Rapid Diagnosis of Intestinal Parasitic Protozoa, with a Focus on Entamoeba histolytica
Entamoeba histolytica is an invasive intestinal pathogenic parasitic protozoan that causes amebiasis. It must be distinguished from Entamoeba dispar and E. moshkovskii, nonpathogenic commensal parasites of the human gut lumen that are morphologically identical to E. histolytica. Detection of specifi...
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| Format: | Article |
| Language: | English |
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Wiley
2009-01-01
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| Series: | Interdisciplinary Perspectives on Infectious Diseases |
| Online Access: | http://dx.doi.org/10.1155/2009/547090 |
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| author | Anjana Singh Eric Houpt William A. Petri |
| author_facet | Anjana Singh Eric Houpt William A. Petri |
| author_sort | Anjana Singh |
| collection | DOAJ |
| description | Entamoeba histolytica is an invasive intestinal pathogenic parasitic protozoan that causes amebiasis. It must be distinguished from Entamoeba dispar and E. moshkovskii, nonpathogenic commensal parasites of the human gut lumen that are morphologically identical to E. histolytica. Detection of specific E. histolytica antigens in stools is a fast, sensitive technique that should be considered as the method of choice. Stool real-time PCR is a highly sensitive and specific technique but its high cost make it unsuitable for use in endemic areas where there are economic constraints. Serology is an important component of the diagnosis of intestinal and especially extraintestinal amebiasis as it is a sensitive test that complements the detection of the parasite antigens or DNA. Circulating Gal/GalNac lectin antigens can be detected in the serum of patients with untreated amoebic liver abscess. On the horizon are multiplex real-time PCR assays which permit the identification of multiple enteropathogens with high sensitivity and specificity. |
| format | Article |
| id | doaj-art-ccd6b7ab20514805af7ae5344e3763b3 |
| institution | Kabale University |
| issn | 1687-708X 1687-7098 |
| language | English |
| publishDate | 2009-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Interdisciplinary Perspectives on Infectious Diseases |
| spelling | doaj-art-ccd6b7ab20514805af7ae5344e3763b32025-02-03T06:08:36ZengWileyInterdisciplinary Perspectives on Infectious Diseases1687-708X1687-70982009-01-01200910.1155/2009/547090547090Rapid Diagnosis of Intestinal Parasitic Protozoa, with a Focus on Entamoeba histolyticaAnjana Singh0Eric Houpt1William A. Petri2University of Virginia, Charlottesville, P.O. Box 801340, VA 22908-1340, USAUniversity of Virginia, Charlottesville, P.O. Box 801340, VA 22908-1340, USAUniversity of Virginia, Charlottesville, P.O. Box 801340, VA 22908-1340, USAEntamoeba histolytica is an invasive intestinal pathogenic parasitic protozoan that causes amebiasis. It must be distinguished from Entamoeba dispar and E. moshkovskii, nonpathogenic commensal parasites of the human gut lumen that are morphologically identical to E. histolytica. Detection of specific E. histolytica antigens in stools is a fast, sensitive technique that should be considered as the method of choice. Stool real-time PCR is a highly sensitive and specific technique but its high cost make it unsuitable for use in endemic areas where there are economic constraints. Serology is an important component of the diagnosis of intestinal and especially extraintestinal amebiasis as it is a sensitive test that complements the detection of the parasite antigens or DNA. Circulating Gal/GalNac lectin antigens can be detected in the serum of patients with untreated amoebic liver abscess. On the horizon are multiplex real-time PCR assays which permit the identification of multiple enteropathogens with high sensitivity and specificity.http://dx.doi.org/10.1155/2009/547090 |
| spellingShingle | Anjana Singh Eric Houpt William A. Petri Rapid Diagnosis of Intestinal Parasitic Protozoa, with a Focus on Entamoeba histolytica Interdisciplinary Perspectives on Infectious Diseases |
| title | Rapid Diagnosis of Intestinal Parasitic Protozoa, with a Focus on Entamoeba histolytica |
| title_full | Rapid Diagnosis of Intestinal Parasitic Protozoa, with a Focus on Entamoeba histolytica |
| title_fullStr | Rapid Diagnosis of Intestinal Parasitic Protozoa, with a Focus on Entamoeba histolytica |
| title_full_unstemmed | Rapid Diagnosis of Intestinal Parasitic Protozoa, with a Focus on Entamoeba histolytica |
| title_short | Rapid Diagnosis of Intestinal Parasitic Protozoa, with a Focus on Entamoeba histolytica |
| title_sort | rapid diagnosis of intestinal parasitic protozoa with a focus on entamoeba histolytica |
| url | http://dx.doi.org/10.1155/2009/547090 |
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