Interkingdom signaling between gastrointestinal hormones and the gut microbiome
The interplay between the gut microbiota and gastrointestinal hormones plays a pivotal role in the health of the host and the development of diseases. As a vital component of the intestinal microecosystem, the gut microbiota influences the synthesis and release of many gastrointestinal hormones thro...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2025-12-01
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| Series: | Gut Microbes |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/19490976.2025.2456592 |
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| _version_ | 1832583329978777600 |
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| author | Xinyu Zhao Ye Qiu Lanfan Liang Xiangsheng Fu |
| author_facet | Xinyu Zhao Ye Qiu Lanfan Liang Xiangsheng Fu |
| author_sort | Xinyu Zhao |
| collection | DOAJ |
| description | The interplay between the gut microbiota and gastrointestinal hormones plays a pivotal role in the health of the host and the development of diseases. As a vital component of the intestinal microecosystem, the gut microbiota influences the synthesis and release of many gastrointestinal hormones through mechanisms such as modulating the intestinal environment, producing metabolites, impacting mucosal barriers, generating immune and inflammatory responses, and releasing neurotransmitters. Conversely, gastrointestinal hormones exert feedback regulation on the gut microbiota by modulating the intestinal environment, nutrient absorption and utilization, and the bacterial biological behavior and composition. The distributions of the gut microbiota and gastrointestinal hormones are anatomically intertwined, and close interactions between the gut microbiota and gastrointestinal hormones are crucial for maintaining gastrointestinal homeostasis. Interventions leveraging the interplay between the gut microbiota and gastrointestinal hormones have been employed in the clinical management of metabolic diseases and inflammatory bowel diseases, such as bariatric surgery and fecal microbiota transplantation, offering promising targets for the treatment of dysbiosis-related diseases. |
| format | Article |
| id | doaj-art-ccf4e22b472e4fd388cb30f4ad80c37e |
| institution | Kabale University |
| issn | 1949-0976 1949-0984 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Gut Microbes |
| spelling | doaj-art-ccf4e22b472e4fd388cb30f4ad80c37e2025-01-28T17:28:48ZengTaylor & Francis GroupGut Microbes1949-09761949-09842025-12-0117110.1080/19490976.2025.2456592Interkingdom signaling between gastrointestinal hormones and the gut microbiomeXinyu Zhao0Ye Qiu1Lanfan Liang2Xiangsheng Fu3Department of Gastroenterology, Clinical Medical College and the First Affiliated Hospital of Chengdu Medical College, Chengdu, Sichuan, ChinaDepartment of Gastroenterology, Clinical Medical College and the First Affiliated Hospital of Chengdu Medical College, Chengdu, Sichuan, ChinaDepartment of Gastroenterology, Clinical Medical College and the First Affiliated Hospital of Chengdu Medical College, Chengdu, Sichuan, ChinaDepartment of Gastroenterology, Clinical Medical College and the First Affiliated Hospital of Chengdu Medical College, Chengdu, Sichuan, ChinaThe interplay between the gut microbiota and gastrointestinal hormones plays a pivotal role in the health of the host and the development of diseases. As a vital component of the intestinal microecosystem, the gut microbiota influences the synthesis and release of many gastrointestinal hormones through mechanisms such as modulating the intestinal environment, producing metabolites, impacting mucosal barriers, generating immune and inflammatory responses, and releasing neurotransmitters. Conversely, gastrointestinal hormones exert feedback regulation on the gut microbiota by modulating the intestinal environment, nutrient absorption and utilization, and the bacterial biological behavior and composition. The distributions of the gut microbiota and gastrointestinal hormones are anatomically intertwined, and close interactions between the gut microbiota and gastrointestinal hormones are crucial for maintaining gastrointestinal homeostasis. Interventions leveraging the interplay between the gut microbiota and gastrointestinal hormones have been employed in the clinical management of metabolic diseases and inflammatory bowel diseases, such as bariatric surgery and fecal microbiota transplantation, offering promising targets for the treatment of dysbiosis-related diseases.https://www.tandfonline.com/doi/10.1080/19490976.2025.2456592Gastrointestinal hormonesgut microbiotainterkingdom signalingmetabolic diseasedysbiosis |
| spellingShingle | Xinyu Zhao Ye Qiu Lanfan Liang Xiangsheng Fu Interkingdom signaling between gastrointestinal hormones and the gut microbiome Gut Microbes Gastrointestinal hormones gut microbiota interkingdom signaling metabolic disease dysbiosis |
| title | Interkingdom signaling between gastrointestinal hormones and the gut microbiome |
| title_full | Interkingdom signaling between gastrointestinal hormones and the gut microbiome |
| title_fullStr | Interkingdom signaling between gastrointestinal hormones and the gut microbiome |
| title_full_unstemmed | Interkingdom signaling between gastrointestinal hormones and the gut microbiome |
| title_short | Interkingdom signaling between gastrointestinal hormones and the gut microbiome |
| title_sort | interkingdom signaling between gastrointestinal hormones and the gut microbiome |
| topic | Gastrointestinal hormones gut microbiota interkingdom signaling metabolic disease dysbiosis |
| url | https://www.tandfonline.com/doi/10.1080/19490976.2025.2456592 |
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