointestinal hormones through mechanisms such as modulating the intestinal environment, producing metabolites, impacting mucosal barriers, generating immune and inflammatory responses, and releasing neurotransmitters. Conversely, gastrointestinal hormones exert feedback regulation on the gut microbiota by modulating the intestinal environment, nutrient absorption and utilization, and the bacterial biological behavior and composition. The distributions of the gut microbiota and gastrointestinal hormones are anatomically intertwined, and close interactions between the gut microbiota and gastrointestinal hormones are crucial for maintaining gastrointestinal homeostasis. Interventions leveraging the interplay between the gut microbiota and gastrointestinal hormones have been employed in the clinical management of metabolic diseases and inflammatory bowel diseases, such as bariatric surgery and fecal microbiota transplantation, offering promising targets for the treatment of dysbiosis-related diseases.
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issn 1949-0976
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publishDate 2025-12-01
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series Gut Microbes
spelling doaj-art-ccf4e22b472e4fd388cb30f4ad80c37e2025-01-28T17:28:48ZengTaylor & Francis GroupGut Microbes1949-09761949-09842025-12-0117110.1080/19490976.2025.2456592Interkingdom signaling between gastrointestinal hormones and the gut microbiomeXinyu Zhao0Ye Qiu1Lanfan Liang2Xiangsheng Fu3Department of Gastroenterology, Clinical Medical College and the First Affiliated Hospital of Chengdu Medical College, Chengdu, Sichuan, ChinaDepartment of Gastroenterology, Clinical Medical College and the First Affiliated Hospital of Chengdu Medical College, Chengdu, Sichuan, ChinaDepartment of Gastroenterology, Clinical Medical College and the First Affiliated Hospital of Chengdu Medical College, Chengdu, Sichuan, ChinaDepartment of Gastroenterology, Clinical Medical College and the First Affiliated Hospital of Chengdu Medical College, Chengdu, Sichuan, ChinaThe interplay between the gut microbiota and gastrointestinal hormones plays a pivotal role in the health of the host and the development of diseases. As a vital component of the intestinal microecosystem, the gut microbiota influences the synthesis and release of many gastrointestinal hormones through mechanisms such as modulating the intestinal environment, producing metabolites, impacting mucosal barriers, generating immune and inflammatory responses, and releasing neurotransmitters. Conversely, gastrointestinal hormones exert feedback regulation on the gut microbiota by modulating the intestinal environment, nutrient absorption and utilization, and the bacterial biological behavior and composition. The distributions of the gut microbiota and gastrointestinal hormones are anatomically intertwined, and close interactions between the gut microbiota and gastrointestinal hormones are crucial for maintaining gastrointestinal homeostasis. Interventions leveraging the interplay between the gut microbiota and gastrointestinal hormones have been employed in the clinical management of metabolic diseases and inflammatory bowel diseases, such as bariatric surgery and fecal microbiota transplantation, offering promising targets for the treatment of dysbiosis-related diseases.https://www.tandfonline.com/doi/10.1080/19490976.2025.2456592Gastrointestinal hormonesgut microbiotainterkingdom signalingmetabolic diseasedysbiosis
spellingShingle Xinyu Zhao
Ye Qiu
Lanfan Liang
Xiangsheng Fu
Interkingdom signaling between gastrointestinal hormones and the gut microbiome
Gut Microbes
Gastrointestinal hormones
gut microbiota
interkingdom signaling
metabolic disease
dysbiosis
title Interkingdom signaling between gastrointestinal hormones and the gut microbiome
title_full Interkingdom signaling between gastrointestinal hormones and the gut microbiome
title_fullStr Interkingdom signaling between gastrointestinal hormones and the gut microbiome
title_full_unstemmed Interkingdom signaling between gastrointestinal hormones and the gut microbiome
title_short Interkingdom signaling between gastrointestinal hormones and the gut microbiome
title_sort interkingdom signaling between gastrointestinal hormones and the gut microbiome
topic Gastrointestinal hormones
gut microbiota
interkingdom signaling
metabolic disease
dysbiosis
url https://www.tandfonline.com/doi/10.1080/19490976.2025.2456592
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AT yeqiu interkingdomsignalingbetweengastrointestinalhormonesandthegutmicrobiome
AT lanfanliang interkingdomsignalingbetweengastrointestinalhormonesandthegutmicrobiome
AT xiangshengfu interkingdomsignalingbetweengastrointestinalhormonesandthegutmicrobiome