Echinococcus granulosus sensu lato promotes osteoclast differentiation through DUSP4-MAPK signaling in osseous echinococcosis

Echinococcus granulosus sensu lato promotes osteoclast differentiation through DUSP4-MAPK signaling in osseous echinococcosis

IntroductionOsseous echinococcosis, caused by Echinococcus granulosus infection, is characterized by progressive bone destruction driven by abnormal osteoclast activation. Dual-specificity phosphatase 4 (DUSP4), a key negative regulator of the MAPK pathway, inhibits osteoclast differentiation and bo...

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Bibliographic Details
Main Authors: Haohao Sun, Yaqing Liu, Yiping Huang, Kangjun Xiong, Zhendong Zhang, Weishan Wang, Yi Dai, Jing Li, Qi Li, Sibo Wang, Chenhui Shi
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-03-01
Series:Frontiers in Microbiology
Subjects:
Echinococcus granulosus (E. granulosus)
bone
osteoclast
DUSP4
MAPK
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2025.1558603/full
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